RAB43 hydrolyses GTP

Stable Identifier
R-HSA-8847534
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RAB GAP USP6NL stimulates the GTPase activity of RAB43, promoting hydrolysis of GTP. Both RAB43 and USP6NL have been identifed as contributing to the retrograde transport of Shiga toxin to the Golgi, however the details of their roles remain to be elucidated (Fuchs et al, 2007; Haas et al, 2007; reviewed in Pfeffer, 2011).

Literature References
PubMed ID Title Journal Year
21421921 Entry at the trans-face of the Golgi

Pfeffer, SR

Cold Spring Harb Perspect Biol 2011
17562788 Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

Fuchs, E, Haas, AK, Spooner, RA, Yoshimura, S, Lord, JM, Barr, FA

J. Cell Biol. 2007
17684057 Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

Haas, AK, Yoshimura, S, Stephens, DJ, Preisinger, C, Fuchs, E, Barr, FA

J. Cell. Sci. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of RAB43:GTP:USP6NL [trans-Golgi network membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created