Reactome | APP(672-713) [extracellular region]

APP(672-713) [extracellular region]

Stable Identifier

R-HSA-879340

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Beta-amyloid protein 42, Amyloid beta A4 protein, APP, A4_HUMAN

Icon

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gi [extracellular region] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Formyl peptide receptors bind formyl peptides and many other ligands (Homo sapiens)
        
        FPR2 binds FPR2 ligands (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05067 APP

Gene Names

APP, A4, AD1

Chain

signal peptide:1-17, chain:18-770, chain:18-687, chain:18-671, chain:18-286, chain:672-770, chain:672-713, chain:672-711, chain:688-770, peptide:688-713, peptide:688-711, chain:691-770, chain:712-770, chain:714-770, chain:721-770, chain:740-770

Reference Genes

BioGPS Gene:351 APP

COSMIC (genes):APP APP

CTD Gene:351 APP

dbSNP Gene:351 APP

ENSEMBL:ENSG00000142192 APP

HGNC:620 APP

KEGG Gene (Homo sapiens):351 APP

Monarch:351 APP

NCBI Gene:351 APP

OMIM:104760 APP

UCSC:P05067 APP

Reference Transcript

Other Identifiers

0001230601

11738008_s_at

11741216_x_at

11742210_a_at

11742211_x_at

11742215_s_at

11746866_a_at

11750384_a_at

11751350_a_at

11752199_a_at

11752200_x_at

11752481_a_at

11762804_x_at

1462

157

16924551

1AAP

1AMB

1AMC

1AML

1BA4

1BA6

1BJB

1BJC

1BRC

1CA0

1HZ3

1IYT

1MWP

1OWT

1QCM

1QWP

1QXC

1QYT

1TAW

1TKN

1UO7

1UO8

1UOA

1UOI

1X11

1Z0Q

1ZE7

1ZE9

1ZJD

200602_at

211277_3p_x_at

211277_x_at

214953_s_at

2BEG

2BOM

2BP4

2FJZ

2FK1

2FK2

2FK3

2FKL

2FMA

2G47

2IPU

2LFM

2LLM

2LMN

2LMO

2LMP

2LMQ

2LNQ

2LOH

2LP1

2LZ3

2LZ4

2M4J

2M9R

2M9S

2MGT

2MJ1

2MPZ

2MVX

2MXU

2NAO

2OTK

2R0W

2WK3

2Y29

2Y2A

2Y3J

2Y3K

2Y3L

351

3927225

3927227

3927228

3927229

3927230

3927233

3927234

3927237

3927241

3927242

3927262

3927264

3927271

3927272

3927273

3927274

3927281

3927282

3927289

3927298

3927300

3927301

3927306

3927307

3927320

3927335

3927336

3927337

3AYU

3BAE

3BKJ

3DXC

3DXD

3DXE

3GCI

3IFL

3IFN

3IFO

3IFP

3JQ5

3JQL

3JTI

3KTM

3L33

3L81

3MOQ

3MXC

3MXY

3NYJ

3NYL

3OVJ

3OW9

3PZZ

3Q2X

3SV1

3U0T

3UMH

3UMI

3UMK

41136_s_at

4HIX

4JFN

4M1C

4MDR

4MVI

4MVK

4MVL

4NGE

4OJF

4ONF

4ONG

4PQD

4PWQ

4XXD

5AEF

5AM8

5AMB

5BUO

5C67

5CSZ

5HOW

5HOX

5HOY

5KK3

5LFY

5LV0

5MY4

5MYO

5MYX

5ONP

5ONQ

5OQV

5TXD

5VOS

5VZY

5W3P

64309_f_at

6CO3

6GFI

6IYC

8069644

A0A0A0MRG2

A0A140VJC8

A_24_P314159

A_33_P3296479

A_33_P3508822

AAA35540

AAA51564

AAA51722

AAA51726

AAA51727

AAA51768

AAA58727

AAA60163

AAB23646

AAB26263

AAB26264

AAB26265

AAB59501

AAB59502

AAC13654

AAC60601

AAH04369

AAH65529

AAQ14327

AAW82435

AB066441

AEE60915

AF282245

AK295621

AK312326

AP001439

AP001440

AP001441

AP001442

AP001443

APP

