Reactome | PKP4 [cornified envelope]

PKP4 [cornified envelope]

Stable Identifier

R-HSA-8847721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cornified envelope

Synonyms

Plakophilin-4, PKP4_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of the cornified envelope (Homo sapiens)
    - Plasma membrane resorption (Homo sapiens)
      - Mature cornified envelope [cornified envelope] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [cornified envelope] (Homo sapiens)
        
        No FGN-Cornified envelope [cornified envelope] (Homo sapiens)
        
        No FGN-early cornified envelope [cornified envelope] (Homo sapiens)
        
        Keratin tonofilament:Desmosome network [cornified envelope] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [cornified envelope] (Homo sapiens)
        
        Desmosome [cornified envelope] (Homo sapiens)
        
        Plakophilins [cornified envelope] (Homo sapiens)
        
        PKP4 [cornified envelope] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99569 PKP4

Gene Names

PKP4

Chain

chain:1-1192

Reference Genes

BioGPS Gene:8502 PKP4

COSMIC (genes):PKP4 PKP4

CTD Gene:8502 PKP4

dbSNP Gene:8502 PKP4

ENSEMBL:ENSG00000144283 PKP4

HGNC:9026 PKP4

KEGG Gene (Homo sapiens):8502 PKP4

Monarch:8502 PKP4

NCBI Gene:8502 PKP4

OMIM:604276 PKP4

UCSC:Q99569 PKP4

Reference Transcript

Other Identifiers

0001990301

0101340673

11743914_a_at

11754620_s_at

11756270_x_at

11756548_s_at

16886757

201927_s_at

201928_at

201929_s_at

240379_at

2511825

2511826

2511861

2511876

2511889

2511897

2511898

2511901

2511906

2511907

2511908

2511909

2511910

2511911

2511920

2511921

2511922

2511930

2511931

2511932

2511940

2511941

2511942

2511945

2511951

2511952

2511957

2511958

2511961

2511970

2511973

2511974

2511975

2511976

2511977

2511978

2511979

2511993

2525495

3228006

39788_at

50254_at

64323_at

74806_s_at

78293_at

8045860

8502

A_14_P135068

A_14_P200730

A_33_P3288110

GE80528

GO:0000922

GO:0001533

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005819

GO:0005856

GO:0005886

GO:0005911

GO:0005912

GO:0007043

GO:0007049

GO:0007155

GO:0007267

GO:0008150

GO:0008219

GO:0009898

GO:0014069

GO:0016020

GO:0022607

GO:0030054

GO:0030057

GO:0030154

GO:0030155

GO:0030496

GO:0031424

GO:0032467

GO:0034330

GO:0043226

GO:0043547

GO:0044291

GO:0045296

GO:0048471

GO:0048856

GO:0051233

GO:0051301

GO:0070268

GO:0072686

GO:0098609

Hs.132860.0.A1_3p_at

Hs.152151.0.S1_3p_a_at

Hs.152151.0.S3_3p_at

ILMN_1661325

ILMN_1749410

PH_hs_0007967

PH_hs_0040438

TC02000960.hg

X81889_at

g6806894_3p_a_at

Participant Of

hasMember

Plakophilins [cornified envelope]

Other forms of this molecule

PKP4 [plasma membrane]

Inferred To

Pkp4 [cornified envelope] (Mus musculus)

PKP4 [cornified envelope] (Sus scrofa)

Cross References

RefSeq

NP_001291898.1, NP_001005476.1, XP_011510318.1, NP_001291899.1, NP_003619.2

OpenTargets

ENSG00000144283

GeneCards

Q99569

HPA

ENSG00000144283-PKP4

Ensembl

ENSP00000374409, ENST00000389759, ENSP00000374407, ENSG00000144283, ENST00000389757

PRO

Q99569

Orphanet

27558

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.684	4
UniProt:Q96RT1 ERBIN	1	ERBIN [plasma membrane] (R-HSA-1358718)	0.621	4
UniProt:Q12959 DLG1	4	DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [cytosol] (R-HSA-416332) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [plasma membrane] (R-HSA-375977)	0.609	3
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3