Reactome | TYK2 [cytosol]

TYK2 [cytosol]

Stable Identifier

R-HSA-877348

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Non-receptor tyrosine-protein kinase TYK2, TYK2_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:O75525

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External Reference Information

External Reference

UniProt:P29597 TYK2

Gene Names

TYK2

Chain

chain:1-1187

Reference Genes

BioGPS Gene:7297 TYK2

COSMIC (genes):TYK2 TYK2

CTD Gene:7297 TYK2

dbSNP Gene:7297 TYK2

ENSEMBL:ENSG00000105397 TYK2

HGNC:12440 TYK2

KEGG Gene (Homo sapiens):7297 TYK2

Monarch:7297 TYK2

NCBI Gene:7297 TYK2

OMIM:176941 TYK2

UCSC:P29597 TYK2

Reference Transcript

Other Identifiers

0001980068

11757379_a_at

16868689

205546_s_at

3850280

3850281

3850282

3850284

3850288

3850290

3850292

3850294

3850295

3850296

3850298

3850300

3850301

3850302

3850304

3850307

3850308

3850309

3850310

3850311

3850313

3850314

3850315

3850316

3850317

3850318

3850319

3850320

3850321

3850325

3850326

3850327

3850328

7297

8033996

993_at

A_23_P153311

GE59795

GO:0000166

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005131

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0006464

GO:0006468

GO:0006950

GO:0007165

GO:0008150

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019221

GO:0031702

GO:0035556

GO:0035722

GO:0038155

GO:0043167

GO:0043226

GO:0060337

GO:0070062

GO:0070106

ILMN_1676955

PH_hs_0004337

TC19001164.hg

X54637_at

g4507748_3p_a_at

Participant Of

hasComponent

input

hasCandidate

JAK1, JAK2, (TYK2) [cytosol]

Other forms of this molecule

p-TYK2 [cytosol]

p-Y-TYK2 [cytosol]

p-Y1054,Y1055-TYK2 [cytosol]

p-Y1054-TYK2 [cytosol]

Inferred To

nasp [cytosol] (Xenopus tropicalis)

tyk2 [cytosol] (Danio rerio)

TYK2 [cytosol] (Bos taurus)

TYK2 [cytosol] (Canis familiaris)

TYK2 [cytosol] (Gallus gallus)

TYK2 [cytosol] (Sus scrofa)

hop [cytosol] (Drosophila melanogaster)

Tyk2 [cytosol] (Mus musculus)

Tyk2 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_011526547.1, NP_003322.3

ZINC - World Drugs

TYK2_HUMAN

OpenTargets

ENSG00000105397

ZINC - FDA approved

TYK2_HUMAN

ZINC - Substances

TYK2_HUMAN

ZINC target

P29597

ZINC - Biogenic

TYK2_HUMAN

PRO

P29597

PDB

4GFO, 3ZON, 6NZH, 4GJ3, 6VNS, 3LXP, 6AAM, 5F1Z, 4PO6, 5WAL, 6NZE, 6NZF, 4GVJ, 6DBM, 6NZR, 3NYX, 6OVA, 5C03, 6VNY, 5C01, 4GIH, 6DBK, 6NZP, 4PY1, 4GJ2, 6NSL, 5F20, 6VNV, 4WOV, 4OLI, 3LXN, 6VNX, 5TKD, 4GII, 6NZQ, 3NZ0

ZINC - Investigational

TYK2_HUMAN

IntEnz

2.7.10.2

GeneCards

P29597

HPA

ENSG00000105397-TYK2

Ensembl

ENST00000264818, ENSP00000431885, ENSP00000264818, ENST00000525621, ENSG00000105397

ZINC - Predictions - Purchasable

TYK2_HUMAN

Orphanet

17260

HMDB Protein

HMDBP01375

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5VWX1 KHDRBS2	2	p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031) KHDRBS2 [nucleoplasm] (R-HSA-8849028)	0.781	7
UniProt:Q13643 FHL3			0.718	6
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) SUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.666	4
UniProt:P17181-1 IFNAR1			0.558	3
UniProt:P61978-2 HNRNPK			0.556	3
UniProt:Q9NQX1-2 PRDM5			0.556	3
UniProt:O75525 KHDRBS3	2	p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035) KHDRSB3 [nucleoplasm] (R-HSA-8849040)	0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:O95994 AGR2			0.556	5
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
IntAct:EBI-22311199 CCSB ORF ID			0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9ULX6 AKP8L			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P06463 VE6			0.524	4
UniProt:P04019 VE6			0.524	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2