The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B

Stable Identifier
R-HSA-879377
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The TRTK-12 fragment of the F-actin capping protein alpha subunit binds S100B in a calcium dependent manner. S100B undergoes a conformational change that is required for subsequent binding to effector proteins (Inman et al. 2002). S100B is a ligand for AGER (Hofmann et al. 1999). In addition this interaction between S100B andF-actin capping protein alpha could be important for regulating actin filament extension (Ivenkov et al. 1995).

Literature References
PubMed ID Title Journal Year
12470955 Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12

Inman, KG, Yang, R, Rustandi, RR, Miller, KE, Baldisseri, DM, Weber, DJ

J Mol Biol 2002
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