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STAP2 [cytosol]
Stable Identifier
R-HSA-8848028
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Signal-transducing adaptor protein 2, STAP-2, BRK substrate
Locations in the PathwayBrowser for interactor UniProt:Q99836 MYD88
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Activates STAT3 (Homo sapiens)
Activated PTK6 binds STAP2 (Homo sapiens)
STAP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UGK3 STAP2
Gene Names
STAP2, BKS
Chain
chain:1-403
Reference Genes
BioGPS Gene:55620 STAP2
COSMIC (genes):STAP2 STAP2
CTD Gene:55620 STAP2
dbSNP Gene:55620 STAP2
ENSEMBL:ENSG00000178078 STAP2
ENSEMBL_homo_sapiens_GENE:ENSG00000178078.12 STAP2
HGNC:30430 STAP2
KEGG Gene (Homo sapiens):55620 STAP2
Monarch:55620 STAP2
NCBI Gene:55620 STAP2
OMIM:607881 STAP2
UCSC:Q9UGK3 STAP2
Reference Transcript
RefSeq:NM_001013841.1 STAP2
RefSeq:NM_017720.2 STAP2
Other Identifiers
11721943_a_at
11736317_x_at
16867278
221610_PM_s_at
221610_s_at
3846710
3846711
3846712
3846713
3846714
3846715
3846716
3846717
3846718
3846719
3846720
3846722
3846724
3846726
3846727
3846728
3846730
55620
63788_at
8032789
GE87437
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0035591
GO:0060090
HMNXSV003024376
HMNXSV003036735
ILMN_1657631
ILMN_1704500
ILMN_2281529
ILMN_2384237
TC19001061.hg
g12653994_3p_a_at
Participates
as a component of
p-Y342-PTK6:STAP2 [cytosol] (Homo sapiens)
as an input of
Activated PTK6 binds STAP2 (Homo sapiens)
Other forms of this molecule
p-Y250-STAP2 [plasma membrane]
Inferred To
STAP2 [cytosol]
(Bos taurus)
STAP2 [cytosol]
(Sus scrofa)
Stap2 [cytosol]
(Mus musculus)
Stap2 [cytosol]
(Rattus norvegicus)
stap2a [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_001013863.1
,
NP_060190.2
OpenTargets
ENSG00000178078
HPA
ENSG00000178078-STAP2
GeneCards
Q9UGK3
Ensembl
ENSP00000471052
,
ENSP00000468927
,
ENSG00000178078
,
ENST00000600324
,
ENST00000594605
PRO
Q9UGK3
Pharos - Targets
Q9UGK3
PDB
2EL8
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.623
7
UniProt:Q9ULC6 PADI1
2
PADI1 [cytosol]
(R-HSA-1183112)
PADI1 [nucleoplasm]
(R-HSA-6793445)
0.589
2
UniProt:P42681 TXK
3
TXK [cytosol]
(R-HSA-3448733)
p-Y91,Y420-TXK [cytosol]
(R-HSA-3448740)
p-Y420-TXK [cytosol]
(R-HSA-3448734)
0.556
3
UniProt:P42229 STAT5A
4
STAT5A [nucleoplasm]
(R-HSA-9701901)
p-Y694-STAT5A [nucleoplasm]
(R-HSA-507995)
p-Y694-STAT5A [cytosol]
(R-HSA-507936)
STAT5A [cytosol]
(R-HSA-380747)
0.556
11
UniProt:P51451 BLK
2
MyrG2-BLK [plasma membrane]
(R-HSA-9606871)
BLK [cytosol]
(R-HSA-983580)
0.556
3
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.556
3
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P51692 STAT5B
4
STAT5B [cytosol]
(R-HSA-380737)
p-Y699-STAT5B [cytosol]
(R-HSA-507939)
p-Y699-STAT5B [nucleoplasm]
(R-HSA-508016)
p-STAT5B [cytosol]
(R-HSA-8983127)
0.524
10
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.524
3
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