Reactome | KHDRBS1 [nucleoplasm]

KHDRBS1 [nucleoplasm]

Stable Identifier

R-HSA-8848941

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

KH domain-containing, RNA-binding, signal transduction-associated protein 1, SAM68, Src-associated in mitosis 68 kDa protein, GAP-associated tyrosine phosphoprotein p62, p21 Ras GTPase-activating protein-associated p62

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q07666 KHDRBS1

Gene Names

KHDRBS1, SAM68

Chain

chain:1-443

Reference Genes

BioGPS Gene:10657 KHDRBS1

COSMIC (genes):KHDRBS1 KHDRBS1

CTD Gene:10657 KHDRBS1

dbSNP Gene:10657 KHDRBS1

ENSEMBL:ENSG00000121774 KHDRBS1

HGNC:18116 KHDRBS1

KEGG Gene (Homo sapiens):10657 KHDRBS1

Monarch:10657 KHDRBS1

NCBI Gene:10657 KHDRBS1

OMIM:602489 KHDRBS1

UCSC:Q07666 KHDRBS1

Reference Transcript

Other Identifiers

0004280487

10657

11715937_a_at

11715938_x_at

11715939_a_at

11715940_s_at

11748491_a_at

16661917

18670571

18670572

18670573

18670574

18670575

18670576

18670577

18670579

18670580

18670581

18670582

18670583

18670584

200040_PM_at

200040_at

201488_x_at

2328473

2328474

2328475

2328476

2328477

2328484

2328486

2328487

2328488

2328489

2328494

2328496

2328499

2328500

2328501

2328502

2328503

2328504

2328505

2328506

2328507

2328508

39346_at

7892901

7893709

7894115

7894518

7894790

7894951

7895003

7895241

7895411

7895710

7895932

7895943

7896005

7896200

7896331

7896358

7899654

A_23_P149012

A_23_P200386

GE58125

GO:0000003

GO:0000082

GO:0000086

GO:0000122

GO:0000278

GO:0000381

GO:0003674

GO:0003676

GO:0003677

GO:0003723

GO:0005070

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006397

GO:0006412

GO:0006810

GO:0006913

GO:0007049

GO:0007165

GO:0007166

GO:0007283

GO:0008143

GO:0008150

GO:0008266

GO:0009058

GO:0009967

GO:0016020

GO:0017124

GO:0019904

GO:0030674

GO:0032991

GO:0034641

GO:0042802

GO:0043226

GO:0044877

GO:0045892

GO:0045948

GO:0046831

GO:0046833

GO:0048024

GO:0070618

ILMN_1654561

ILMN_2076640

M88108_at

PH_hs_0006592

TC01000417.hg

g12653852_3p_a_at

g12653852_3p_x_at

g5730026_3p_at

Participant Of

input

PTK6 binds KHDRBS1

hasComponent

p-Y342-PTK6:KHDRBS1 [nucleoplasm]

Other forms of this molecule

p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]

p-Y435,Y440,Y443-KHDRBS1 [cytosol]

Inferred To

Dmel\CG4021 [nucleoplasm] (Drosophila melanogaster)

KHDRBS1 [nucleoplasm] (Bos taurus)

KHDRBS1 [nucleoplasm] (Sus scrofa)

qkr58E-2 [nucleoplasm] (Drosophila melanogaster)

khdrbs1b [nucleoplasm] (Danio rerio)

qkr58E-1 [nucleoplasm] (Drosophila melanogaster)

Homologues of KHDRBS1 [nucleoplasm] (Drosophila melanogaster)

qkr58E-3 [nucleoplasm] (Drosophila melanogaster)

cg10384 [nucleoplasm] (Drosophila melanogaster)

khdrbs1 [nucleoplasm] (Xenopus tropicalis)

Khdrbs1 [nucleoplasm] (Mus musculus)

Khdrbs1 [nucleoplasm] (Rattus norvegicus)

cg3927 [nucleoplasm] (Drosophila melanogaster)

nsr [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_006550.1, NP_001258807.1

