Reactome | PIAS1 [nucleoplasm]

PIAS1 [nucleoplasm]

Stable Identifier

R-HSA-877307

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 SUMO-protein ligase PIAS1, PIAS1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:G2XKQ0 SUMO5

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External Reference Information

External Reference

UniProt:O75925 PIAS1

Gene Names

PIAS1, DDXBP1

Chain

initiator methionine:1, chain:2-651

Reference Genes

BioGPS Gene:8554 PIAS1

COSMIC (genes):PIAS1 PIAS1

CTD Gene:8554 PIAS1

dbSNP Gene:8554 PIAS1

ENSEMBL:ENSG00000033800 PIAS1

HGNC:2752 PIAS1

KEGG Gene (Homo sapiens):8554 PIAS1

Monarch:8554 PIAS1

NCBI Gene:8554 PIAS1

OMIM:603566 PIAS1

UCSC:O75925 PIAS1

Reference Transcript

Other Identifiers

0002320138

11737768_a_at

16802389

216143_at

217862_at

217863_at

217864_s_at

242278_at

3599330

3599331

3599333

3599341

3599366

3599367

3599370

3599372

3599376

3599384

3599388

3599389

3599390

3599392

3599393

3599395

3599400

3599401

3599402

3599403

3599404

3599405

3599406

3599407

3599408

3599409

3599410

3599411

3599412

36573_at

46559_at

55478_at

58682_at

7984453

8554

A_14_P115397

A_23_P163347

A_23_P163353

A_32_P142195

GE58693

GO:0000003

GO:0000082

GO:0000122

GO:0000278

GO:0001085

GO:0002376

GO:0003674

GO:0003677

GO:0003712

GO:0003714

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006357

GO:0006464

GO:0006950

GO:0007049

GO:0007165

GO:0007259

GO:0007283

GO:0008022

GO:0008134

GO:0008150

GO:0008219

GO:0008270

GO:0008283

GO:0008542

GO:0009056

GO:0009058

GO:0016605

GO:0016607

GO:0016740

GO:0016925

GO:0019789

GO:0019899

GO:0019904

GO:0022607

GO:0030154

GO:0031625

GO:0032436

GO:0033235

GO:0034641

GO:0042127

GO:0043066

GO:0043167

GO:0043226

GO:0045444

GO:0045893

GO:0046872

GO:0048856

GO:0050877

GO:0051152

GO:0060334

GO:0061665

GO:0065003

GO:0065004

Hs.250861.0.A1_3p_at

Hs.306457.0.A1_3p_at

Hs.75251.0.S2_3p_at

Hs.75251.0.S3_3p_at

ILMN_1780598

PH_hs_0004297

PH_hs_0031316

TC15000627.hg

U78524_at

g7706636_3p_a_at

Participant Of

hasMember

hasComponent

p-STAT1 dimer:PIAS:SUMO1 [nucleoplasm]

input

PIAS1 binds p-STAT1 dimer

hasCandidate

PIAS1,3 [nucleoplasm]

Inferred To

PIAS1 [nucleoplasm] (Bos taurus)

PIAS1 [nucleoplasm] (Canis familiaris)

PIAS1 [nucleoplasm] (Gallus gallus)

PIAS1 [nucleoplasm] (Sus scrofa)

pli1 [nucleoplasm] (Schizosaccharomyces pombe)

Pias1 [nucleoplasm] (Mus musculus)

Pias1 [nucleoplasm] (Rattus norvegicus)

Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)

gei-17 [nucleoplasm] (Caenorhabditis elegans)

cyth2 [nucleoplasm] (Xenopus tropicalis)

Homologues of PIAS1 [nucleoplasm] (Danio rerio)

pias1b [nucleoplasm] (Danio rerio)

