Activated PTK6 binds CDKN1B

Stable Identifier
R-HSA-8848414
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated PTK6 (BRK) binds to CDKN1B (p27KIP1) that is in a complex with CDK4 and cyclin D1 (CCND1). Since PTK6 increases cyclin E1 (CCNE1) levels downstream of ERBB2 while decreasing CDKN1B levels, PTK6 probably also associates with CDKN1B bound to the complex of CCNE1 and CDK2 (Xiang et al. 2008).

Literature References
PubMed ID Title Journal Year
18719096 Brk is coamplified with ErbB2 to promote proliferation in breast cancer

Xiang, B, Chatti, K, Qiu, H, Lakshmi, B, Krasnitz, A, Hicks, J, Yu, M, Miller, WT, Muthuswamy, SK

Proc. Natl. Acad. Sci. U.S.A. 2008
25733683 Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4

Patel, P, Asbach, B, Shteyn, E, Gomez, C, Coltoff, A, Bhuyan, S, Tyner, AL, Wagner, R, Blain, SW

Mol. Cell. Biol. 2015
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created