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CAPZA2 [cytosol]
Stable Identifier
R-HSA-879448
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
F-actin-capping protein subunit alpha-2, CAZA2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
F-actin capping protein binds to the barbed end of elongating F-actin (Homo sapiens)
F-actin capping protein [cytosol] (Homo sapiens)
F-actin capping protein alpha subunit [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
F-actin capping protein:f-actin [cytosol] (Homo sapiens)
F-actin capping protein [cytosol] (Homo sapiens)
F-actin capping protein alpha subunit [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
F-actin capping protein is a heterodimer (Homo sapiens)
F-actin capping protein [cytosol] (Homo sapiens)
F-actin capping protein alpha subunit [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
F-actin capping protein alpha subunit [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
LRRC16A binds F-actin capping protein (Homo sapiens)
F-actin capping protein [cytosol] (Homo sapiens)
F-actin capping protein alpha subunit [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
LRRC16A:F-actin capping protein [cytosol] (Homo sapiens)
F-actin capping protein [cytosol] (Homo sapiens)
F-actin capping protein alpha subunit [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
Kinesins:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (IHC) [plasma membrane] (Homo sapiens)
Inner hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Inner hair cell stereocilium tip [cytosol] (Homo sapiens)
F-actin capping protein [cytosol] (Homo sapiens)
F-actin capping protein alpha subunit [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-independent Golgi-to-ER retrograde traffic (Homo sapiens)
Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Homo sapiens)
Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
CAPZ [cytosol] (Homo sapiens)
CAPZA2:CAPZB [cytosol] (Homo sapiens)
CAPZA2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P47755 CAPZA2
Gene Names
CAPZA2
Chain
initiator methionine:, chain:2-286
Reference Genes
BioGPS Gene:830 CAPZA2
COSMIC (genes):CAPZA2 CAPZA2
CTD Gene:830 CAPZA2
dbSNP Gene:830 CAPZA2
ENSEMBL:ENSG00000198898 CAPZA2
HGNC:1490 CAPZA2
KEGG:hsa:830 CAPZA2
Monarch:830 CAPZA2
NCBI Gene:830 CAPZA2
OMIM:601571 CAPZA2
UCSC:P47755 CAPZA2
Reference Transcript
RefSeq:NM_006136.2 CAPZA2
Other Identifiers
11723011_s_at
11723012_a_at
11723013_x_at
11747046_x_at
11750192_x_at
1569450_3p_at
1569450_PM_at
1569450_at
17050622
201237_PM_at
201237_at
201238_PM_s_at
201238_s_at
3020424
3020425
3020445
3020446
3020447
3020453
3020454
3020458
3020464
3020465
3020466
3020468
3020471
3020473
3020474
3020475
3020476
3020477
3020480
3020481
3020483
3020484
3020485
3020486
3020487
3020488
3020489
3020491
3638241
3638244
36641_at
67828_r_at
73361_at
8135625
830
A_14_P100172
A_14_P108438
A_23_P307940
A_24_P703614
GE58868
GE79906
GE86004
GO:0003779
GO:0005515
GO:0005576
GO:0005829
GO:0005856
GO:0005903
GO:0007010
GO:0008092
GO:0008290
GO:0015629
GO:0016020
GO:0030036
GO:0030479
GO:0030863
GO:0043226
GO:0051015
GO:0051016
GO:0051693
GO:0065003
GO:0070062
HMNXSV003017687
Hs.75546.0.S3_3p_at
Hs2.404630.1.S1_3p_at
Hs2.404630.1.S1_3p_x_at
ILMN_1768870
PH_hs_0028247
U03851_at
g13529130_3p_a_at
Participates
as a member of
F-actin capping protein alpha subunit [cytosol] (Homo sapiens)
as a component of
CAPZA2:CAPZB [cytosol] (Homo sapiens)
Other forms of this molecule
CAPZA2(265-276) [extracellular region]
Inferred To
Capza2 [cytosol]
(Mus musculus)
Capza2 [cytosol]
(Rattus norvegicus)
acpB [cytosol]
(Dictyostelium discoideum)
acp1 [cytosol]
(Schizosaccharomyces pombe)
CAPZA2 [cytosol]
(Bos taurus)
CAPZA2 [cytosol]
(Canis familiaris)
CAPZA2 [cytosol]
(Gallus gallus)
CAPZA2 [cytosol]
(Sus scrofa)
cpa [cytosol]
(Drosophila melanogaster)
cap-1 [cytosol]
(Caenorhabditis elegans)
CAP1 [cytosol]
(Saccharomyces cerevisiae)
CAPZA1 [cytosol]
(Plasmodium falciparum)
capza2 [cytosol]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSP00000354947
,
ENST00000361183
OpenTargets
ENSG00000198898
HPA
ENSG00000198898-CAPZA2
PRO
P47755
Pharos - Targets
P47755
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.725
7
UniProt:Q9Y5K6 CD2AP
1
CD2AP [cytosol]
(R-HSA-373620)
0.643
5
UniProt:P52907 CAPZA1
2
CAPZA1(265-276) [extracellular region]
(R-HSA-879421)
CAPZA1 [cytosol]
(R-HSA-879363)
0.643
5
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
15
UniProt:Q14203 DCTN1
7
DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711969)
DCTN1(1-599)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711960)
DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9701997)
DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711959)
DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711953)
DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711962)
DCTN1 [cytosol]
(R-HSA-535580)
0.615
6
UniProt:Q9JLQ0 Cd2ap
1
CD2AP_MOUSE [cytosol]
(R-MMU-451711)
0.564
2
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.527
4
UniProt:Q14247 CTTN
2
CTTN [cytosol]
(R-HSA-201894)
p-S113-CTTN [cytosol]
(R-HSA-442842)
0.527
2
UniProt:Q96P48 ARAP1
2
ARAP1 [cytosol]
(R-HSA-3211582)
p-Y231-ARAP1 [cytosol]
(R-HSA-8848869)
0.527
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.527
3
UniProt:Q92600 RQCD1
2
RQCD1 [nucleoplasm]
(R-HSA-6810130)
RQCD1 [cytosol]
(R-HSA-430029)
0.527
4
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
5
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