Reactome | PNPLA4 hydrolyzes TAG

PNPLA4 hydrolyzes TAG

Stable Identifier

R-HSA-8848338

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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PNPLA4 (patatin-like phospholipase domain-containing protein 4, also known as GS2 and iPLA2(eta)) catalyzes the hydrolysis of TAG (triacylglycerol) to DAG (diacylglycerol) and one molecule of LCFA (long chain fatty acid). The enzyme also has transacylase activity not annotated here (Gao and Simon 2007; Jenkins et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15364929	Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities Gibson, B, Yan, W, Sims, HF, Gross, RW, Jenkins, CM, Mancuso, DJ	J Biol Chem	2004
17603008	A comparative study of human GS2, its paralogues, and its rat orthologue Simon, M, Gao, JG	Biochem. Biophys. Res. Commun.	2007