Reactome | APP(672-713) [extracellular region]

APP(672-713) [extracellular region]

Stable Identifier

R-HSA-879340

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Beta-amyloid protein 42, Amyloid beta A4 protein, APP, A4_HUMAN

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Formyl peptide receptors bind formyl peptides and many other ligands (Homo sapiens)
        
        FPR2 binds FPR2 ligands (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 ligands [extracellular region] (Homo sapiens)
        
        APP(672-713) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05067 APP

Gene Names

APP, A4, AD1

Chain

signal peptide:1-17, chain:18-770, chain:18-687, chain:18-671, chain:18-286, chain:672-770, chain:672-713, chain:672-711, chain:688-770, peptide:688-713, peptide:688-711, chain:691-770, chain:712-770, chain:714-770, chain:721-770, chain:740-770

Reference Genes

BioGPS Gene:351 APP

COSMIC (genes):APP APP

CTD Gene:351 APP

dbSNP Gene:351 APP

ENSEMBL:ENSG00000142192 APP

HGNC:620 APP

KEGG Gene (Homo sapiens):351 APP

Monarch:351 APP

NCBI Gene:351 APP

OMIM:104760 APP

UCSC:P05067 APP

Reference Transcript

Other Identifiers

0001230601

11738008_s_at

11741216_x_at

11742210_a_at

11742211_x_at

11742215_s_at

11746866_a_at

11750384_a_at

11751350_a_at

11752199_a_at

11752200_x_at

11752481_a_at

11762804_x_at

16924551

200602_at

211277_3p_x_at

211277_x_at

214953_s_at

351

3927225

3927227

3927228

3927229

3927230

3927233

3927234

3927237

3927241

3927242

3927262

3927264

3927271

3927272

3927273

3927274

3927281

3927282

3927289

3927298

3927300

3927301

3927306

3927307

3927320

3927335

3927336

3927337

41136_s_at

64309_f_at

8069644

A_24_P314159

A_33_P3296479

A_33_P3508822

GE57419

GO:0000003

GO:0000278

GO:0000902

GO:0000978

GO:0001774

GO:0001934

GO:0001967

GO:0002265

GO:0002376

GO:0002576

GO:0003674

GO:0003677

GO:0004867

GO:0005102

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005635

GO:0005641

GO:0005737

GO:0005768

GO:0005769

GO:0005783

GO:0005788

GO:0005790

GO:0005791

GO:0005794

GO:0005796

GO:0005798

GO:0005829

GO:0005856

GO:0005886

GO:0005887

GO:0005905

GO:0005911

GO:0005929

GO:0005975

GO:0006091

GO:0006378

GO:0006397

GO:0006412

GO:0006417

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006878

GO:0006892

GO:0006897

GO:0006915

GO:0006950

GO:0006979

GO:0007049

GO:0007155

GO:0007165

GO:0007176

GO:0007186

GO:0007219

GO:0007267

GO:0007399

GO:0007409

GO:0007568

GO:0007611

GO:0007612

GO:0007617

GO:0007626

GO:0008021

GO:0008088

GO:0008150

GO:0008201

GO:0008203

GO:0008219

GO:0008283

GO:0008285

GO:0008344

GO:0008542

GO:0009056

GO:0009058

GO:0009314

GO:0009986

GO:0009987

GO:0010288

GO:0010466

GO:0010468

GO:0010628

GO:0010629

GO:0010800

GO:0010951

GO:0010952

GO:0010971

GO:0014005

GO:0016020

GO:0016021

GO:0016192

GO:0016199

GO:0016322

GO:0016358

GO:0016504

GO:0019899

GO:0021700

GO:0022607

GO:0030111

GO:0030134

GO:0030154

GO:0030198

GO:0030234

GO:0030414

GO:0030424

GO:0030426

GO:0030546

GO:0030705

GO:0030900

GO:0031093

GO:0031175

GO:0031410

GO:0031594

GO:0031904

GO:0032092

GO:0032588

GO:0032722

GO:0032731

GO:0032755

GO:0032760

GO:0032991

GO:0033138

GO:0034330

GO:0034641

GO:0035235

GO:0035253

GO:0035590

GO:0040007

GO:0040011

GO:0040014

GO:0042327

GO:0042592

GO:0042802

GO:0042995

GO:0043005

GO:0043167

GO:0043197

GO:0043198

GO:0043204

GO:0043226

GO:0043235

GO:0043393

GO:0043687

GO:0044267

GO:0044281

GO:0044304

GO:0045048

GO:0045087

GO:0045121

GO:0045177

GO:0045202

GO:0045665

GO:0045821

GO:0045931

GO:0045944

GO:0046330

GO:0046872

GO:0046914

GO:0048143

GO:0048169

GO:0048471

GO:0048669

GO:0048786

GO:0048856

GO:0048870

GO:0050729

GO:0050730

GO:0050803

GO:0050808

GO:0050877

GO:0050885

GO:0050890

GO:0051091

GO:0051092

GO:0051124

GO:0051233

GO:0051247

GO:0051402

GO:0051425

GO:0051563

GO:0055037

GO:0055085

GO:0061024

GO:0070062

GO:0070374

GO:0070555

GO:0070851

GO:0071280

GO:0071287

GO:0071320

GO:0071874

GO:0090647

GO:0097449

GO:0098815

GO:0150003

GO:1900272

GO:1900273

GO:1901224

GO:1904646

GO:1905606

GO:1905908

GO:1990000

GO:1990090

GO:1990535

GO:1990761

GO:1990812

GO:2000310

GO:2000406

HMNXSV003024560

Hs.177486.2.A1_3p_a_at

ILMN_1653283

ILMN_1678152

ILMN_2404063

ILMN_2404065

PH_hs_0010546

TC21000340.hg

TC21000887.hg

Y00264_at

g4502166_3p_at

Participates

as a member of

as an output of

APP gene expression (Homo sapiens)

