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KHDRBS1 [nucleoplasm]
Stable Identifier
R-HSA-8848941
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
KH domain-containing, RNA-binding, signal transduction-associated protein 1, SAM68, Src-associated in mitosis 68 kDa protein, GAP-associated tyrosine phosphoprotein p62, p21 Ras GTPase-activating protein-associated p62
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates Proteins Involved in RNA Processing (Homo sapiens)
PTK6 binds KHDRBS1 (Homo sapiens)
KHDRBS1 [nucleoplasm] (Homo sapiens)
p-Y342-PTK6:KHDRBS1 [nucleoplasm] (Homo sapiens)
KHDRBS1 [nucleoplasm] (Homo sapiens)
PTK6 phosphorylates KHDRBS1 (Homo sapiens)
p-Y342-PTK6:KHDRBS1 [nucleoplasm] (Homo sapiens)
KHDRBS1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q07666 KHDRBS1
Gene Names
KHDRBS1, SAM68
Chain
chain:1-443
Reference Genes
BioGPS Gene:10657 KHDRBS1
COSMIC (genes):KHDRBS1 KHDRBS1
CTD Gene:10657 KHDRBS1
dbSNP Gene:10657 KHDRBS1
ENSEMBL:ENSG00000121774 KHDRBS1
HGNC:18116 KHDRBS1
KEGG Gene (Homo sapiens):10657 KHDRBS1
Monarch:10657 KHDRBS1
NCBI Gene:10657 KHDRBS1
OMIM:602489 KHDRBS1
UCSC:Q07666 KHDRBS1
Reference Transcript
RefSeq:NM_001271878.1 KHDRBS1
RefSeq:NM_006559.2 KHDRBS1
Other Identifiers
0004280487
10657
11715937_a_at
11715938_x_at
11715939_a_at
11715940_s_at
11748491_a_at
16661917
18670571
18670572
18670573
18670574
18670575
18670576
18670577
18670579
18670580
18670581
18670582
18670583
200040_PM_at
200040_at
201488_x_at
2328471
2328472
2328473
2328474
2328475
2328476
2328477
2328484
2328486
2328487
2328488
2328489
2328494
2328496
2328499
2328500
2328501
2328502
2328503
2328504
2328505
2328506
2328507
39346_at
7892901
7893709
7894115
7894518
7894790
7894951
7895003
7895241
7895411
7895710
7895932
7895943
7896005
7896200
7896331
7896358
7899654
A_23_P149012
A_23_P200386
GE58125
GO:0000003
GO:0000082
GO:0000086
GO:0000122
GO:0000278
GO:0000381
GO:0002376
GO:0003674
GO:0003676
GO:0003677
GO:0003723
GO:0003729
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006397
GO:0006412
GO:0006810
GO:0006913
GO:0007049
GO:0007165
GO:0007166
GO:0007283
GO:0008143
GO:0008150
GO:0008266
GO:0009058
GO:0016020
GO:0017124
GO:0019899
GO:0019904
GO:0030674
GO:0032991
GO:0034641
GO:0035591
GO:0042169
GO:0042802
GO:0043226
GO:0044877
GO:0045892
GO:0045948
GO:0046831
GO:0046833
GO:0048024
GO:0050852
GO:0070618
GO:1990782
HMNXSV003027870
HMNXSV003050297
ILMN_1654561
ILMN_2076640
M88108_at
PH_hs_0006592
TC01000417.hg
g12653852_3p_a_at
g12653852_3p_x_at
g5730026_3p_at
Participates
as an input of
PTK6 binds KHDRBS1 (Homo sapiens)
as a component of
p-Y342-PTK6:KHDRBS1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
Inferred To
KHDRBS1 [nucleoplasm]
(Bos taurus)
KHDRBS1 [nucleoplasm]
(Sus scrofa)
khdrbs1b [nucleoplasm]
(Danio rerio)
Khdrbs1 [nucleoplasm]
(Mus musculus)
Khdrbs1 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001258807.1
,
NP_006550.1
OpenTargets
ENSG00000121774
GeneCards
Q07666
HPA
ENSG00000121774-KHDRBS1
Ensembl
ENSP00000313829
,
ENSG00000121774
,
ENST00000327300
,
ENSP00000417731
,
ENST00000492989
PRO
Q07666
PDB
2XA6
,
3QHE
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.868
8
UniProt:P06241 FYN
6
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-Y420-FYN [cytosol]
(R-HSA-391821)
FYN [cytosol]
(R-HSA-200917)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
0.848
8
UniProt:P09651 HNRNPA1
1
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
0.839
9
UniProt:P06239 LCK
4
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
LCK [cytosol]
(R-HSA-167609)
p-Y394-LCK [cytosol]
(R-HSA-202308)
0.835
5
UniProt:P08631 HCK
2
HCK [cytosol]
(R-HSA-167708)
p-HCK [cytosol]
(R-HSA-9676060)
0.78
4
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.756
4
UniProt:P19174 PLCG1
6
PLCG1 [plasma membrane]
