Phosphorylated PXN recruits the CRK complex

Stable Identifier
R-HSA-8848611
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PXN (paxillin), phosphorylated by PTK6 (BRK) on tyrosine residues Y31 and Y118, recruits CRK (CrkII) complex which acts as a guanine exchange factor (GEF) for RAC1 (Chen et al. 2004).

Literature References
PubMed ID Title Journal Year
15572663 Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin Mol. Cell. Biol. 2004
Participants
Participant Of
Orthologous Events