Reactome | PLA2s hydrolyze phospholipids at the Golgi membrane

PLA2s hydrolyze phospholipids at the Golgi membrane

Stable Identifier

R-HSA-8848484

Type

Reaction

Species

Homo sapiens

Compartment

Golgi membrane

Locations in the PathwayBrowser

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Summation

Phospholipase A (PLA2) hydrolyzes the sn-2 position of phospholipids, releasing a fatty acid and a lysophospholipid (reviewed in Six and Dennis, 2000; Kudo and Murakami, 2002). A number studies have highlighted roles for a number of PLA2s in the maintenance of Golgi function and structure (de Figueiredo et al, 1998; de Figueiredo et al, 1999). PLAs may generate phospholipid and fatty acid products that recruit effectors of Golgi function and trafficking to the membrane or that affect downstream signaling pathways. Alternately, PLA2s may contribute directly to tubule formation at the Golgi through the production of the membrane-curvature inducing lysophospholipid (reviewed in Bechler et al, 2012). PLA2s may be recruited to the Golgi in response to changes in Ca2+ and/or cargo concentration that occur as a result of secretory traffic (Micaroni et al, 2010; San Pietro et al, 2009; Pulvirenti et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
20420828	Synchronous intra-Golgi transport induces the release of Ca2+ from the Golgi apparatus Micaroni, M, Perinetti, G, Di Giandomenico, D, Bianchi, K, Spaar, A, Mironov, AA	Exp. Cell Res.	2010
22130221	A PLA1-2 punch regulates the Golgi complex Bechler, ME, de Figueiredo, P, Brown, WJ	Trends Cell Biol.	2012
19753100	Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport San Pietro, E, Capestrano, M, Polishchuk, EV, DiPentima, A, Trucco, A, Zizza, P, Mariggi�, S, Pulvirenti, T, Sallese, M, Tete, S, Mironov, AA, Leslie, CC, Corda, D, Luini, A, Polishchuk, RS	PLoS Biol.	2009
9671731	Evidence that phospholipase A2 activity is required for Golgi complex and trans Golgi network membrane tubulation de Figueiredo, P, Drecktrah, D, Katzenellenbogen, JA, Strang, M, Brown, WJ	Proc. Natl. Acad. Sci. U.S.A.	1998
10359595	Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists de Figueiredo, P, Polizotto, RS, Drecktrah, D, Brown, WJ	Mol. Biol. Cell	1999
11080672	The expanding superfamily of phospholipase A(2) enzymes: classification and characterization Six, DA, Dennis, EA	Biochim. Biophys. Acta	2000
18641641	A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway Pulvirenti, T, Giannotta, M, Capestrano, M, Capitani, M, Pisanu, A, Polishchuk, RS, San Pietro, E, Beznoussenko, GV, Mironov, AA, Turacchio, G, Hsu, VW, Sallese, M, Luini, A	Nat. Cell Biol.	2008
12432908	Phospholipase A2 enzymes Kudo, I, Murakami, M	Prostaglandins Other Lipid Mediat.	2002