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TYK2 [cytosol]
Stable Identifier
R-HSA-877348
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Non-receptor tyrosine-protein kinase TYK2, TYK2_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P06463 VE6
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
NPM1-ALK-dependent TYK2 phosphorylation (Homo sapiens)
TYK2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)
TYK2 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
IL12RB1 binds TYK2 (Homo sapiens)
TYK2 [cytosol] (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
IL10RB binds TYK2 (Homo sapiens)
TYK2 [cytosol] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
IL13RA1 binds TYK2 (Homo sapiens)
TYK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29597 TYK2
Gene Names
TYK2
Chain
chain:1-1187
Reference Genes
BioGPS Gene:7297 TYK2
COSMIC (genes):TYK2 TYK2
CTD Gene:7297 TYK2
dbSNP Gene:7297 TYK2
ENSEMBL:ENSG00000105397 TYK2
ENSEMBL_homo_sapiens_GENE:ENSG00000105397.15 TYK2
HGNC:12440 TYK2
KEGG Gene (Homo sapiens):7297 TYK2
Monarch:7297 TYK2
NCBI Gene:7297 TYK2
OMIM:176941 TYK2
UCSC:P29597 TYK2
Reference Transcript
RefSeq:NM_003331.4 TYK2
RefSeq:XM_011528245.1 TYK2
Other Identifiers
11757379_a_at
16868689
205546_PM_s_at
205546_s_at
3850280
3850281
3850282
3850284
3850288
3850290
3850292
3850294
3850295
3850296
3850298
3850300
3850301
3850302
3850304
3850307
3850308
3850309
3850310
3850311
3850313
3850314
3850315
3850316
3850317
3850318
3850319
3850320
3850321
3850325
3850326
3850327
3850328
7297
8033996
993_at
A_23_P153311
GE59795
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005131
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006468
GO:0006955
GO:0007155
GO:0007259
GO:0009898
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019897
GO:0023052
GO:0030154
GO:0030155
GO:0031702
GO:0032729
GO:0032740
GO:0032819
GO:0035556
GO:0035722
GO:0036211
GO:0038196
GO:0042022
GO:0042102
GO:0043226
GO:0046427
GO:0051142
GO:0051239
GO:0060333
GO:0060337
GO:0060397
GO:0070062
GO:0072536
GO:0098542
GO:0098586
GO:0140096
GO:1900182
GO:2000318
HMNXSV003025674
ILMN_1676955
PH_hs_0004337
TC19001164.hg
X54637_at
g4507748_3p_a_at
Participates
as a component of
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL13RA1:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
as an input of
IL12RB1 binds TYK2 (Homo sapiens)
IL13RA1 binds TYK2 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)
NPM1-ALK-dependent TYK2 phosphorylation (Homo sapiens)
IL10RB binds TYK2 (Homo sapiens)
as a candidate of
JAK1, JAK2, (TYK2) [cytosol] (Homo sapiens)
Other forms of this molecule
p-TYK2 [cytosol]
p-Y-TYK2 [cytosol]
p-Y1054,Y1055-TYK2 [cytosol]
p-Y1054-TYK2 [cytosol]
Inferred To
TYK2 [cytosol]
(Bos taurus)
TYK2 [cytosol]
(Canis familiaris)
TYK2 [cytosol]
(Drosophila melanogaster)
TYK2 [cytosol]
(Gallus gallus)
