Reactome: A Curated Pathway Database

HIF1A,EPAS1 promote PTK6 gene expression

Stable Identifier
R-HSA-8848804
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Binding of HIF1A (HIF1-alpha) and/or EPAS1 (HIF2A) to hypoxia response elements (HREs) in the promoter region of the PTK6 (BRK) gene stimulates PTK6 transcription at hypoxia (Regan Anderson et al. 2013). EPAS1 was recently reported to cooperate with the activated glucocorticoid receptor NR3C1 (GCR) and its cofactor PELP1 in the stimulation of PTK6 transcription (Regan Anderson et al. 2016).

Literature References
Participants
Participant Of
hasEvent
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