Reactome: A Curated Pathway Database

ERBB2 Activates PTK6 Signaling

Stable Identifier
R-HSA-8847993
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

PTK6 (BRK) is activated downstream of ERBB2 (HER) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et al. 1996) and MET (Castro and Lange 2010). However, it is not clear if MET and EGFR activate PTK6 directly or act through ERBB2, since it is known that ERBB2 forms heterodimers with EGFR (Spivak-Kroizman et al. 1992), and MET can heterodimerize with both EGFR and ERBB2 (Tanizaki et al. 2011).

Literature References
Participants
Participant Of
Orthologous Events
Cross References