PNPLA4 hydrolyzes TAG

Stable Identifier
R-HSA-8848338
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
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PNPLA4 hydrolyzes TAG
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PNPLA4 (patatin-like phospholipase domain-containing protein 4, also known as GS2 and iPLA2(eta)) catalyzes the hydrolysis of TAG (triacylglycerol) to DAG (diacylglycerol) and one molecule of LCFA (long chain fatty acid). The enzyme also has transacylase activity not annotated here (Gao and Simon 2007; Jenkins et al. 2004).

Literature References
PubMed ID Title Journal Year
17603008 A comparative study of human GS2, its paralogues, and its rat orthologue

Gao, JG, Simon, M

Biochem. Biophys. Res. Commun. 2007
15364929 Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

Jenkins, CM, Mancuso, DJ, Yan, W, Sims, HF, Gibson, B, Gross, RW

J Biol Chem 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
triglyceride lipase activity of PNPLA4 [cytosol]
Physical Entity
PNPLA4 [cytosol]
Activity
triglyceride lipase activity (0004806)
Orthologous Events
PNPLA4 hydrolyzes TAG (Bos taurus)
PNPLA4 hydrolyzes TAG (Canis familiaris)
PNPLA4 hydrolyzes TAG (Danio rerio)
PNPLA4 hydrolyzes TAG (Gallus gallus)
PNPLA4 hydrolyzes TAG (Plasmodium falciparum)
PNPLA4 hydrolyzes TAG (Rattus norvegicus)
PNPLA4 hydrolyzes TAG (Sus scrofa)
PNPLA4 hydrolyzes TAG (Xenopus tropicalis)
Authored
D'Eustachio, P  (2015-12-07)
Reviewed
Jassal, B  (2016-01-29)
Created
D'Eustachio, P  (2015-12-07)