PLA2s hydrolyze phospholipids at the Golgi membrane

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Phospholipase A (PLA2) hydrolyzes the sn-2 position of phospholipids, releasing a fatty acid and a lysophospholipid (reviewed in Six and Dennis, 2000; Kudo and Murakami, 2002). A number studies have highlighted roles for a number of PLA2s in the maintenance of Golgi function and structure (de Figueiredo et al, 1998; de Figueiredo et al, 1999). PLAs may generate phospholipid and fatty acid products that recruit effectors of Golgi function and trafficking to the membrane or that affect downstream signaling pathways. Alternately, PLA2s may contribute directly to tubule formation at the Golgi through the production of the membrane-curvature inducing lysophospholipid (reviewed in Bechler et al, 2012). PLA2s may be recruited to the Golgi in response to changes in Ca2+ and/or cargo concentration that occur as a result of secretory traffic (Micaroni et al, 2010; San Pietro et al, 2009; Pulvirenti et al, 2008).

Literature References
PubMed ID Title Journal Year
20420828 Synchronous intra-Golgi transport induces the release of Ca2+ from the Golgi apparatus

Micaroni, M, Perinetti, G, Di Giandomenico, D, Bianchi, K, Spaar, A, Mironov, AA

Exp. Cell Res. 2010
22130221 A PLA1-2 punch regulates the Golgi complex

Bechler, ME, de Figueiredo, P, Brown, WJ

Trends Cell Biol. 2012
19753100 Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport

San Pietro, E, Capestrano, M, Polishchuk, EV, DiPentima, A, Trucco, A, Zizza, P, Mariggiò, S, Pulvirenti, T, Sallese, M, Tete, S, Mironov, AA, Leslie, CC, Corda, D, Luini, A, Polishchuk, RS

PLoS Biol. 2009
9671731 Evidence that phospholipase A2 activity is required for Golgi complex and trans Golgi network membrane tubulation

de Figueiredo, P, Drecktrah, D, Katzenellenbogen, JA, Strang, M, Brown, WJ

Proc. Natl. Acad. Sci. U.S.A. 1998
10359595 Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists

de Figueiredo, P, Polizotto, RS, Drecktrah, D, Brown, WJ

Mol. Biol. Cell 1999
11080672 The expanding superfamily of phospholipase A(2) enzymes: classification and characterization

Six, DA, Dennis, EA

Biochim. Biophys. Acta 2000
18641641 A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway

Pulvirenti, T, Giannotta, M, Capestrano, M, Capitani, M, Pisanu, A, Polishchuk, RS, San Pietro, E, Beznoussenko, GV, Mironov, AA, Turacchio, G, Hsu, VW, Sallese, M, Luini, A

Nat. Cell Biol. 2008
12432908 Phospholipase A2 enzymes

Kudo, I, Murakami, M

Prostaglandins Other Lipid Mediat. 2002
Participant Of
Catalyst Activity
Catalyst Activity
phospholipase A2 activity of cPLA2s [cytosol]
Physical Entity
Orthologous Events