This entity regulates

Positively

Influx of extracellular calcium (Homo sapiens)

Other forms of this molecule

APP(18-770) [trans-Golgi network membrane]

APP-C99 [cytosol]

APP(18-687) [extracellular region]

APP(688-770) [plasma membrane]

APP(18-770) [Golgi lumen]

APP(18-770) [plasma membrane]

APP(18-671) [endosome lumen]

APP(714-770) [endosome lumen]

APP(712-770) [endosome lumen]

APP(672-770) [endosome lumen]

APP(672-713) [endosome lumen]

APP(672-711) [endosome lumen]

APP(18-770) [endosome lumen]

APP(18-770) [extracellular region]

APP(18-770) [platelet alpha granule lumen]

p-APP [endoplasmic reticulum lumen]

APP [endoplasmic reticulum lumen]

APP(672-711) [extracellular region]

APP(672-711) [cytosol]

Inferred To

App [extracellular region] (Mus musculus)

App [extracellular region] (Rattus norvegicus)

APP(672-713) [extracellular region] (Sus scrofa)

Appl [extracellular region] (Drosophila melanogaster)

app [extracellular region] (Xenopus tropicalis)

appb [extracellular region] (Danio rerio)

apl-1 [extracellular region] (Caenorhabditis elegans)

APP [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_001191230.1, NP_001191232.1, NP_001129488.1, NP_958817.1, NP_001129601.1, NP_001129603.1, NP_000475.1, NP_001129602.1, NP_001191231.1, NP_958816.1

OpenTargets

ENSG00000142192

ZINC - Substances

A4_HUMAN

ZINC target

P05067

ZINC - Biogenic

A4_HUMAN

PRO

P05067

GlyGen

P05067

PDB

2FK2, 1AMB, 1QWP, 6YHP, 6TI5, 4M1C, 2FK3, 5LFY, 2M9S, 1BJB, 6TI6, 2LMQ, 3UMI, 3PZZ, 5OQV, 3U0T, 6YHX, 3UMH, 3MXC, 3BKJ, 6SZF, 6YHF, 2LMO, 2OTK, 5BUO, 5ONQ, 2Y3K, 6OC9, 3OVJ, 6W0O, 2Y3J, 2NAO, 1BJC, 3GCI, 1QXC, 4MVI, 4NGE, 2M4J, 2LMN, 1UO7, 3MXY, 2FJZ, 1QCM, 2LZ4, 6IYC, 2BOM, 5AM8, 5HOX, 2LOH, 1UOA, 4PWQ, 5LV0, 4HIX, 3L81, 2MPZ, 2FMA, 5MYO, 4PQD, 7JXN, 4MDR, 3SV1, 5VOS, 7JXO, 6CO3, 2LMP, 2IPU, 3KTM, 1TKN, 3IFP, 1X11, 1QYT, 6GFI, 6ITU, 2G47, 6SHS, 5AEF, 3DXD, 6NB9, 1Z0Q, 3IFO, 5HOW, 1ZE9, 2LZ3, 5MY4, 2MJ1, 5VZY, 3UMK, 1AMC, 3IFL, 3DXC, 2LFM, 7B3K, 5W3P, 3NYL, 6TI7, 2BEG, 2FK1, 1MWP, 2R0W, 5ONP, 3Q2X, 1UO8, 3BAE, 4MVL, 6YHI, 2FKL, 2MXU, 4MVK, 3JQ5, 3JTI, 1HZ3, 1BRC, 6YHO, 5KK3, 6RHY, 1AAP, 5C67, 1AML, 2LNQ, 3L33, 2WK3, 2LP1, 3IFN, 4ONG, 2BP4, 7B3J, 1ZJD, 6OIZ, 5HOY, 2LLM, 4ONF, 1OWT, 2M9R, 4OJF, 3JQL, 6WXM, 2MGT, 1CA0, 1UOI, 1TAW, 3OW9, 2Y3L, 3NYJ, 5TXD, 1BA6, 2Y2A, 6O4J, 2MVX, 3MOQ, 3DXE, 5CSZ, 3AYU, 2Y29, 5MYX, 1ZE7, 4XXD, 5AMB, 1BA4, 1IYT, 4JFN

GeneCards

P05067

HPA

ENSG00000142192-APP

Ensembl

ENST00000354192, ENSP00000387483, ENST00000440126, ENSP00000284981, ENSP00000346129, ENST00000348990, ENST00000357903, ENSG00000142192, ENSP00000350578, ENSP00000351796, ENST00000346798, ENST00000358918, ENSP00000345463