APP-201

APP-202

APP-203

APP-204

APP-205

APP-209

AY919674

BAA22264

BAB71958

BAG35248

BAG58500

BC004369

BC065529

CAA30041

CAA30042

CAA30050

CAA31830

CAA68374

CAB000157

CCDS13576

CCDS13577

CCDS33523

CCDS46638

CCDS56212

CCDS56213

CH471079

D87675

E9PG40

EAX09958

EAX09959

EAX09960

EAX09961

EAX09963

EAX09965

ENSG00000142192

ENSP00000284981

ENSP00000345463

ENSP00000346129

ENSP00000350578

ENSP00000351796

ENSP00000387483

ENST00000346798

ENST00000346798.7

ENST00000348990

ENST00000348990.9

ENST00000354192

ENST00000354192.7

ENST00000357903

ENST00000357903.7

ENST00000358918

ENST00000358918.7

ENST00000440126

ENST00000440126.7

EntrezGene:351

EntrezGene:APP

g4502166_3p_at

GE57419

GO:0000003

GO:0000278

GO:0000902

GO:0001774

GO:0001934

GO:0001967

GO:0002265

GO:0002376

GO:0002576

GO:0003674

GO:0003677

GO:0004867

GO:0005102

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005641

GO:0005737

GO:0005768

GO:0005769

GO:0005783

GO:0005788

GO:0005790

GO:0005791

GO:0005794

GO:0005796

GO:0005798

GO:0005829

GO:0005856

GO:0005886

GO:0005887

GO:0005905

GO:0005911

GO:0005929

GO:0005975

GO:0006091

GO:0006378

GO:0006397

GO:0006412

GO:0006417

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006878

GO:0006897

GO:0006915

GO:0006950

GO:0006979

GO:0007049

GO:0007155

GO:0007165

GO:0007176

GO:0007186

GO:0007219

GO:0007267

GO:0007399

GO:0007409

GO:0007568

GO:0007611

GO:0007612

GO:0007617

GO:0007626

GO:0008021

GO:0008088

GO:0008150

GO:0008201

GO:0008203

GO:0008219

GO:0008283

GO:0008285

GO:0008344

GO:0008542

GO:0009056

GO:0009058

GO:0009314

GO:0009986

GO:0009987

GO:0010288

GO:0010466

GO:0010468

GO:0010628

GO:0010629

GO:0010800

GO:0010951

GO:0010952

GO:0010971

GO:0014005

GO:0016020

GO:0016021

GO:0016192

GO:0016199

GO:0016322

GO:0016358

GO:0016504

GO:0019899

GO:0021700

GO:0022607

GO:0030111

GO:0030134

GO:0030154

GO:0030198

GO:0030234

GO:0030414

GO:0030424

GO:0030426

GO:0030546

GO:0030705

GO:0030900

GO:0031093

GO:0031175

GO:0031410

GO:0031594

GO:0031904

GO:0032092

GO:0032588

GO:0032640

GO:0032991

GO:0033138

GO:0034641

GO:0035235

GO:0035253

GO:0040007

GO:0040011

GO:0040014

GO:0042327

GO:0042535

GO:0042592

GO:0042802

GO:0042995

GO:0043005

GO:0043167

GO:0043197

GO:0043198

GO:0043204

GO:0043226

GO:0043235

GO:0043393

GO:0043687

GO:0044267

GO:0044281

GO:0044304

GO:0045080

GO:0045087

GO:0045121

GO:0045177

GO:0045202

GO:0045410

GO:0045665

GO:0045821

GO:0045931

GO:0045944

GO:0046330

GO:0046872

GO:0046914

GO:0048143

GO:0048169

GO:0048471

GO:0048669

GO:0048786

GO:0048856

GO:0048870

GO:0050725

GO:0050730

GO:0050803

GO:0050808

GO:0050877

GO:0050885

GO:0050890

GO:0051091

GO:0051092

GO:0051124

GO:0051233

GO:0051247

GO:0051402

GO:0051425

GO:0051563

GO:0055037

GO:0055085

