Reactome | PKP4 [cornified envelope]

PKP4 [cornified envelope]

Stable Identifier

R-HSA-8847721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cornified envelope

Synonyms

Plakophilin-4, PKP4_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of the cornified envelope (Homo sapiens)
    - Plasma membrane resorption (Homo sapiens)
      - Mature cornified envelope [cornified envelope] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [cornified envelope] (Homo sapiens)
        
        No FGN-Cornified envelope [cornified envelope] (Homo sapiens)
        
        No FGN-early cornified envelope [cornified envelope] (Homo sapiens)
        
        Keratin tonofilament:Desmosome network [cornified envelope] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [cornified envelope] (Homo sapiens)
        
        Desmosome [cornified envelope] (Homo sapiens)
        
        Plakophilins [cornified envelope] (Homo sapiens)
        
        PKP4 [cornified envelope] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99569 PKP4

Gene Names

PKP4

Chain

chain:1-1192

Reference Genes

BioGPS Gene:8502 PKP4

COSMIC (genes):PKP4 PKP4

CTD Gene:8502 PKP4

dbSNP Gene:8502 PKP4

ENSEMBL:ENSG00000144283 PKP4

HGNC:9026 PKP4

KEGG:hsa:8502 PKP4

Monarch:8502 PKP4

NCBI Gene:8502 PKP4

OMIM:604276 PKP4

UCSC:Q99569 PKP4

Reference Transcript

Participates

as a member of

Plakophilins [cornified envelope] (Homo sapiens)

Other forms of this molecule

PKP4 [plasma membrane]

Inferred To

Pkp4 [cornified envelope] (Mus musculus)

Pkp4 [cornified envelope] (Rattus norvegicus)

PKP4 [cornified envelope] (Bos taurus)

PKP4 [cornified envelope] (Canis familiaris)

PKP4 [cornified envelope] (Sus scrofa)

Cross References

ENSEMBL

ENST00000389759, ENST00000389757, ENSP00000374407, ENSP00000374409, ENSG00000144283

OpenTargets

ENSG00000144283

GeneCards

PKP4

HPA

ENSG00000144283-PKP4

PRO

Q99569

Pharos - Targets

Q99569

GlyGen

Q99569

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.684	4
UniProt:Q96RT1 ERBIN	1	ERBIN [plasma membrane] (R-HSA-1358718)	0.621	4
UniProt:Q12959 DLG1	4	DLG1 [plasma membrane] (R-HSA-375977) DLG1 [cytosol] (R-HSA-416332) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593)	0.609	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.491	2

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