PNPLA4 hydrolyzes TAG

Stable Identifier
R-HSA-8848338
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PNPLA4 (patatin-like phospholipase domain-containing protein 4, also known as GS2 and iPLA2(eta)) catalyzes the hydrolysis of TAG (triacylglycerol) to DAG (diacylglycerol) and one molecule of LCFA (long chain fatty acid). The enzyme also has transacylase activity not annotated here (Gao and Simon 2007; Jenkins et al. 2004).

Literature References
PubMed ID Title Journal Year
17603008 A comparative study of human GS2, its paralogues, and its rat orthologue

Gao, JG, Simon, M

Biochem. Biophys. Res. Commun. 2007
15364929 Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

Jenkins, CM, Mancuso, DJ, Yan, W, Sims, HF, Gibson, B, Gross, RW

J Biol Chem 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
triglyceride lipase activity of PNPLA4 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created