Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
NR3C1 [nucleoplasm]
Stable Identifier
R-HSA-879837
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Glucocorticoid receptor, GCR_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
ATP hydrolysis by HSP90 (Homo sapiens)
HSP90 complexes [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:NR3C1:NR3C1 ligands [nucleoplasm] (Homo sapiens)
NR3C1:NR3C1 ligands [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
SHR:SH [nucleoplasm] (Homo sapiens)
NR3C1:NR3C1 ligands [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:NR3C1:NR3C1 ligands [nucleoplasm] (Homo sapiens)
NR3C1:NR3C1 ligands [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
Circadian Clock (Homo sapiens)
Expression of PERIOD-2 (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
FOXO1 and NR3C1 bind TRIM63 gene promoter (Homo sapiens)
FOXO1:NR3C1:(ALDO,11DCORST,CORST,CORT):TRIM63 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
TRIM63 gene expression is stimulated by FOXO1 and FOXO3 (Homo sapiens)
FOXO1:NR3C1:(ALDO,11DCORST,CORST,CORT):TRIM63 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by NPAS4 (Homo sapiens)
Regulation of NPAS4 gene expression (Homo sapiens)
Regulation of NPAS4 gene transcription (Homo sapiens)
Activated glucocorticoid receptor binds NPAS4 gene promoter (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer:NPAS4 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
Activated glucocorticoid receptor represses NPAS4 gene transcription (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer:NPAS4 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
DEXA:NR3C1 complex binds RUNX2 gene proximal promoter (Homo sapiens)
Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)
Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
SUMOylation of NR3C1 (GR) with SUMO1 (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Expression (Homo sapiens)
EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
HIF1A,EPAS1 promote PTK6 gene expression (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
NR3C1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04150 NR3C1
Gene Names
NR3C1, GRL
Chain
chain:1-777
Reference Genes
COSMIC (genes):NR3C1 NR3C1
dbSNP Gene:2908 NR3C1
ENSEMBL:ENSG00000113580 NR3C1
Participates
as a component of
NR3C1:NR3C1 ligands [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
SUMO1-K277,K293-NR3C1 [nucleoplasm]
NR3C1 [cytosol]
Inferred To
Ghost homologue of NR3C1 [nucleoplasm]
(Plasmodium falciparum)
nr3c1 [nucleoplasm]
(Danio rerio)
nr3c1 [nucleoplasm]
(Xenopus tropicalis)
knrl [nucleoplasm]
(Drosophila melanogaster)
Nr3c1 [nucleoplasm]
(Mus musculus)
Nr3c1 [nucleoplasm]
(Rattus norvegicus)
ERR [nucleoplasm]
(Drosophila melanogaster)
kni [nucleoplasm]
(Drosophila melanogaster)
NR3C1-1 [nucleoplasm]
(Gallus gallus)
NR3C1 [nucleoplasm]
(Bos taurus)
NR3C1 [nucleoplasm]
(Canis familiaris)
NR3C1 [nucleoplasm]
(Sus scrofa)
Homologues of NR3C1-1 [nucleoplasm]
(Drosophila melanogaster)
eg [nucleoplasm]
(Drosophila melanogaster)
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07900 HSP90AA1
8
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
0.775
8
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.643
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.635
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.611
5
UniProt:P31948 STIP1
1
STIP1 [cytosol]
(R-HSA-443857)
0.61
5
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.527
2
UniProt:P25491
3
SOH-C149,C150-DNAJA1 [cytosol]
(R-SCE-9857072)
DNAJA4 [cytosol]
(R-SCE-3371578)
DNAJA2 [cytosol]
(R-SCE-3371555)
0.499
5
UniProt:P06239 LCK
4
LCK [cytosol]
(R-HSA-167609)
p-Y394-LCK [cytosol]
(R-HSA-202308)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
0.463
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text