Reactome: A Curated Pathway Database

Activation of STAT5a/b by JAK2

Stable Identifier
R-HSA-879909
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

JAK2 phosphorylates STAT5; phosphorylated STAT5 dimerizes and translocates to the nucleus (Darnell et al., 1994), binds DNA and activates target genes including c-fos, pim-1, oncostatin M, and Id-1 (Mui et al. 1996). STAT5 activation is believed to be the primary signaling mechanism for Bc (Ihle, 2001).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] protein tyrosine kinase activity (0004713)
Orthologous Events