Reactome | p-Y362-DOK1 [cytosol]

p-Y362-DOK1 [cytosol]

Stable Identifier

R-HSA-8848784

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser for interactor UniProt:P46109 CRKL

Expand all

External Reference Information

External Reference

UniProt:Q99704 DOK1

Gene Names

DOK1

Chain

chain:1-481

Reference Genes

BioGPS Gene:1796 DOK1

COSMIC (genes):DOK1 DOK1

CTD Gene:1796 DOK1

dbSNP Gene:1796 DOK1

ENSEMBL:ENSG00000115325 DOK1

HGNC:2990 DOK1

KEGG Gene (Homo sapiens):1796 DOK1

Monarch:1796 DOK1

NCBI Gene:1796 DOK1

OMIM:602919 DOK1

UCSC:Q99704 DOK1

Reference Transcript

Other Identifiers

0005270451

11731530_a_at

11731531_x_at

11747949_a_at

11751046_a_at

11763329_a_at

16881802

1796

211121_s_at

216835_s_at

2489441

2489445

2489446

2489447

2489448

2489453

2489455

2489456

2489457

34433_at

8042917

815_at

816_g_at

A_23_P5601

A_23_P5610

GE54274

GO:0000902

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0007165

GO:0007166

GO:0007169

GO:0007265

GO:0007411

GO:0008150

GO:0030154

GO:0035556

GO:0038145

GO:0040011

GO:0043226

GO:0045742

GO:0048471

GO:0048856

ILMN_1700086

PH_hs_0005763

TC02000464.hg

U70987_at

g6606314_3p_a_at

Participant Of

output

PTK6 phosphorylates DOK1

Other forms of this molecule

DOK1 [cytosol]

Inferred To

phospho-Dok1 [cytosol] (Mus musculus)

phospho-Dok1 [cytosol] (Rattus norvegicus)

phospho-p-Y362-DOK1 [cytosol] (Sus scrofa)

phospho-Dok [cytosol] (Drosophila melanogaster)

phospho-dok1 [cytosol] (Xenopus tropicalis)

phospho-dok1b [cytosol] (Danio rerio)

Modified Residues

Name

O4'-phospho-L-tyrosine at 362

Coordinate

362

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001305797.1, NP_001184189.1, NP_001372.1

OpenTargets

ENSG00000115325

GeneCards

Q99704

HPA

ENSG00000115325-DOK1

Ensembl

ENST00000409429, ENST00000340004, ENSG00000115325, ENST00000233668, ENSP00000233668, ENSP00000387016, ENSP00000344330

PRO

Q99704

PDB

2V76

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H3Y6 SRMS	1	SRMS [cytosol] (R-HSA-3902520)	0.639	7
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:Q9JIY2	1	Cbll1 [cytosol] (R-MMU-8851646)	0.524	2
UniProt:Q9Q2G4 Q9Q2G4			0.499	2
UniProt:Q7L591-3 DOK3			0.488	2
UniProt:P46109 CRKL	2	p-CRKL [cytosol] (R-HSA-9024730) CRKL [cytosol] (R-HSA-354384)	0.488	2
UniProt:O60880 SH2D1A	1	SH2D1A [cytosol] (R-HSA-5685108)	0.462	2

Cite Us!