Pharos - Targets

P05067

Orphanet

15941

ZINC - Predictions - Purchasable

A4_HUMAN

HMDB Protein

HMDBP01991

Interactors (389)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-711) [extracellular region] (R-HSA-976740) APP-C99 [cytosol] (R-HSA-9617603) APP(672-711) [cytosol] (R-HSA-877188) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(688-770) [plasma membrane] (R-HSA-9010028) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-687) [extracellular region] (R-HSA-9010033) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(672-713) [extracellular region] (R-HSA-879340)	0.993	107
UniProt:P56817 BACE1	8	BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1 [endosome membrane] (R-HSA-5692942) 7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069)	0.865	11
UniProt:O00213 APBB1	1	APBB1 [nucleoplasm] (R-HSA-5683987)	0.839	7
UniProt:P04156 PRNP	2	PRNP [cytosol] (R-HSA-9617597) PRNP [plasma membrane] (R-HSA-375060)	0.775	6
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628)	0.749	8
UniProt:Q99714 HSD17B10	1	HSD17B10 [mitochondrial matrix] (R-HSA-70831)	0.747	7
UniProt:P02647 APOA1	11	APOA1(25-266) [secretory granule lumen] (R-HSA-350761) APOA1(25-266) [extracellular region] (R-HSA-174720) APOA1(19-266) [extracellular region] (R-HSA-264771) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) APOA1(25-266) [plasma membrane] (R-HSA-216742)	0.747	8
UniProt:O95704 APBB3			0.742	5
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [endoplasmic reticulum lumen] (R-HSA-195905)	0.737	5
UniProt:Q9UQF2 JIP1			0.72	5
UniProt:P61812 TGFB2	3	TGFB2(20-302) [extracellular region] (R-HSA-2395269) TGFB2 [extracellular region] (R-HSA-114706) TGFB2 [platelet alpha granule lumen] (R-HSA-65938)	0.705	7
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.703	5
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028) PDIA3 [recycling endosome membrane] (R-HSA-8863849)	0.703	6
UniProt:Q92673 SORL1	2	SORL1 [Golgi membrane] (R-HSA-8871510) SORL1 [endosome membrane] (R-HSA-8871475)	0.69	5
UniProt:Q92876 KLK6			0.683	4
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.675	5
UniProt:Q92529 SHC3	2	SHC3 [cytosol] (R-HSA-3006448) p-Y-SHC3 [cytosol] (R-HSA-3009043)	0.675	5
UniProt:Q9Y287 ITM2B	1	ITM2B(244-266) [extracellular region] (R-HSA-976878)	0.675	4
UniProt:P49810 PSEN2	2	PSEN2(1-297) [plasma membrane] (R-HSA-201599) PSEN2(298-448) [plasma membrane] (R-HSA-9013329)	0.675	4
UniProt:P02511 CRYAB	1	CRYAB [nucleoplasm] (R-HSA-6806336)	0.666	7
UniProt:P11142 HSPA8	10	HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [cytosol] (R-HSA-264476)	0.666	8
UniProt:P61764 STXBP1	2	STXBP1 [plasma membrane] (R-HSA-2980862) STXBP1 [cytosol] (R-HSA-6794256)	0.666	7
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [nucleoplasm] (R-HSA-5082401)	0.666	5
UniProt:P18669 PGAM1	4	PGAM1 [extracellular region] (R-HSA-6806482) PGAM1 [secretory granule lumen] (R-HSA-6803293) PGAM1 [ficolin-1-rich granule lumen] (R-HSA-6803309) PGAM1 [cytosol] (R-HSA-71442)	0.666	4
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370)	0.666	5
UniProt:P62937 PPIA	5	PPIA [extracellular exosome] (R-HSA-6801538) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [extracellular region] (R-HSA-173646) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [cytosol] (R-HSA-173123)	0.666	4
UniProt:P60709 ACTB	5	ACTB(1-375) [plasma membrane] (R-HSA-196016) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [cytosol] (R-HSA-201861)	0.666	8
UniProt:P37840 SNCA	4	SNCA [cytosol] (R-HSA-5658500) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) Ub-SNCA [cytosol] (R-HSA-5660754)	0.659	6
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [specific granule membrane] (R-HSA-6799566) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [tertiary granule membrane] (R-HSA-6800992) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768)	0.659	7
UniProt:P42574 CASP3	5	CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.659	4
UniProt:P36544 CHRNA7	1	CHRNA7 [plasma membrane] (R-HSA-507830)	0.646	4
UniProt:Q02410 APBA1	1	APBA1 [cytosol] (R-HSA-5336459)	0.646	4
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.646	4
UniProt:Q92870 APBB2			0.635	3
UniProt:P49768 PSEN1	6	PSEN1(299-467) [plasma membrane] (R-HSA-2534245) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(1-467) [plasma membrane] (R-HSA-201606) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235)	0.632	6