TYK2 [cytosol]
(Mus musculus)
TYK2 [cytosol]
(Rattus norvegicus)
TYK2 [cytosol]
(Sus scrofa)
TYK2 [cytosol]
(Xenopus tropicalis)
Ghost homologue of TYK2 [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_003322.3
,
XP_011526547.1
ZINC - World Drugs
TYK2_HUMAN
Guide to Pharmacology - Targets
2269
OpenTargets
ENSG00000105397
ZINC - FDA approved
TYK2_HUMAN
ZINC - Substances
TYK2_HUMAN
ZINC - Biogenic
TYK2_HUMAN
ZINC target
P29597
PRO
P29597
PDB
8TB5
,
4OLI
,
6NZR
,
4WOV
,
4PY1
,
5F20
,
7UYR
,
4PO6
,
6DBK
,
4GFO
,
3ZON
,
6NZE
,
4GJ3
,
3LXP
,
5WAL
,
6NZH
,
3LXN
,
7K7O
,
7UYT
,
7K7Q
,
8S98
,
7AX4
,
7UYU
,
6NZP
,
6NZQ
,
5C01
,
6OVA
,
6NSL
,
6VNX
,
4GIH
,
5C03
,
6VNY
,
5TKD
,
6X8F
,
8TB6
,
6X8G
,
5F1Z
,
8EXN
,
6NZF
,
7UYS
,
6DBM
,
8S99
,
4GJ2
,
3NYX
,
6VNS
,
4GVJ
,
3NZ0
,
6AAM
,
6VNV
,
4GII
,
8EYC
,
8S9A
ZINC - Investigational
TYK2_HUMAN
HPA
ENSG00000105397-TYK2
GeneCards
P29597
Ensembl
ENSP00000431885
,
ENST00000531836
,
ENSG00000105397
,
ENST00000525621
,
ENSP00000436175
Pharos - Targets
P29597
Orphanet
17260
ZINC - Predictions - Purchasable
TYK2_HUMAN
HMDB Protein
HMDBP01375
Interactors (31)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.781
7
UniProt:Q13643 FHL3
0.718
6
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.666
4
UniProt:P52630 STAT2
4
p-Y690-STAT2 [cytosol]
(R-HSA-909683)
STAT2 [cytosol]
(R-HSA-882029)
p-Y690-STAT2 [nucleoplasm]
(R-HSA-909673)
p-Y-STAT2 [cytosol]
(R-HSA-8987235)
0.641
4
UniProt:P17181 IFNAR1
2
IFNAR1 [plasma membrane]
(R-HSA-877334)
p-Y466,Y481-IFNAR1 [plasma membrane]
(R-HSA-909675)
0.564
2
UniProt:P17181-1 IFNAR1
0.558
3
UniProt:Q3LI67 KRTAP6-3
1
KRTAP6-3 [cytosol]
(R-HSA-6810281)
0.556
3
UniProt:Q05BL1 Q05BL1
0.556
3
UniProt:Q9ULX6 AKAP8L
1
AKAP8L [nucleoplasm]
(R-HSA-9821364)
0.556
3
UniProt:P61978-2 HNRNPK
0.556
3
UniProt:Q9NQX1-2 PRDM5
0.556
3
UniProt:Q9BUZ4 TRAF4
0.556
3
UniProt:O95994 AGR2
0.556
5
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:O75525 KHDRBS3
2
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
0.556
3
UniProt:O75496 GMNN
2
GMNN [nucleoplasm]
(R-HSA-113554)
PolyUb-GMNN [nucleoplasm]
(R-HSA-68585)
0.527
2
UniProt:P11912 CD79A
2
p-Y188,Y199-CD79A [plasma membrane]
(R-HSA-983539)
CD79A [plasma membrane]
(R-HSA-197154)
0.527
2
UniProt:P24394 IL4R
2
IL4R [plasma membrane]
(R-HSA-449670)
p-Y-IL4R [plasma membrane]
(R-HSA-6786087)
0.527
2
UniProt:P52799 EFNB2
2
p-Y311,Y316,Y330-EFNB2 [plasma membrane]
(R-HSA-3928387)
EFNB2 [plasma membrane]
(R-HSA-2682330)
0.527
2
UniProt:P55286 CDH8
1
CDH8 [plasma membrane]
(R-HSA-419000)
0.527
2
UniProt:Q8NFN8 GP156
0.527
2
UniProt:O43567 RNF13
0.527
3
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.527
2
UniProt:Q96FV0 LRC46
0.527
2
UniProt:Q8IYS4 DAAF8
0.527
2
UniProt:P06463 VE6
0.524
4
UniProt:P04019 VE6
0.524
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.524
2
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