PTK6 phosphorylates ARAP1

Stable Identifier
R-HSA-8848873
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ARAP1 is implicated in the endocytosis of EGFR, as the complex formation betwen ARAP1 and CIN85 inhibits CBL-mediated targeting of EGFR to the early endosome/lysosome pathway (Yoon et al. 2011). PTK6 phosphorylates ARAP1 on tyrosine residue Y231, resulting in the inhibition of EGFR endocytosis and, hence, prolonged EGFR signaling (Kang et al. 2010).

Literature References
PubMed ID Title Journal Year
20554524 PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1

Kang, SA, Lee, ES, Yoon, HY, Randazzo, PA, Lee, ST

J. Biol. Chem. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-Y342-PTK6:ARAP1 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created