GO:0070062

GO:0070374

GO:0070555

GO:0070851

GO:0071280

GO:0071287

GO:0071320

GO:0071874

GO:0090647

GO:0097449

GO:0098815

GO:0150003

GO:1900272

GO:1900273

GO:1901224

GO:1902004

GO:1904646

GO:1905606

GO:1905908

GO:1990000

GO:1990090

GO:1990535

GO:1990761

GO:1990812

GO:2000310

GO:2000406

HGNC:620

HM005315

HPA001462

Hs.177486.2.A1_3p_a_at

ILMN_1653283

ILMN_1678152

ILMN_2404063

ILMN_2404065

IPR002223

IPR008154

IPR008155

IPR011178

IPR011993

IPR013803

IPR015849

IPR019543

IPR019744

IPR019745

IPR020901

IPR024329

IPR028866

IPR036176

IPR036454

IPR036669

IPR036880

IPR037071

M15532

M15533

M16765

M18734

M24546

M24547

M28373

M29269

M29270

M33112

M34862

M34863

M34864

M34865

M34866

M34867

M34868

M34869

M34870

M34871

M34872

M34873

M34874

M34875

M34876

M34877

M34878

M34879

M35675

M37895

M37896

MIM:104300

MIM:104760

MIM:605714

NM_000484

NM_001136016

NM_001136129

NM_001204301

NM_001204302

NM_001204303

NM_201413

NM_201414

NP_000475

NP_001129488

NP_001129601

NP_001191230

NP_001191231

NP_001191232

NP_958816

NP_958817

PF00014

PF02177

PF03494

PF10515

PF12924

PF12925

PH_hs_0010546

PR00203

PR00204

PR00759

S45136

S60317

S60721

S61380

S61383

SM00006

SM00131

TC21000340.hg

TC21000887.hg

UPI000002A2F2

UPI000002A2F6

UPI000002A2F7

UPI000002DB1C

UPI00001BE539

UPI00017A7091

X06981

X06982

X06989

X13466

X13467

X13468

X13469

X13470

X13471

X13472

X13473

X13474

X13475

X13476

X13477

X13478

X13479

X13487

X13488

Y00264

Y00264_at

Participant Of

hasMember

output

APP gene expression

This entity regulates

Positively

Influx of extracellular calcium

Other forms of this molecule

APP(18-770) [trans-Golgi network membrane]

APP-C99 [cytosol]

APP(18-687) [extracellular region]

APP(688-770) [plasma membrane]

APP(18-770) [Golgi lumen]

APP(18-770) [plasma membrane]

APP(18-671) [endosome lumen]

APP(714-770) [endosome lumen]

APP(712-770) [endosome lumen]

APP(672-770) [endosome lumen]

APP(672-713) [endosome lumen]

APP(672-711) [endosome lumen]

APP(18-770) [endosome lumen]

APP(18-770) [extracellular region]

APP(18-770) [platelet alpha granule lumen]

APP(672-711) [cytosol]

APP(672-711) [extracellular region]

p-APP [endoplasmic reticulum lumen]

APP [endoplasmic reticulum lumen]

Inferred To

APP(672-713) [extracellular region] (Caenorhabditis elegans)

APP(672-713) [extracellular region] (Danio rerio)

APP(672-713) [extracellular region] (Drosophila melanogaster)

APP(672-713) [extracellular region] (Gallus gallus)

APP(672-713) [extracellular region] (Mus musculus)

APP(672-713) [extracellular region] (Rattus norvegicus)

APP(672-713) [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_001129602.1, NP_001191231.1, NP_958817.1, NP_001129488.1, NP_001129603.1, NP_001129601.1, NP_001191232.1, NP_001191230.1, NP_958816.1, NP_000475.1