UniProt:O35431 Apba2	1	Apba2 [cytosol] (R-RNO-6794273)	0.618	5
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1(30-390) [Golgi lumen] (R-HSA-114705)	0.604	3
UniProt:Q99767 APBA2	1	APBA2 [cytosol] (R-HSA-6794245)	0.592	2
UniProt:Q9NP59 SLC40A1	7	SLC40A1 D181V [plasma membrane] (R-HSA-5655786) SLC40A1 N144H [plasma membrane] (R-HSA-5655754) SLC40A1 V162del [plasma membrane] (R-HSA-5655818) SLC40A1 A77D [plasma membrane] (R-HSA-5655698) SLC40A1 D157G [plasma membrane] (R-HSA-5655794) SLC40A1 [plasma membrane] (R-HSA-442390) SLC40A1 G80V [plasma membrane] (R-HSA-5655697)	0.589	5
UniProt:P29353 SHC1	5	p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276)	0.589	6
UniProt:P42704 LRPPRC	1	LRPPRC [mitochondrial matrix] (R-HSA-5336174)	0.584	8
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.581	3
UniProt:O75955 FLOT1	1	FLOT1 [plasma membrane] (R-HSA-112174)	0.581	5
UniProt:P08138 NGFR	7	NGFR(251-427) [endosome] (R-HSA-209541) NGFR(273-427) [nucleoplasm] (R-HSA-197473) NGFR(273-427) [cytosol] (R-HSA-194458) NGFR(251-272) [plasma membrane] (R-HSA-194509) NGFR(29-250) [extracellular region] (R-HSA-194470) NGFR [plasma membrane] (R-HSA-193664) NGFR(251-427) [plasma membrane] (R-HSA-194476)	0.558	2
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747)	0.556	3
UniProt:Q16650 TBR1			0.556	3
UniProt:Q02246 CNTN2	1	CNTN2 [plasma membrane] (R-HSA-373618)	0.556	3
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.556	3
UniProt:P68366 TUBA4A	9	Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A [cytosol] (R-HSA-191694) TUBA4A [extracellular region] (R-HSA-350734) AcK-TUBA4A [cytosol] (R-HSA-5618318) TUBA4A folding intermediate [cytosol] (R-HSA-392800)	0.556	3
UniProt:P68363 TUBA1B	9	TUBA1B [axonemal microtubule] (R-HSA-5610434) L-isoglutamyl polyglycyl-TUBA1B [cytosol] (R-HSA-8867436) TUBA1B unfolded [cytosol] (R-HSA-392781) Ac K40 TUBA1B [axonemal microtubule] (R-HSA-5624854) Polyglutamyl-TUBA1B [cytosol] (R-HSA-8867435) TUBA1B folding intermediate [cytosol] (R-HSA-392797) AcK-TUBA1B [cytosol] (R-HSA-5618285) TUBA1B(1-450) [cytosol] (R-HSA-8955581) TUBA1B [cytosol] (R-HSA-191691)	0.556	3
UniProt:Q8IU99 CALHM1	1	CALHM1 [plasma membrane] (R-HSA-2889051)	0.556	3
UniProt:O75888-3 TNFSF13			0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q99719 SEPT5			0.556	3
IntAct:EBI-25936029 EBI11820565			0.556	3
UniProt:Q13393 PLD1	4	PLD1 [specific granule membrane] (R-HSA-6799531) PLD1 [tertiary granule membrane] (R-HSA-6800955) PLD1 [plasma membrane] (R-HSA-2028998) PLD1 [endoplasmic reticulum membrane] (R-HSA-1498795)	0.556	3
UniProt:Q8WW43 APH1B	2	APH1B [endosome membrane] (R-HSA-9010060) APH1B [plasma membrane] (R-HSA-157340)	0.556	3
UniProt:Q6IPE9 Q6IPE9			0.556	3
UniProt:P0DP24 CALM			0.556	3
UniProt:P14735 IDE	4	IDE [peroxisomal matrix] (R-HSA-9033157) IDE [mitochondrial outer membrane] (R-HSA-5696861) PolyUb-IDE [mitochondrial outer membrane] (R-HSA-6783095) IDE [cytosol] (R-HSA-9033133)	0.556	3
UniProt:P43405-2 P434052			0.556	3
UniProt:P02766 TTR	2	TTR [extracellular region] (R-HSA-976883) TTR [azurophil granule lumen] (R-HSA-6799366)	0.556	3
UniProt:Q13148 TADBP			0.556	6
IntAct:EBI-25936019 CCSB			0.556	3
UniProt:P19544-6 WT1			0.556	3
UniProt:Q6ZNA4-2 Q6ZNA42			0.556	3
UniProt:O43236 SEPTIN4			0.556	3
UniProt:O60260-5 PRKN			0.556	5
UniProt:Q96FW1 OTUB1	2	OTUB1 [nucleoplasm] (R-HSA-6783242) OTUB1 [cytosol] (R-HSA-933411)	0.556	3
IntAct:EBI-25880053 IOH23180			0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:P48736 PIK3CG	1	PIK3CG [cytosol] (R-HSA-392286)	0.556	3
UniProt:Q16740 CLPP			0.556	3
IntAct:EBI-25936001 CCSB			0.556	3
UniProt:Q6AZY7-2 Q6AZY72			0.556	3
UniProt:P00491 PNP	4	PNP [cytosol] (R-HSA-61933) PNP [extracellular region] (R-HSA-6806505) PNP [secretory granule lumen] (R-HSA-6803318) PNP [ficolin-1-rich granule lumen] (R-HSA-6803278)	0.556	9
UniProt:Q9UJC3 HOOK1			0.556	3
UniProt:Q9BX74 TM2D1			0.556	3
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.556	3
UniProt:Q13485 SMAD4	20	SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 E330* [cytosol] (R-HSA-9675622) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 G477* [cytosol] (R-HSA-9678447)	0.556	3
