Activation of RAC1 by the PXN:CRK complex

Stable Identifier
R-HSA-8848618
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PTK6 (BRK) mediated phosphorylation of PXN (paxillin), which may be triggered by EGF treatment, leads to formation of the RAC1 guanyl nucleotide exchange factor complex composed of PXN and the CRK (CrkII) complex, which includes DOCK180 and ELMO1 or ELMO2. Exchange of RAC1-bound GDP for GTP results in PTK6-induced RAC1 activation, which contributes to cell migration (Chen et al. 2004).

Literature References
PubMed ID Title Journal Year
15572663 Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin Mol. Cell. Biol. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed