Reactome: A Curated Pathway Database

SHC1 bound to the common beta chain becomes tyrosine phosphorylated

Stable Identifier
R-HSA-879925
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

IL-3, IL-5 and GM-CSF all induce tyrosine phosphorylation of Shc (Dorsch et al. 1994). Three sites are known to mediate specific downstream associations; tyrosine Y427 (Salcini et al. 1994) mediates the subsequent association of Shc with Grb2 (Salcini et al. 1994). The identity of the kinase is unknown. Y349 and Y350 phosphorylation is not required for Ras-MAPK signaling but are involved in IL-3-induced cell survival (Gotoh et al. 1996).
Residue numbering used here refers to Uniprot P29353 where the p66 isoform has been selected as the canonical form. Literature references given here refer to the p52 isoform which lacks the first 110 residues, so Y427 is referred to as Y317 in Salcini et al. 1994, Y349 and Y350 as Y239 and Y240 in Gotoh et al. 1996.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of Unkown tyrosine kinase [cytosol] Unkown tyrosine kinase [cytosol] protein tyrosine kinase activity (0004713)