Reactome | IL3RA [plasma membrane]

IL3RA [plasma membrane]

Stable Identifier

R-HSA-879938

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-3 receptor subunit alpha, IL3RA_HUMAN, CD123

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Locations in the PathwayBrowser for interactor UniProt:Q5BJH2-2 TMEM128

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External Reference Information

External Reference

UniProt:P26951 IL3RA

Gene Names

IL3RA, IL3R

Chain

signal peptide:1-18, chain:19-378

Reference Genes

BioGPS Gene:3563 IL3RA

COSMIC (genes):IL3RA IL3RA

CTD Gene:3563 IL3RA

dbSNP Gene:3563 IL3RA

ENSEMBL:ENSG00000185291 IL3RA

HGNC:6012 IL3RA

KEGG:hsa:3563 IL3RA

Monarch:3563 IL3RA

NCBI Gene:3563 IL3RA

OMIM:308385 IL3RA

OMIM:430000 IL3RA

UCSC:P26951 IL3RA

Reference Transcript

Participates

as an input of

Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)

as a component of

IL3:IL3RA [plasma membrane] (Homo sapiens)

Inferred To

Il3ra [plasma membrane] (Rattus norvegicus)

CSF2RA [plasma membrane] (Gallus gallus)

Ghost homologue of IL3RA [plasma membrane] (Canis familiaris)

Ghost homologue of IL3RA [plasma membrane] (Mus musculus)

IL3RA [plasma membrane] (Bos taurus)

Cross References

RefSeq

NP_002174.1, XP_005274837.1, XP_005274488.1, NP_001254642.1

Guide to Pharmacology - Targets

1705

ENSEMBL

ENSG00000292332, ENSP00000370878, ENST00000381469, ENSP00000518590, ENST00000331035, ENSG00000185291, ENST00000711219, ENSP00000327890, ENST00000711217, ENSP00000518612

OpenTargets

ENSG00000185291

HPA

ENSG00000185291-IL3RA

GeneCards

IL3RA

PRO

P26951

Pharos - Targets

P26951

GlyGen

P26951

PDB

6NMY, 5UV8, 4JZJ, 5UWC

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6X1 SERP1	2	SERP1 [endoplasmic reticulum membrane] (R-HSA-381045) SERP1 [cytosol] (R-HSA-5250574)	0.556	3
UniProt:Q8N2H4 SYS1	1	SYS1 [trans-Golgi network membrane] (R-HSA-6813921)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q9NZG7 NINJ2			0.556	3
UniProt:Q8WWP7 GIMA1			0.556	3
UniProt:Q8N6F1-2 CLDN19			0.556	3
UniProt:Q9BVK8 TM147			0.556	3
UniProt:A5PKU2 A5PKU2			0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) p-T497-PRKCA [cytosol] (R-HSA-5218731) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.556	3
UniProt:Q9NXK6 PAQR5			0.556	3
UniProt:P54852 EMP3			0.556	3
UniProt:O14523 C2C2L			0.556	3
UniProt:Q5BJH2-2 TMEM128			0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:Q8TBM7 TM254			0.556	3
UniProt:Q15047-2 SETDB1			0.556	3
UniProt:Q0VAQ4 SMAGP			0.556	3
UniProt:Q6PI78 TMM65			0.556	3
UniProt:O95393 BMP10	2	BMP10(22-424) [extracellular region] (R-HSA-2396409) BMP10 [extracellular region] (R-HSA-8858374)	0.556	3
UniProt:O95183 VAMP5			0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.556	3

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