Reactome | S100B [extracellular region]

S100B [extracellular region]

Stable Identifier

R-HSA-879433

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Protein S100-B, S100B_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q15109 AGER

Expand all

External Reference Information

External Reference

UniProt:P04271 S100B

Gene Names

S100B

Chain

initiator methionine:, chain:2-92

Reference Genes

BioGPS Gene:6285 S100B

COSMIC (genes):S100B S100B

CTD Gene:6285 S100B

dbSNP Gene:6285 S100B

ENSEMBL:ENSG00000160307 S100B

ENSEMBL_homo_sapiens_GENE:ENSG00000160307.10 S100B

HGNC:10500 S100B

KEGG Gene (Homo sapiens):6285 S100B

Monarch:6285 S100B

NCBI Gene:6285 S100B

OMIM:176990 S100B

UCSC:P04271 S100B

Reference Transcript

Other Identifiers

11720608_a_at

11754115_a_at

11754116_x_at

16926754

209686_PM_at

209686_at

235_at

3935487

3935488

3935491

3935492

3935494

6285

8071036

A_23_P143526

A_33_P3264514

GE58395

GO:0001726

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0007155

GO:0007409

GO:0007417

GO:0007611

GO:0007613

GO:0008092

GO:0008270

GO:0008284

GO:0023052

GO:0030154

GO:0042802

GO:0042803

GO:0043025

GO:0043123

GO:0043167

GO:0043226

GO:0043231

GO:0044548

GO:0045666

GO:0046872

GO:0048156

GO:0048168

GO:0048306

GO:0048471

GO:0048856

GO:0050786

GO:0050877

GO:0097490

GO:1990138

GO:1990845

HMNXSV003002166

HMNXSV003056562

M59488_at

PH_hs_0025153

TC21000559.hg

g12804680_3p_at

g12804680_3p_x_at

Participates

as an output of

S100B gene expression is inhibited by ERBB4:TAB2:NCOR1 (Homo sapiens)

as a component of

S100B homodimer [extracellular region] (Homo sapiens)

Inferred To

S100B [extracellular region] (Bos taurus)

S100B [extracellular region] (Gallus gallus)

S100B [extracellular region] (Mus musculus)

S100B [extracellular region] (Rattus norvegicus)

S100B [extracellular region] (Sus scrofa)

s100b [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_006263.1, XP_016883913.1

ZINC - World Drugs

S100B_HUMAN

OpenTargets

ENSG00000160307

ZINC - FDA approved

S100B_HUMAN

ZINC - Substances

S100B_HUMAN

ZINC - Biogenic

S100B_HUMAN

ZINC target

P04271

PRO

P04271

PDB

5CSF, 3CZT, 3D0Y, 5CSN, 5D7F, 3HCM, 2PRU, 3D10, 2H61, 5CSJ, 1UWO, 5CSI, 2M49, 1MQ1, 4XYN

HPA

ENSG00000160307-S100B

GeneCards

P04271

Ensembl

ENSG00000160307, ENSP00000380769, ENSP00000291700, ENST00000291700, ENST00000397648

Pharos - Targets

P04271

ZINC - Predictions - Purchasable

S100B_HUMAN

HMDB Protein

HMDBP07977

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23297 S100A1	1	S100A1 [extracellular region] (R-HSA-6805991)	0.966	25
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.961	25
UniProt:P26447 S10A4			0.831	8
UniProt:P29034 S10A2			0.805	9
UniProt:P25815 S100P	2	S100P [extracellular region] (R-HSA-6804809) S100P [secretory granule lumen] (R-HSA-6804782)	0.782	7
UniProt:Q9NZD8 SPG21			0.781	7
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.719	5
UniProt:P06703 S10A6			0.646	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.623	3
UniProt:O15151 MDM4	5	PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) MDM4 [nucleoplasm] (R-HSA-349430)	0.611	3
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.611	3
UniProt:Q13015 AF1Q			0.589	2
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.558	2
UniProt:P41271-2 NBL1			0.556	3
UniProt:P17612 PRKACA	4	PRKACA [mitochondrial matrix] (R-HSA-9838291) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.556	3
UniProt:Q5T7Y6 Q5T7Y6			0.556	5
UniProt:Q06481-5 APLP2			0.556	3
UniProt:P01023 A2M	2	A2M [extracellular region] (R-HSA-49291) A2M [platelet alpha granule lumen] (R-HSA-139834)	0.556	3
IntAct:EBI-25891165 CCSB			0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q86YQ8-2 Q86YQ82			0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q8WXG8 S100Z			0.556	3
UniProt:Q13867 BLMH	1	BLMH [cytosol] (R-HSA-983095)	0.556	3
UniProt:P21860 ERBB3			0.556	3
UniProt:O14576-2 O145762			0.556	3
IntAct:EBI-25891095 CCSB			0.556	3
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.556	3
UniProt:Q07954-2 LRP1			0.556	3
IntAct:EBI-25853226 CCSB			0.556	3
UniProt:P0DMV8 HSPA1A	4	HSPA1A [nucleoplasm] (R-HSA-6792605) HSPA1A [extracellular region] (R-HSA-6805872) HSPA1A [ficolin-1-rich granule lumen] (R-HSA-6801496) HSPA1A [cytosol] (R-HSA-6792602)	0.556	3
UniProt:Q9UGL9 CRCT1			0.556	3
UniProt:Q92599-3 SEPTIN8			0.556	3
UniProt:P13051-2 UNG			0.556	3
UniProt:P17028 ZNF24			0.556	3
UniProt:O75553-5 DAB1			0.556	3
UniProt:P27824-2 P278242			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [plasma membrane] (R-HSA-432796) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [cytosol] (R-HSA-445368)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:P06702 S100A9	3	S100A9 [secretory granule lumen] (R-HSA-6804774) S100A9 [cytosol] (R-HSA-9626869) S100A9 [extracellular region] (R-HSA-5432857)	0.556	3
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.556	3
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.556	3
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.556	3
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.544	2
UniProt:Q15418 RPS6KA1	7	RPS6KA1 [nucleoplasm] (R-HSA-199860) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.544	2
UniProt:P31949 S100A11	2	S100A11 [extracellular region] (R-HSA-6804808) S100A11 [secretory granule lumen] (R-HSA-6804784)	0.543	5
UniProt:Q92843 B2CL2			0.488	2

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