pisA [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

XP_016878177.1, NP_001307616.1, NP_057250.1

OpenTargets

ENSG00000033800

HPA

ENSG00000033800-PIAS1

GeneCards

O75925

Ensembl

ENSP00000249636, ENSP00000438574, ENST00000545237, ENST00000249636, ENSG00000033800

PRO

O75925

PDB

1V66

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54253 ATX1			0.666	7
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	19
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.609	4
UniProt:Q9UIS9 MBD1	2	MBD1 [nucleoplasm] (R-HSA-417134) SUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331)	0.581	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:P51608 MECP2			0.556	3
UniProt:Q9P1N4 Q9P1N4			0.556	3
UniProt:Q9NUW8 TDP1	1	TDP1 [nucleoplasm] (R-HSA-175593)	0.556	3
UniProt:P01023 A2M	3	A2M [platelet alpha granule lumen] (R-HSA-139834) A2M [cytosol] (R-HSA-200618) A2M [extracellular region] (R-HSA-49291)	0.556	3
UniProt:P35240-4 NF2			0.556	3
UniProt:A0A0S2Z5Q7 A0A0S2Z5Q7			0.556	3
UniProt:O43933 PEX1	1	PEX1 [cytosol] (R-HSA-9033116)	0.556	3
UniProt:P07686 HEXB	10	HEXB R284* [lysosomal lumen] (R-HSA-3700930) HEXB S62L [lysosomal lumen] (R-HSA-3700901) HEXB(122-311) [lysosomal lumen] (R-HSA-1605777) HEXB(315-556) [lysosomal lumen] (R-HSA-1605605) HEXB(122-311) [azurophil granule lumen] (R-HSA-6799125) HEXB(315-556) [azurophil granule lumen] (R-HSA-6799134) HEXB(122-311) [extracellular region] (R-HSA-6806190) HEXB(315-556) [extracellular region] (R-HSA-6806188) HEXB I322Kfs5 [lysosomal lumen] (R-HSA-3700889) HEXB M26Cfs5 [lysosomal lumen] (R-HSA-3700843)	0.556	3
UniProt:Q16143 SNCB	1	SNCB [cytosol] (R-HSA-5660390)	0.556	3
UniProt:P29474 NOS3	7	MyrG-NOS3 [Golgi membrane] (R-HSA-534995) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) MyrG-NOS3 [cytosol] (R-HSA-203687) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) NOS3 [cytosol] (R-HSA-202114)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:P45381 ASPA	1	ASPA [cytosol] (R-HSA-5691513)	0.556	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.556	3
UniProt:P26378-2 P263782			0.556	3
UniProt:O43464 HTRA2			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P41219 PERI			0.556	3
UniProt:P02545-2 LMNA	5	p-S22, S395-LMNA-2 [nucleoplasm] (R-HSA-5229019) LMNA-2 [nuclear envelope] (R-HSA-912378) p-S395-LMNA-2 [nucleoplasm] (R-HSA-5228740) Lamin C [nucleoplasm] (R-HSA-264872) LMNA-2 [cytosol] (R-HSA-2995387)	0.556	3
UniProt:P37840 SNCA	4	SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:Q16595 FXN	6	FXN(42-210) [mitochondrial inner membrane] (R-HSA-1299454) FXN(81-210) [mitochondrial matrix] (R-HSA-1362390) FXN(42-210) [mitochondrial matrix] (R-HSA-1299445) FXN(1-210) [mitochondrial inner membrane] (R-HSA-1299444) FXN(1-41) [mitochondrial matrix] (R-HSA-8986117) FXN(1-210) [mitochondrial intermembrane space] (R-HSA-1299451)	0.556	3
UniProt:Q9UBB4 ATX10			0.556	3
UniProt:P50897 PPT1	1	PPT1 [lysosomal lumen] (R-HSA-5690068)	0.556	3
UniProt:Q6NUL7 Q6NUL7			0.556	3
UniProt:P54577 YARS1	1	YARS [cytosol] (R-HSA-379560)	0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [cytosol] (R-HSA-5625607) ATXN3 [nucleoplasm] (R-HSA-6783285)	0.556	9
UniProt:P05129 PRKCG	1	PRKCG [cytosol] (R-HSA-58204)	0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:O14832 PHYH	4	PHYH(1-338) [cytosol] (R-HSA-9033143) PHYH [peroxisomal matrix] (R-HSA-389574) PHYH(1-338) [peroxisomal matrix] (R-HSA-9033535) PHYH(1-30) [peroxisomal matrix] (R-HSA-9033518)	0.556	3