(R-HSA-167682)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.692
3
UniProt:P61978 HNRNPK
2
HNRNPK [nucleoplasm]
(R-HSA-71945)
SUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
0.668
3
UniProt:O75554 WBP4
1
WBP4 [nucleoplasm]
(R-HSA-8867895)
0.667
5
UniProt:P25054 APC
86
APC C1410* [cytosol]
(R-HSA-9666925)
APC R213* [cytosol]
(R-HSA-9666924)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
APC G1312* [cytosol]
(R-HSA-9666931)
APC R283* [cytosol]
(R-HSA-9666988)
APC Q1367* [cytosol]
(R-HSA-9666989)
APC E1353* [cytosol]
(R-HSA-9666990)
APC R332* [cytosol]
(R-HSA-9666991)
APC K993* [cytosol]
(R-HSA-9666984)
APC R876* [cytosol]
(R-HSA-9666985)
APC R302* [cytosol]
(R-HSA-9666986)
APC E1309* [cytosol]
(R-HSA-9666987)
APC Y935* [cytosol]
(R-HSA-9666980)
APC E1286* [cytosol]
(R-HSA-9666981)
APC Q1378* [cytosol]
(R-HSA-9666982)
APC R554* [cytosol]
(R-HSA-9666983)
APC S1356* [cytosol]
(R-HSA-9666976)
APC R232* [cytosol]
(R-HSA-9666977)
APC E1379* [cytosol]
(R-HSA-9666978)
APC E984* [cytosol]
(R-HSA-9666979)
APC R1114* [cytosol]
(R-HSA-9666996)
APC S1282* [cytosol]
(R-HSA-9666997)
APC Q1328* [cytosol]
(R-HSA-9666998)
APC E1295* [cytosol]
(R-HSA-9666992)
APC E1151* [cytosol]
(R-HSA-9666993)
APC E1322* [cytosol]
(R-HSA-9666994)
APC E1345* [cytosol]
(R-HSA-9666995)
APC K1308* [cytosol]
(R-HSA-9666956)
APC S1344* [cytosol]
(R-HSA-9666957)
APC E1577* [cytosol]
(R-HSA-9666958)
APC Q1127* [cytosol]
(R-HSA-9666959)
APC E1464* [cytosol]
(R-HSA-9666952)
APC E1317* [cytosol]
(R-HSA-9666953)
APC G1309Dfs*4 [cytosol]
(R-HSA-4791251)
APC W1049* [cytosol]
(R-HSA-9666954)
APC Q1429* [cytosol]
(R-HSA-9666955)
APC L1564* [cytosol]
(R-HSA-9666948)
APC Q1294* [cytosol]
(R-HSA-9666949)
APC K1363* [cytosol]
(R-HSA-9666950)
APC E1408* [cytosol]
(R-HSA-9666951)
APC E1284* [cytosol]
(R-HSA-9666944)
APC E1374* [cytosol]
(R-HSA-9666945)
APC Q767* [cytosol]
(R-HSA-9666946)
APC E941* [cytosol]
(R-HSA-9666947)
APC Q1303* [cytosol]
(R-HSA-9666972)
APC S943* [cytosol]
(R-HSA-9666973)
APC E1306* [cytosol]
(R-HSA-9666975)
APC S895* [cytosol]
(R-HSA-9666969)
APC S1315* [cytosol]
(R-HSA-9666970)
APC G1412* [cytosol]
(R-HSA-9666971)
APC Y1376* [cytosol]
(R-HSA-9666964)
APC Q886* [cytosol]
(R-HSA-9666965)
APC S1392* [cytosol]
(R-HSA-9666966)
APC S1539* [cytosol]
(R-HSA-9666967)
APC E1451* [cytosol]
(R-HSA-9666960)
APC E1397* [cytosol]
(R-HSA-9666961)
APC Q1406* [cytosol]
(R-HSA-9666962)
APC E1544* [cytosol]
(R-HSA-9666963)
APC F1197* [cytosol]
(R-HSA-5246655)
APC Q1338* [cytosol]
(R-HSA-5246654)
APC S811* [cytosol]
(R-HSA-5246652)
APC I1417 fs*2 [cytosol]
(R-HSA-5246651)
APC E1554* [cytosol]
(R-HSA-5246648)
p-ub-APC [cytosol]
(R-HSA-3009421)
K63polyUb-APC [cytosol]
(R-HSA-5246690)
APC [nucleoplasm]
(R-HSA-3361755)
APC(1-777) [cytosol]
(R-HSA-2976014)
APC(778-2843) [cytosol]
(R-HSA-2976013)
APC [cytosol]
(R-HSA-2976015)
0.667
4
UniProt:O95365 ZBT7A
0.649
9
UniProt:P07948 LYN
7
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
LYN [plasma membrane]
(R-HSA-197943)
LYN [cytosol]
(R-HSA-354251)
p-Y396-LYN [plasma membrane]
(R-HSA-2454229)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
0.609
2
UniProt:P12931 SRC
6
p-Y416-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.573
3
UniProt:O60861 GAS7
0.564
2
UniProt:O75525 KHDRBS3
2
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
0.553
2
UniProt:Q12805 EFEMP1
1
EFEMP1 [extracellular region]
(R-HSA-2161393)
0.553
2
UniProt:P38159 RBMX
2
RBMX [cytosol]
(R-HSA-9715135)
RBMX [nucleoplasm]
(R-HSA-71939)
0.553
2
UniProt:Q8N3X1 FNBP4
0.544
4
UniProt:P51531 SMARCA2
1
SMARCA2 [nucleoplasm]
(R-HSA-389256)
0.524
2
UniProt:P15498 VAV1
5
p-Y174-VAV1 [cytosol]
(R-HSA-437946)
VAV1 [plasma membrane]
(R-HSA-1045153)
VAV1 [cytosol]
(R-HSA-195066)
p-Y142,Y160,Y174-VAV1 [plasma membrane]
(R-HSA-389323)
p-Y-VAV1 [cytosol]
(R-HSA-9029087)
0.524
3
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