UniProt:P16234-2 PDGFRA			0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [cytosol] (R-HSA-5623651) p-T774-PKN1 [nucleoplasm] (R-HSA-5625721) PKN1 [cytosol] (R-HSA-5623613)	0.556	3
UniProt:O14939 PLD2	2	PLD2 [endoplasmic reticulum membrane] (R-HSA-1498791) PLD2 [plasma membrane] (R-HSA-2029075)	0.556	3
UniProt:P11277 SPTB	1	SPTB [cytosol] (R-HSA-391565)	0.556	6
UniProt:Q96S59 RANBP9	1	RANBP9 [cytosol] (R-HSA-374586)	0.556	3
UniProt:Q14790 CASP8	8	CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [cytosol] (R-HSA-76158)	0.556	3
UniProt:Q00266 MAT1A	4	MAT1A H277Afs75 [cytosol] (R-HSA-5603099) MAT1A V348Gfs3 [cytosol] (R-HSA-5603112) MAT1A K181Vfs*5 [cytosol] (R-HSA-5603077) MAT1A [cytosol] (R-HSA-174379)	0.556	3
UniProt:Q06481-5 APLP2			0.556	3
UniProt:P41586-2 ADCYAP1R1			0.556	3
UniProt:P11021 HSPA5	6	HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [extracellular region] (R-HSA-351322)	0.556	3
UniProt:Q9GZS3 WDR61	2	WDR61 [nucleoplasm] (R-HSA-8866696) WDR61 [cytosol] (R-HSA-8931534)	0.556	3
UniProt:Q9BS26 ERP44	2	ERP44 [extracellular region] (R-HSA-6806302) ERP44 [specific granule lumen] (R-HSA-6799567)	0.556	3
IntAct:EBI-25934154 EBI16882364			0.556	3
UniProt:O75116 ROCK2	2	Activated ROCK2 [cytosol] (R-HSA-4687775) ROCK2 [cytosol] (R-HSA-419058)	0.556	6
UniProt:P21333-2 FLNA			0.556	3
UniProt:Q00005 2ABB			0.556	3
UniProt:Q92599-3 SEPTIN8			0.556	3
UniProt:Q9Y5Q9 GTF3C3	1	GTF3C3 [nucleoplasm] (R-HSA-83691)	0.556	3
IntAct:EBI-25857140 ORF			0.556	3
UniProt:Q16828 DUSP6	2	DUSP6 [nucleoplasm] (R-HSA-2871619) DUSP6 [cytosol] (R-HSA-5675343)	0.556	3
UniProt:O14662-5 STX16			0.556	3
UniProt:P60891 PRPS1	1	PRPS1 [cytosol] (R-HSA-73483)	0.556	3
UniProt:Q8WV41 SNX33			0.556	3
UniProt:O00744 WNT10B	9	WNT10B [extracellular region] (R-HSA-517471) WNT10B [endoplasmic reticulum lumen] (R-HSA-3238279) N4GlycoAsn-WNT10B [endoplasmic reticulum lumen] (R-HSA-3238220) N4GlycoAsn-PalmS WNT10B [endocytic vesicle membrane] (R-HSA-3781985) N4GlycoAsn-PalmS WNT10B [extracellular exosome] (R-HSA-3781957) N4GlycoAsn-PalmS WNT10B [extracellular region] (R-HSA-3247775) N4GlycoAsn-PalmS WNT10B [plasma membrane] (R-HSA-3247791) N4GlycoAsn-PalmS WNT10B [Golgi lumen] (R-HSA-3247821) N4GlycoAsn-PalmS WNT10B [endoplasmic reticulum lumen] (R-HSA-3238333)	0.556	3
UniProt:Q8NHT4 Q8NHT4			0.556	3
UniProt:Q9UGJ0-3 Q9UGJ03			0.556	3
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.556	3
UniProt:P01011 SERPINA3	4	SERPINA3 [platelet alpha granule lumen] (R-HSA-8848913) SERPINA3 [secretory granule lumen] (R-HSA-6801018) SERPINA3 [azurophil granule lumen] (R-HSA-6798754) SERPINA3 [extracellular region] (R-HSA-6806173)	0.556	3
UniProt:P01375 TNF	5	TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.556	3
IntAct:EBI-25834291 CCSB			0.556	3
UniProt:P49755 TMED10	5	TMED10 [endoplasmic reticulum membrane] (R-HSA-5689479) TMED10 [Golgi membrane] (R-HSA-6808801) TMED10 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689845) TMED10 [ER to Golgi transport vesicle membrane] (R-HSA-5689843) TMED10 [transport vesicle] (R-HSA-6808802)	0.556	3
UniProt:O43680 TCF21			0.556	3
UniProt:P62837 UBE2D2	4	UBE2D2 [cytosol] (R-HSA-934628) Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153) UBE2D2 [nucleoplasm] (R-HSA-8852067)	0.556	3
UniProt:Q13564 NAE1	1	NAE1 [cytosol] (R-HSA-8951449)	0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.556	3
UniProt:P23142-4 FBLN1			0.556	3
UniProt:P01138 NGF	7	NGF(19-241) [endoplasmic reticulum lumen] (R-HSA-187047) NGF [Golgi lumen] (R-HSA-166515) NGF(19-241) [Golgi lumen] (R-HSA-187036) NGF [cytosol] (R-HSA-190059) NGF [extracellular region] (R-HSA-167034) NGF(1-241) [endoplasmic reticulum lumen] (R-HSA-187026) NGF(19-241) [extracellular region] (R-HSA-187033)	0.556	9
UniProt:Q92870-2 Q928702			0.556	3
UniProt:P41271-2 NBL1			0.556	3
UniProt:P22694-8 PRKACB			0.556	3
UniProt:Q8WTV0 SCARB1			0.556	3
UniProt:Q92993-2 KAT5			0.556	3
UniProt:P17980 PSMC3	5	PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [cytosol] (R-HSA-68774)	0.556	6
UniProt:Q8N895 ZN366			0.556	3
UniProt:P29466-3 CASP1			0.556	3
UniProt:O60749 SNX2	2	SNX2 [cytoplasmic vesicle membrane] (R-HSA-434216) SNX2 [Golgi membrane] (R-HSA-434333)	0.556	3
UniProt:P12036 NFH			0.556	3
UniProt:Q96AX1 VP33A			0.556	3
UniProt:P61204 ARF3	2	ARF3 [cytosol] (R-HSA-6807733) ARF3 [Golgi membrane] (R-HSA-1604608)	0.556	3
