Reactome | TMX3 [plasma membrane]

TMX3 [plasma membrane]

Stable Identifier

R-HSA-8848896

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Protein disulfide-isomerase TMX3 ecNumber5.3.4.1/ecNumber, TMX3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96JJ7 TMX3

Gene Names

TMX3, KIAA1830, TXNDC10

Chain

signal peptide:1-24, chain:25-454

Reference Genes

BioGPS Gene:54495 TMX3

COSMIC (genes):TMX3 TMX3

CTD Gene:54495 TMX3

dbSNP Gene:54495 TMX3

ENSEMBL:ENSG00000166479 TMX3

ENSEMBL_homo_sapiens_GENE:ENSG00000166479.10 TMX3

HGNC:24718 TMX3

KEGG Gene (Homo sapiens):54495 TMX3

Monarch:54495 TMX3

NCBI Gene:54495 TMX3

OMIM:616102 TMX3

UCSC:Q96JJ7 TMX3

Reference Transcript

RefSeq:NM_019022.3 TMX3

Other Identifiers

11721730_at

11721731_a_at

11721732_at

11745411_a_at

11751701_a_at

11762283_x_at

1552822_PM_at

1552822_at

16855786

225302_PM_at

225302_at

3812207

3812208

3812209

3812210

3812211

3812213

3812217

3812218

3812219

3812220

3812223

3812227

3812228

3812229

3812230

3812232

3812233

3812235

3812237

3812238

3812239

3812240

3812241

3812242

48348_at

48763_at

53878_at

54495

58264_at

8023735

83929_at

A_23_P312224

A_24_P417281

A_33_P3252141

GE55626

GO:0003756

GO:0003824

GO:0005515

GO:0005783

GO:0005789

GO:0005886

GO:0009986

GO:0015035

GO:0016020

GO:0016491

GO:0016853

GO:0018171

GO:0031092

GO:0031410

GO:0036211

GO:0043226

GO:0140096

HMNXSV003017334

HMNXSV003037246

HMNXSV003039963

Hs.96900.0.S1_3p_at

Hs2.96900.1.S1_3p_at

ILMN_2047206

PH_hs_0025793

TC18000565.hg

Participates

as a member of

Platelet alpha granule membrane components that are released on degranulation [plasma membrane] (Homo sapiens)

Other forms of this molecule

TMX3 [platelet alpha granule membrane]

Inferred To

Tmx3 [plasma membrane] (Drosophila melanogaster)

Tmx3 [plasma membrane] (Mus musculus)

Tmx3 [plasma membrane] (Rattus norvegicus)

TMX3 [plasma membrane] (Bos taurus)

TMX3 [plasma membrane] (Caenorhabditis elegans)

TMX3 [plasma membrane] (Canis familiaris)

TMX3 [plasma membrane] (Danio rerio)

TMX3 [plasma membrane] (Gallus gallus)

TMX3 [plasma membrane] (Plasmodium falciparum)

TMX3 [plasma membrane] (Schizosaccharomyces pombe)

TMX3 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_061895.3

OpenTargets

ENSG00000166479

HPA

ENSG00000166479-TMX3

GeneCards

Q96JJ7

Ensembl

ENST00000562706, ENST00000299608, ENSG00000166479, ENSP00000299608, ENSP00000457262

PRO

Q96JJ7

Pharos - Targets

Q96JJ7

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6

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