OpenTargets

ENSG00000142192

ZINC - Substances

A4_HUMAN

GeneCards

P05067

ZINC target

P05067

ZINC - Biogenic

A4_HUMAN

PRO

P05067

Orphanet

15941

ZINC - Predictions - Purchasable

A4_HUMAN

HMDB Protein

HMDBP01991

PDB

1BA4, 2M4J, 2Y3J, 4MVL, 2BP4, 1ZJD, 3GCI, 3IFP, 2LMN, 5AMB, 3Q2X, 2Y3K, 2FJZ, 4PWQ, 4HIX, 2LMO, 1AAP, 2NAO, 6OC9, 3L81, 3BKJ, 2MPZ, 6GFI, 5KK3, 2OTK, 1UO7, 1MWP, 5VOS, 5MYX, 1HZ3, 2LP1, 3IFO, 2FK2, 4NGE, 5CSZ, 3MXY, 2Y29, 2WK3, 5OQV, 2LNQ, 4XXD, 3MOQ, 1QXC, 1AMC, 1QCM, 5TXD, 3OW9, 1TKN, 1UOI, 2Y2A, 3KTM, 2IPU, 2BOM, 5ONP, 1QYT, 3U0T, 1BRC, 5MYO, 3NYL, 1OWT, 1QWP, 4ONF, 5MY4, 2M9R, 2LZ3, 2M9S, 5C67, 6IYC, 4JFN, 1ZE7, 3DXE, 1TAW, 5LV0, 3AYU, 3JQ5, 5AEF, 5HOY, 4MVK, 2FMA, 2Y3L, 2BEG, 2LMP, 1BJC, 6RHY, 2R0W, 2FKL, 3IFL, 3MXC, 2MXU, 3UMI, 2LLM, 2MGT, 2LOH, 3UMK, 2MVX, 1IYT, 4M1C, 2FK1, 3IFN, 3JTI, 1CA0, 4MVI, 2MJ1, 3L33, 5AM8, 3OVJ, 5W3P, 1AML, 2FK3, 2G47, 3SV1, 5HOX, 6CO3, 3BAE, 3NYJ, 5ONQ, 4MDR, 3UMH, 4PQD, 1BJB, 2LFM, 1UOA, 5BUO, 4ONG, 3PZZ, 1UO8, 3JQL, 2LMQ, 4OJF, 3DXC, 1AMB, 5HOW, 3DXD, 5VZY, 1ZE9, 1Z0Q, 2LZ4, 5LFY, 1BA6, 1X11