UniProt:P04792 HSPB1	3	p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563)	0.556	3
UniProt:Q3B7T1 EDRF1			0.556	3
UniProt:P28062-2 PSMB8			0.556	3
UniProt:P01034 CST3	6	CST3 [ficolin-1-rich granule lumen] (R-HSA-6801383) p-CST3 [endoplasmic reticulum lumen] (R-HSA-8956911) Variant cystatin-C [extracellular region] (R-HSA-976891) CST3 [endoplasmic reticulum lumen] (R-HSA-8956740) CST3 [extracellular region] (R-HSA-6801534) CST3 [tertiary granule lumen] (R-HSA-6801370)	0.556	3
UniProt:P46379-2 BAG6			0.556	5
UniProt:Q15583-2 TGIF1			0.556	3
UniProt:Q13303 KCNAB2	3	KCNAB2 [specific granule membrane] (R-HSA-6799627) KCNAB2 [tertiary granule membrane] (R-HSA-6800890) KCNAB2 [plasma membrane] (R-HSA-1297366)	0.556	3
UniProt:Q8NE08 Q8NE08			0.556	3
UniProt:Q01658 DR1	1	DR1 [nucleoplasm] (R-HSA-3662280)	0.556	3
IntAct:EBI-25911596 CCSB			0.556	3
IntAct:EBI-25939806 RZPDO834E0519D			0.556	3
UniProt:Q8WUB8-2 PHF10			0.556	3
UniProt:P07948 LYN	7	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) p-Y396-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) p-Y397-LYN [cytosol] (R-HSA-8942608)	0.556	3
UniProt:P48454 PPP3CC	1	PPP3CC [cytosol] (R-HSA-61113)	0.556	3
UniProt:P63010-2 AP2B1			0.556	3
IntAct:EBI-25830852 RZPDO839G03145			0.556	3
UniProt:O75604-3 USP2			0.556	3
UniProt:Q13765 NACA			0.556	3
UniProt:Q92915 FGF14	1	FGF14 [cytosol] (R-HSA-5578837)	0.556	3
UniProt:P21917 DRD4	1	DRD4 [plasma membrane] (R-HSA-390809)	0.556	6
UniProt:P18509 ADCYAP1	4	ADCYAP1(82-129) [extracellular region] (R-HSA-420254) ADCYAP1(132-158) [extracellular region] (R-HSA-420144) ADCYAP1(2-742) [Golgi membrane] (R-HSA-187679) ADCYAP1(132-169) [extracellular region] (R-HSA-420282)	0.556	3
UniProt:P17535 JUND	1	JUND [nucleoplasm] (R-HSA-9009924)	0.556	3
UniProt:P11171-2 EPB41			0.556	3
UniProt:Q9P0L2 MARK1			0.556	3
UniProt:P11171-7 EPB41			0.556	3
UniProt:Q9C026 TRIM9	1	TRIM9 [cytosol] (R-HSA-976054)	0.556	3
UniProt:O94851 MICA2			0.556	3
UniProt:P10909 CLU	4	CLU(23-449) [extracellular region] (R-HSA-349732) CLU(23-449) [platelet alpha granule lumen] (R-HSA-349733) CLU(228-449) [extracellular region] (R-HSA-6810626) CLU(23-227) [extracellular region] (R-HSA-6810660)	0.556	3
UniProt:A4FUJ8 A4FUJ8			0.556	3
UniProt:O43852-3 CALU			0.556	3
UniProt:P30519 HMOX2	3	HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391) HMOX2 [plasma membrane] (R-HSA-6799676) HMOX2 [specific granule membrane] (R-HSA-6799628)	0.556	3
UniProt:D3DTS7 D3DTS7			0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:O14656 TOR1A	1	TOR1A [cytosol] (R-HSA-8862858)	0.556	3
UniProt:P07602 PSAP	7	PSAP(60-142) [extracellular region] (R-HSA-351338) PSAP(311-391) [lysosomal membrane] (R-HSA-1605602) PSAP(326-340) [extracellular region] (R-HSA-5336179) PSAP(17-524) [plasma membrane] (R-HSA-6806262) PSAP(60-142) [lysosomal lumen] (R-HSA-351333) PSAP(17-524) [azurophil granule membrane] (R-HSA-6799212) PSAP(?-?) [extracellular region] (R-HSA-5336190)	0.556	3
UniProt:P04216 THY1	2	cleaved GPI-THY1 [extracellular region] (R-HSA-8941025) GPI-THY1 [plasma membrane] (R-HSA-8940792)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q96FE5 LINGO1	1	LINGO1 [plasma membrane] (R-HSA-3006563)	0.556	3
UniProt:Q13867 BLMH	1	BLMH [cytosol] (R-HSA-983095)	0.556	3
UniProt:P43250-2 GRK6			0.556	3
UniProt:O14645 IDLC			0.556	3
IntAct:EBI-25891095 CCSB			0.556	3
UniProt:P51572 BCAP31	6	BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(238-246) [cytosol] (R-HSA-351912) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826)	0.556	3
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.556	3
UniProt:Q14203-5 DCTN1			0.556	5
UniProt:Q9Y5Z0 BACE2			0.556	3
UniProt:O76041 NEBL			0.556	3
UniProt:Q6PK61 Q6PK61			0.556	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.556	3
UniProt:P62328 TMSB4X	2	TMSB4X [extracellular region] (R-HSA-349753) TMSB4X [platelet alpha granule lumen] (R-HSA-349758)	0.556	3
UniProt:P61586 RHOA	6	RHOA [cell junction] (R-HSA-2134503) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [plasma membrane] (R-HSA-194510) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [cytosol] (R-HSA-194866)	0.556	3
UniProt:Q15714-2 TSC22D1			0.556	3
UniProt:Q8TDB4 HUMMR			0.556	3
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249)	0.556	3
UniProt:P13051-2 UNG			0.556	3
UniProt:P27824-2 P278242			0.556	3
