PNPLA7 hydrolyzes LysoPtdCho

Stable Identifier
R-HSA-8847912
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PNPLA7 (Patatin-like phospholipase domain-containing protein 7, also known as NRE - NTE-related esterase) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of LysoPtcCho (lysophosphatidylcholine) to GPCho (glycerophosphocholine) and LCFA (long chain fatty acid). The human enzyme is expressed most abundantly in prostate, pancreas, and adipose tissues (Wilson et al. 2006). Its location and enzymatic activity have been inferrred from the properties of its mouse homologue (Kienesberger et al. 2008).

Literature References
PubMed ID Title Journal Year
16799181 Characterization of the human patatin-like phospholipase family

Wilson, PA, Gardner, SD, Lambie, NM, Commans, SA, Crowther, DJ

J. Lipid Res. 2006
18086666 Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase

Kienesberger, PC, Lass, A, Preiss-Landl, K, Wolinski, H, Kohlwein, SD, Zimmermann, R, Zechner, R

J. Biol. Chem. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lysophospholipase activity of PNPLA7 [endoplasmic reticulum membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created