Reactome: A Curated Pathway Database

HIF1A,EPAS1 bind PTK6 gene

Stable Identifier
R-HSA-8848812
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

HIF1A (HIF1-alpha) and/or EPAS1 (HIF2A), probably in association with other transcription factors, binds hypoxia response elements (HREs) in the promoter region of the PTK6 (BRK) gene (Regan Anderson et al. 2013). EPAS1 was recently found to cooperate with the activated glucocorticoid receptor NR3C1 (GCR) and its cofactor PELP1 in binding to the adjacent hypoxia response and glucocorticoid response PTK6 promoter elements (Regan Anderson et al. 2016).

Literature References
Participants
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