UniProt:Q99466 NOTCH4	20	Glc,GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane] (R-HSA-1911431) FRINGE-modified NOTCH4 Extracellular fragment (NECD4) [Golgi membrane] (R-HSA-1911523) NOTCH4(1337-2003) [plasma membrane] (R-HSA-157213) NOTCH4(1432-1466) [plasma membrane] (R-HSA-157635) NEXT4 [plasma membrane] (R-HSA-157641) Pre-NOTCH4 [endoplasmic reticulum membrane] (R-HSA-157121) 12xFucT-8xGlcS-6xFucS-NOTCH4(24-1336) [Golgi membrane] (R-HSA-1983674) PolyUb-p-NICD4 [nucleoplasm] (R-HSA-9604624) p-NICD4 [nucleoplasm] (R-HSA-9604611) NICD4 [cytosol] (R-HSA-157636) 12xFucT-6xFucS-NOTCH4(24-2003) [endoplasmic reticulum membrane] (R-HSA-1467340) 12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region] (R-HSA-1983677) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane] (R-HSA-1911422) FRINGE-modified NOTCH4 Extracellular Fragment (NECD4) [plasma membrane] (R-HSA-1911521) 12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) [endoplasmic reticulum membrane] (R-HSA-1467405) NICD4 [nucleoplasm] (R-HSA-157945) NOTCH4(1337-2003) [Golgi membrane] (R-HSA-157073) p-4S-NICD4 [cytosol] (R-HSA-9604329) 12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) [Golgi membrane] (R-HSA-1472876) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane] (R-HSA-1911507)	0.556	3
UniProt:A0AVL1 A0AVL1			0.556	3
UniProt:Q8TBC4 UBA3	2	UBA3 [cytosol] (R-HSA-947632) G76-NEDD8-C237-UBA3 [cytosol] (R-HSA-8951640)	0.556	3
UniProt:P42773 CDKN2C	1	CDKN2C [cytosol] (R-HSA-182572)	0.556	3
UniProt:Q96L34 MARK4	1	MARK4 [cytosol] (R-HSA-5626653)	0.556	3
UniProt:O94985-2 CLSTN1			0.556	3
UniProt:P20340-2 RAB6A			0.556	3
UniProt:Q08722-3 CD47			0.556	3
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:Q02818 NUCB1	2	p-NUCB1 [endoplasmic reticulum lumen] (R-HSA-8957027) NUCB1 [endoplasmic reticulum lumen] (R-HSA-8956751)	0.556	3
IntAct:EBI-25935974 CCSB			0.556	3
UniProt:P16112 ACAN	20	KS(2),C4S-ACAN(17-375) [extracellular region] (R-HSA-8855840) KS(2),C6S-ACAN(17-360) [extracellular region] (R-HSA-3814811) KS(2),C6S-ACAN(17-375) [extracellular region] (R-HSA-8855863) KS(2),C6S-ACAN(361-2415) [extracellular region] (R-HSA-3814813) KS(2),CSE-ACAN(361-2415) [extracellular region] (R-HSA-3814817) KS(2),CSE-ACAN(17-375) [extracellular region] (R-HSA-8855829) KS(2),C4S-ACAN [extracellular region] (R-HSA-2318645) KS(2),C4S-ACAN(17-360) [extracellular region] (R-HSA-3814825) KS(2),CSE-ACAN(17-360) [extracellular region] (R-HSA-3814818) KS(2),C4S-ACAN(17-392) [extracellular region] (R-HSA-3791268) KS(2),CSE-ACAN(17-392) [extracellular region] (R-HSA-3791335) KS(2),C6S-ACAN(17-392) [extracellular region] (R-HSA-3791282) KS(2),CSE-ACAN(376-2415) [extracellular region] (R-HSA-8855834) KS(2),CSE-ACAN(393-2415) [extracellular region] (R-HSA-3791277) KS(2),C4S-ACAN(361-2415) [extracellular region] (R-HSA-3814812) KS(2),C6S-ACAN(393-2415) [extracellular region] (R-HSA-2533997) KS(2),C4S-ACAN(376-2415) [extracellular region] (R-HSA-8855833) KS(2),C4S-ACAN(393-2415) [extracellular region] (R-HSA-2533989) KS(2),C6S-ACAN(376-2415) [extracellular region] (R-HSA-8855850) KS(2),C6S-ACAN [extracellular region] (R-HSA-2318671)	0.556	3
UniProt:Q16363-3 Q163633			0.556	3
UniProt:P32745 SSTR3	2	SSTR3 [ciliary membrane] (R-HSA-5624095) SSTR3 [plasma membrane] (R-HSA-374732)	0.556	3
UniProt:Q8N0S8 Q8N0S8			0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) SUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:P09958 FURIN	4	FURIN [Golgi lumen] (R-HSA-448351) FURIN [Golgi membrane] (R-HSA-157049) FURIN [plasma membrane] (R-HSA-2159856) FURIN [extracellular region] (R-HSA-1181103)	0.556	3
UniProt:Q6P4J0 Q6P4J0			0.556	3
UniProt:P61278 SST	2	SST(103-116) [extracellular region] (R-HSA-374738) SST(89-116) [extracellular region] (R-HSA-374710)	0.556	3
UniProt:Q9Y272 RASD1			0.556	3
UniProt:Q8N594 MPND			0.556	3
IntAct:EBI-25935964 CCSB			0.556	3
UniProt:P61158 ACTR3	1	ACTR3 [cytosol] (R-HSA-200811)	0.556	3
UniProt:P30533 AMRP			0.556	3
UniProt:P0CG47 UBB	20	UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-182-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-186-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-110-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100)	0.556	3
UniProt:Q9Y2W7 KCNIP3	1	KCNIP3 [plasma membrane] (R-HSA-5577044)	0.556	3
UniProt:Q92624 APBP2			0.556	3