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-713) [extracellular region] (R-HSA-879340)	0.993	106
UniProt:O00213 APBB1	1	APBB1 [nucleoplasm] (R-HSA-5683987)	0.839	7
UniProt:P56817 BACE1	8	7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1 [endosome membrane] (R-HSA-5692942)	0.797	8
UniProt:Q9UQF2 JIP1			0.72	5
UniProt:P61812 TGFB2	3	TGFB2 [extracellular region] (R-HSA-114706) TGFB2 [platelet alpha granule lumen] (R-HSA-65938) TGFB2(20-302) [extracellular region] (R-HSA-2395269)	0.718	7
UniProt:Q02410 APBA1	1	APBA1 [cytosol] (R-HSA-5336459)	0.646	4
UniProt:P01137 TGFB1	6	TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.641	3
UniProt:P04156 PRNP	2	PRNP [plasma membrane] (R-HSA-375060) PRNP [cytosol] (R-HSA-9617597)	0.641	3
UniProt:Q92870 APBB2			0.635	3
UniProt:P49768 PSEN1	6	PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [plasma membrane] (R-HSA-201606) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(299-467) [plasma membrane] (R-HSA-2534245) PSEN1(1-298) [plasma membrane] (R-HSA-2534298)	0.632	6
UniProt:P10636 MAPT	3	MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642) MAPT [cytosol] (R-HSA-201574)	0.632	5
UniProt:Q99714 HSD17B10	1	HSD17B10 [mitochondrial matrix] (R-HSA-70831)	0.625	4
UniProt:P02647 APOA1	11	Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) APOA1(25-266) [secretory granule lumen] (R-HSA-350761) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-266) [plasma membrane] (R-HSA-216742) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1(25-266) [extracellular region] (R-HSA-174720) APOA1(25-267) [early endosome] (R-HSA-2429641)	0.625	5
UniProt:O35431 Apba2	1	Apba2 [cytosol] (R-RNO-6794273)	0.618	5
UniProt:P42704 LRPPRC	1	LRPPRC [mitochondrial matrix] (R-HSA-5336174)	0.612	8
UniProt:Q99767 APBA2	1	APBA2 [cytosol] (R-HSA-6794245)	0.592	2
UniProt:Q9NP59 SLC40A1	7	SLC40A1 N144H [plasma membrane] (R-HSA-5655754) SLC40A1 V162del [plasma membrane] (R-HSA-5655818) SLC40A1 D181V [plasma membrane] (R-HSA-5655786) SLC40A1 G80V [plasma membrane] (R-HSA-5655697) SLC40A1 D157G [plasma membrane] (R-HSA-5655794) SLC40A1 A77D [plasma membrane] (R-HSA-5655698) SLC40A1 [plasma membrane] (R-HSA-442390)	0.589	5
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.589	6
UniProt:O75955 FLOT1	1	FLOT1 [plasma membrane] (R-HSA-112174)	0.581	5
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.581	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.564	2
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.564	2
UniProt:P27797 CALR	6	CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905)	0.564	2
UniProt:P08138 NGFR	7	NGFR(29-250) [extracellular region] (R-HSA-194470) NGFR(273-427) [nucleoplasm] (R-HSA-197473) NGFR(251-427) [endosome] (R-HSA-209541) NGFR(251-272) [plasma membrane] (R-HSA-194509) NGFR(251-427) [plasma membrane] (R-HSA-194476) NGFR(273-427) [cytosol] (R-HSA-194458) NGFR [plasma membrane] (R-HSA-193664)	0.558	2
UniProt:O95704 APBB3			0.553	2
UniProt:O60293 ZC3H1			0.547	2
UniProt:Q306T3 Q306T3			0.544	3
UniProt:P15253 CALR			0.544	3
UniProt:P46933	1	APBB1 [nucleoplasm] (R-RNO-5683987)	0.528	2
UniProt:P61457 PCBD1	1	PCBD1 [cytosol] (R-HSA-71131)	0.524	2
UniProt:P01100 FOS	2	p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283) FOS [nucleoplasm] (R-HSA-450216)	0.524	3
UniProt:Q9CR16	1	PPID [nucleoplasm] (R-MMU-8939168)	0.508	3
UniProt:P21359 NF1	37	NF1 F1464L [cytosol] (R-HSA-6802410) NF1 R816* [cytosol] (R-HSA-6802424) NF1 K1444E [cytosol] (R-HSA-6802414) NF1 L1187I [cytosol] (R-HSA-6802417) NF1 R1276P [cytosol] (R-HSA-6802420) NF1 R1412S [cytosol] (R-HSA-6802421) NF1 R2517* [cytosol] (R-HSA-9647532) NF1 Q616G fs4 [cytosol] (R-HSA-9647468) NF1 R2450 [cytosol] (R-HSA-9647535) NF1 R2637* [cytosol] (R-HSA-9647529) NF1 R2637Q [cytosol] (R-HSA-9647525) NF1 R304* [cytosol] (R-HSA-9647522) NF1 R1276* [cytosol] (R-HSA-9647550) NF1 C845V fs33 [cytosol] (R-HSA-9647486) NF1 A132L fs33 [cytosol] (R-HSA-9647480) NF1 R1276Q [cytosol] (R-HSA-9647545) NF1 R1276L [cytosol] (R-HSA-9647547) NF1 C324* [cytosol] (R-HSA-9647483) NF1 A131G fs18 [cytosol] (R-HSA-9647476) NF1 R1534 [cytosol] (R-HSA-9647542) NF1 R1241* [cytosol] (R-HSA-9647473) NF1 R1534Q [cytosol] (R-HSA-9647539) NF1 S1053* [cytosol] (R-HSA-9647502) NF1 E163D fs2 [cytosol] (R-HSA-9656584) NF1(2-2839) [cytosol] (R-HSA-947770) ub-NF1(2-2839) [cytosol] (R-HSA-5658418) NF1 R69N fs7 [cytosol] (R-HSA-9647505) NF1 R440* [cytosol] (R-HSA-9647511) NF1 R440Q [cytosol] (R-HSA-9647508) NF1 G849E fs29 [cytosol] (R-HSA-9656596) NF1 R416Q [cytosol] (R-HSA-9647513) NF1 R304Q [cytosol] (R-HSA-9647519) NF1 R416 [cytosol] (R-HSA-9647516) NF1 E113D fs61 [cytosol] (R-HSA-9647489) NF1 Y489C [cytosol] (R-HSA-9647494) NF1 I1009F fs3 [cytosol] (R-HSA-9647492) NF1 S980* [cytosol] (R-HSA-9647499)	0.508	3
UniProt:P30101 PDIA3	3	PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.499	3
UniProt:P78352 DLG4	3	DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [plasma membrane] (R-HSA-202135) DLG4 [cytosol] (R-HSA-6794267)	0.499	2
UniProt:P56817-1 BACE1			0.489	2
UniProt:O14879 IFIT3	1	IFIT3 [cytosol] (R-HSA-947491)	0.482	2
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.463	2
UniProt:P04578 env	7	Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Surface protein gp120 [viral envelope] (R-HIV-171211) ENV [viral envelope] (R-HIV-173439)	0.462	2
UniProt:Q15392 DHCR24	1	DHCR24 [endoplasmic reticulum membrane] (R-HSA-196414)	0.462	3
UniProt:Q99720 SGMR1			0.462	3