IL37 binds IL18R1

Stable Identifier
R-HSA-8848335
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
IL-37 binds IL-18R1
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Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL-37, IL-1F7) is a member of the IL-1 family. There are five isoforms of IL37 (a e) of which transcript IL-37 is known to be functional (Sharma et al. 2008). This isoform is represented in UniProt as the canonical form of IL-37 and in Reactome as the full length, unprocessed form of IL-37. Like several other IL-1 family members, IL-37 is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function. (Kumar et al. 2002). Both full length and processed IL-37 can bind the Interleukin 18 receptor 1 (IL-18R1) but binding of processed IL-37 is more effective (Shi et al. 2003, Kumar et al. 2002). Subsequently, Single Ig IL-1 related receptor (SIGIRR, TIR 8,IL-1R8) is recruited and facilitates the suppression of cytokine production in several types of immune cells resulting in reduced inflammation.

Literature References
PubMed ID Title Journal Year
12809600 Mechanisms of TGF-beta signaling from cell membrane to the nucleus

Shi, Y, Massague, J

Cell 2003
18390730 The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines

Sharma, S, Kulk, N, Nold, MF, Gräf, R, Kim, SH, Reinhardt, D, Dinarello, CA, Bufler, P

J. Immunol. 2008
12096920 Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production

Kumar, S, Hanning, CR, Brigham-Burke, MR, Rieman, DJ, Lehr, R, Khandekar, S, Kirkpatrick, RB, Scott, GF, Lee, JC, Lynch, FJ, Gao, W, Gambotto, A, Lotze, MT

Cytokine 2002
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