UniProt:O00628 PEX7	2	PEX7 [cytosol] (R-HSA-9033107) PEX7 [peroxisomal membrane] (R-HSA-9033493)	0.556	3
UniProt:P02545 LMNA	3	LMNA-RAF1 fusion [cytosol] (R-HSA-6802399) LMNA(1-664) [nucleoplasm] (R-HSA-535479) p-LMNA-RAF1 fusion [cytosol] (R-HSA-6802537)	0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q16637 SMN1	2	SMN1 [cytosol] (R-HSA-191839) SMN1 [nucleoplasm] (R-HSA-191892)	0.556	3
UniProt:P28358 HXD10			0.556	3
UniProt:P28799 GRN	2	GRN [extracellular region] (R-HSA-6806217) GRN [azurophil granule lumen] (R-HSA-6799168)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q13216-2 ERCC8			0.556	3
UniProt:Q13485 SMAD4	88	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622) SMAD4 E417* [cytosol] (R-HSA-9675623) SMAD4 Y195* [cytosol] (R-HSA-9678462) SMAD4 E108* [cytosol] (R-HSA-9675640) SMAD4 S343* [cytosol] (R-HSA-9675641) SMAD4 E520* [cytosol] (R-HSA-9675636) SMAD4 G510* [cytosol] (R-HSA-9678452) SMAD4 G358* [cytosol] (R-HSA-9678453) SMAD4 E175* [cytosol] (R-HSA-9675637) SMAD4 E307* [cytosol] (R-HSA-9675639) SMAD4 E53* [cytosol] (R-HSA-9675633) SMAD4 S171* [cytosol] (R-HSA-9675634) SMAD4 G30* [cytosol] (R-HSA-9678450) SMAD4 G168* [cytosol] (R-HSA-9678451) SMAD4 Q366* [cytosol] (R-HSA-9675200) SMAD4 R135* [cytosol] (R-HSA-9675090) SMAD4 L146* [cytosol] (R-HSA-9678509) SMAD4 L440* [cytosol] (R-HSA-9678510) SMAD4 Q183* [cytosol] (R-HSA-9675176) SMAD4 Q289* [cytosol] (R-HSA-9675177) SMAD4 Q248* [cytosol] (R-HSA-9675178) SMAD4 Q249* [cytosol] (R-HSA-9675172) SMAD4 Q256* [cytosol] (R-HSA-9675173) SMAD4 Q239* [cytosol] (R-HSA-9675174) SMAD4 Q245* [cytosol] (R-HSA-9675175) SMAD4 Q224* [cytosol] (R-HSA-9675168) SMAD4 W509* [cytosol] (R-HSA-9678497) SMAD4 Q311* [cytosol] (R-HSA-9675169) SMAD4 W398* [cytosol] (R-HSA-9678498) SMAD4 Q250* [cytosol] (R-HSA-9675170) SMAD4 Q410* [cytosol] (R-HSA-9675196) SMAD4 Q534* [cytosol] (R-HSA-9675197) SMAD4 Q83* [cytosol] (R-HSA-9675199) SMAD4 Q448* [cytosol] (R-HSA-9675192) SMAD4 K428R [cytosol] (R-HSA-3311001) SMAD4 Q455* [cytosol] (R-HSA-9675193) SMAD4 R445* [cytosol] (R-HSA-9675065) SMAD4 Q442* [cytosol] (R-HSA-9675194) SMAD4 Q516* [cytosol] (R-HSA-9675195) SMAD4 C443* [cytosol] (R-HSA-9678523) SMAD4 Q334* [cytosol] (R-HSA-9675191) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 L172* [cytosol] (R-HSA-9678514) SMAD4 K122* [cytosol] (R-HSA-9678515) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 Y430* [cytosol] (R-HSA-9678476) SMAD4 Y260* [cytosol] (R-HSA-9678477) SMAD4 Y95* [cytosol] (R-HSA-9678478) SMAD4 Y322* [cytosol] (R-HSA-9678479) SMAD4 E321* [cytosol] (R-HSA-9675658) SMAD4 Y412* [cytosol] (R-HSA-9678469) SMAD4 R515* [cytosol] (R-HSA-3311012) SMAD4 Y328* [cytosol] (R-HSA-9678470) SMAD4 E33* [cytosol] (R-HSA-9675654) SMAD4 Y513* [cytosol] (R-HSA-9678471) SMAD4 E526* [cytosol] (R-HSA-9675648) SMAD4 S138* [cytosol] (R-HSA-9675649) SMAD4 Y276* [cytosol] (R-HSA-9678466) SMAD4 E205* [cytosol] (R-HSA-9675650) SMAD4 E49* [cytosol] (R-HSA-9675651) SMAD4 W101* [cytosol] (R-HSA-9678492) SMAD4 W268* [cytosol] (R-HSA-9678494) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 W524* [cytosol] (R-HSA-9678491) SMAD4 W302* [cytosol] (R-HSA-9678490) SMAD4 S242* [cytosol] (R-HSA-9675167) SMAD4 Q116* [cytosol] (R-HSA-9675166)	0.553	2
UniProt:O75626 PRDM1	1	PRDM1 [nucleoplasm] (R-HSA-6804199)	0.524	2
UniProt:Q9UKL3 CASP8AP2	2	CASP8AP2 [nucleoplasm] (R-HSA-3927945) SUMO1-K1813-CASP8AP2 [nucleoplasm] (R-HSA-3927850)	0.508	4
UniProt:G2XKQ0 SUMO5			0.488	2
UniProt:P03118 VE2			0.488	2

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