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Activation of STAT5a/b by JAK2

Stable Identifier
R-HSA-879909
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

JAK2 phosphorylates STAT5; phosphorylated STAT5 dimerizes and translocates to the nucleus (Darnell et al., 1994), binds DNA and activates target genes including c-fos, pim-1, oncostatin M, and Id-1 (Mui et al. 1996). STAT5 activation is believed to be the primary signaling mechanism for Bc (Ihle, 2001).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane]
Physical Entity
Activity
Orthologous Events