Regulation of IFNG signaling

Stable Identifier
R-HSA-877312
Type
Pathway
Species
Homo sapiens
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At least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of cytokine signaling (SOCS), the Scr-homology 2 (SH2)-containing protein tyrosine phosphatases (SHPs), and the protein inhibitors of activated STATs (PIAS). The induction of these regulators seems to be able to stop further signal transduction by inhibiting various steps in IFNG cascade.

Literature References
PubMed ID Title Journal Year
18031232 PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription

Palvimo, JJ

Biochem Soc Trans 2007
10526574 Negative regulators of cytokine signal transduction

Hilton, DJ

Cell Mol Life Sci 1999
12645661 Suppressors of cytokine signalling: SOCS

Larsen, L, Röpke, C

APMIS 2002
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Orthologous Events
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BioModels Database
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