UniProt:P29400-2 COL4A5			0.556	3
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.556	3
UniProt:Q6DN90-2 Q6DN902			0.556	3
UniProt:P25090 FPR2	4	FPR2 [tertiary granule membrane] (R-HSA-6803296) FPR2 [specific granule membrane] (R-HSA-6803319) FPR2 [ficolin-1-rich granule membrane] (R-HSA-6803335) FPR2 [plasma membrane] (R-HSA-416408)	0.556	3
UniProt:Q8IWL8 STH			0.556	3
UniProt:Q9ULX5 RN112			0.556	3
UniProt:P23560-2 BDNF			0.556	3
IntAct:EBI-25935954 CCSB			0.556	3
UniProt:P49841-2 GSK3B			0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:Q16082 HSPB2			0.556	3
UniProt:P28482 MAPK1	18	MAPK1 [azurophil granule lumen] (R-HSA-6799225) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) MAPK1 [extracellular region] (R-HSA-6806250) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) MAPK1 [cytosol] (R-HSA-59282)	0.556	3
UniProt:P09619 PDGFRB	3	PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.556	3
UniProt:Q92997 DVL3	4	ub-DVL3 [cytosol] (R-HSA-4652688) DVL3 [cytosol] (R-HSA-201678) p-DVL3 [cytosol] (R-HSA-201680) pp-DVL3 [cytosol] (R-HSA-3772400)	0.556	3
UniProt:P04049 RAF1	20	p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) RAF1 [cytosol] (R-HSA-167205) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115)	0.556	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:P04181 OAT	1	PXLP-OAT(26-439) [mitochondrial matrix] (R-HSA-70638)	0.556	3
UniProt:Q15084 PDIA6	3	p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530) PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049)	0.556	3
UniProt:P42338 PIK3CB	1	PIK3CB [cytosol] (R-HSA-74788)	0.556	3
UniProt:P06241 FYN	6	MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873)	0.556	3
IntAct:EBI-25935944 CCSB			0.556	3
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.556	3
UniProt:O14494 PLPP1	1	PPAP2A [plasma membrane] (R-HSA-76106)	0.556	3
UniProt:P23443-4 RPS6KB1			0.556	3
UniProt:P02686-2 MBP			0.556	3
UniProt:Q0P5N6 ARL16			0.556	3
UniProt:P05026 ATP1B1	1	ATP1B1 [plasma membrane] (R-HSA-375071)	0.556	3
UniProt:P15086 CPB1	1	CPB1 [extracellular region] (R-HSA-3229247)	0.556	3
UniProt:Q9BTD3 TM121			0.556	3
UniProt:P06493 CDK1	10	p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075)	0.556	3
IntAct:EBI-25935934 CCSB			0.556	3
UniProt:P84022 SMAD3	20	SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 [nucleoplasm] (R-HSA-206150) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 S425F [cytosol] (R-HSA-8944158) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub-SMAD3 [cytosol] (R-HSA-6782830) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 [cytosol] (R-HSA-170855) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 S425C [cytosol] (R-HSA-3308499) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326)	0.556	3
UniProt:Q6ZW49 PAXIP1	1	PAXIP1 [nucleoplasm] (R-HSA-5619395)	0.556	3
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318)	0.556	3
UniProt:P41227 NAA10			0.556	3
UniProt:Q07954-2 LRP1			0.556	3
IntAct:EBI-25853226 CCSB			0.556	3
UniProt:P43405 SYK	7	SYK [plasma membrane] (R-HSA-139844) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268) p-Y-SYK [cytosol] (R-HSA-9705732) p-Y-SYK [plasma membrane] (R-HSA-429432) p-6Y-SYK [cytosol] (R-HSA-1861712) p-6Y-SYK [cytosol] (R-HSA-983586)	0.556	3
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.556	3
UniProt:P17028 ZNF24			0.556	3
UniProt:P41236 IPP2			0.556	3
UniProt:P63000 RAC1	6	RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [plasma membrane] (R-HSA-351141)	0.556	3
UniProt:Q96GM8 TOE1			0.556	3
IntAct:EBI-25935916 CCSB			0.556	3
UniProt:P22612 PRKACG	3	PRKACG [ciliary base] (R-HSA-5610405) PRKACG [cytosol] (R-HSA-57848) PRKACG [nucleoplasm] (R-HSA-111938)	0.556	3
UniProt:P20674 COX5A	1	COX5A [mitochondrial inner membrane] (R-HSA-164308)	0.556	3
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:O15392 BIRC5	3	BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851) ub-BIRC5 [cytosol] (R-HSA-8955933)	0.556	3
UniProt:O00213-2 APBB1			0.556	6
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.556	3
UniProt:Q15036 SNX17			0.556	3
UniProt:Q71U36 TUBA1A	9	TUBA1A unfolded [cytosol] (R-HSA-392767) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) TUBA1A [cytosol] (R-HSA-191689) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A [axonemal microtubule] (R-HSA-5610433)