IL18:IL18R1 binds IL18RAP

Stable Identifier
R-HSA-8848395
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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IL18:IL18R1 binds IL18RAP
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Interleukin-18/Interleukin-18 receptor 1 (IL18:IL18R1) complex binds Interleukin-18 receptor accessory protein (IL18RAP, IL18 receptor beta chain), forming a high-affinity signaling complex (Born et al. 1998, Debets et al. 2001). This IL18RAP subunit seems to be necessary for the signal transduction (Kim et al. 2001).
Literature References
PubMed ID Title Journal Year
9792649 Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling

Bird, TA, Born, TL, Thomassen, E, Sims, JE

J. Biol. Chem. 1998
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
IL18BP:IL37,IL37(?-218) [extracellular region] (Homo sapiens)
Orthologous Events
IL18:IL18R1 binds IL18RAP (Bos taurus)
IL18:IL18R1 binds IL18RAP (Canis familiaris)
IL18:IL18R1 binds IL18RAP (Gallus gallus)
IL18:IL18R1 binds IL18RAP (Mus musculus)
IL18:IL18R1 binds IL18RAP (Rattus norvegicus)
IL18:IL18R1 binds IL18RAP (Sus scrofa)
IL18:IL18R1 binds IL18RAP (Xenopus tropicalis)
Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Created
Jupe, S  (2015-12-08)
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