RAB43:GTP binds USP8NL

Stable Identifier
R-HSA-8847537
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RAB43 contributes to the maintenance of Golgi structure and is required for the RAB6-dependent retrograde trafficking of Shiga toxin (Fuchs et al, 2007; Haas et al, 2007). RAB43 appears to be localized to the cis side of the Golgi, so the details of how and when it affects Shiga transport remain to be clarified (Dejgaard et al, 2007). Screens of human cells identified USP6NL as a RAB43-specific GTPase activating (GAP) protein that is also implicated in Shiga trafficking (Fuchs et al, 2007; Haas et al, 2007; reviewed in Pfeffer, 2011).

Literature References
PubMed ID Title Journal Year
18664496 Rab18 and Rab43 have key roles in ER-Golgi trafficking

Dejgaard, SY, Murshid, A, Erman, A, Kizilay, O, Verbich, D, Lodge, R, Dejgaard, K, Ly-Hartig, TB, Pepperkok, R, Simpson, JC, Presley, JF

J. Cell. Sci. 2008
17562788 Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

Fuchs, E, Haas, AK, Spooner, RA, Yoshimura, S, Lord, JM, Barr, FA

J. Cell Biol. 2007
21421921 Entry at the trans-face of the Golgi

Pfeffer, SR

Cold Spring Harb Perspect Biol 2011
17684057 Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

Haas, AK, Yoshimura, S, Stephens, DJ, Preisinger, C, Fuchs, E, Barr, FA

J. Cell. Sci. 2007
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created