OpenTargets

ENSG00000121774

GeneCards

Q07666

HPA

ENSG00000121774-KHDRBS1

Ensembl

ENST00000327300, ENSP00000313829, ENST00000492989, ENSG00000121774, ENSP00000417731

PRO

Q07666

PDB

2XA6, 3QHE

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.868	8
UniProt:P06241 FYN	6	p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410)	0.848	8
UniProt:P09651 HNRNPA1	1	HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.839	9
UniProt:P06239 LCK	4	p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.835	5
UniProt:P08631 HCK	1	HCK [cytosol] (R-HSA-167708)	0.78	4
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.756	4
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.692	3
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) SUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.668	3
UniProt:P25054 APC	86	APC C1410* [cytosol] (R-HSA-9666925) APC R213* [cytosol] (R-HSA-9666924) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930) APC G1312* [cytosol] (R-HSA-9666931) APC R283* [cytosol] (R-HSA-9666988) APC Q1367* [cytosol] (R-HSA-9666989) APC E1353* [cytosol] (R-HSA-9666990) APC R332* [cytosol] (R-HSA-9666991) APC K993* [cytosol] (R-HSA-9666984) APC R876* [cytosol] (R-HSA-9666985) APC R302* [cytosol] (R-HSA-9666986) APC E1309* [cytosol] (R-HSA-9666987) APC Y935* [cytosol] (R-HSA-9666980) APC E1286* [cytosol] (R-HSA-9666981) APC Q1378* [cytosol] (R-HSA-9666982) APC R554* [cytosol] (R-HSA-9666983) APC S1356* [cytosol] (R-HSA-9666976) APC R232* [cytosol] (R-HSA-9666977) APC E1379* [cytosol] (R-HSA-9666978) APC E984* [cytosol] (R-HSA-9666979) APC R1114* [cytosol] (R-HSA-9666996) APC S1282* [cytosol] (R-HSA-9666997) APC Q1328* [cytosol] (R-HSA-9666998) APC E1295* [cytosol] (R-HSA-9666992) APC E1151* [cytosol] (R-HSA-9666993) APC E1322* [cytosol] (R-HSA-9666994) APC E1345* [cytosol] (R-HSA-9666995) APC K1308* [cytosol] (R-HSA-9666956) APC S1344* [cytosol] (R-HSA-9666957) APC E1577* [cytosol] (R-HSA-9666958) APC Q1127* [cytosol] (R-HSA-9666959) APC E1464* [cytosol] (R-HSA-9666952) APC E1317* [cytosol] (R-HSA-9666953) APC G1309Dfs4 [cytosol] (R-HSA-4791251) APC W1049 [cytosol] (R-HSA-9666954) APC Q1429* [cytosol] (R-HSA-9666955) APC L1564* [cytosol] (R-HSA-9666948) APC Q1294* [cytosol] (R-HSA-9666949) APC K1363* [cytosol] (R-HSA-9666950) APC E1408* [cytosol] (R-HSA-9666951) APC E1284* [cytosol] (R-HSA-9666944) APC E1374* [cytosol] (R-HSA-9666945) APC Q767* [cytosol] (R-HSA-9666946) APC E941* [cytosol] (R-HSA-9666947) APC Q1303* [cytosol] (R-HSA-9666972) APC S943* [cytosol] (R-HSA-9666973) APC E1306* [cytosol] (R-HSA-9666975) APC S895* [cytosol] (R-HSA-9666969) APC S1315* [cytosol] (R-HSA-9666970) APC G1412* [cytosol] (R-HSA-9666971) APC Y1376* [cytosol] (R-HSA-9666964) APC Q886* [cytosol] (R-HSA-9666965) APC S1392* [cytosol] (R-HSA-9666966) APC S1539* [cytosol] (R-HSA-9666967) APC E1451* [cytosol] (R-HSA-9666960) APC E1397* [cytosol] (R-HSA-9666961) APC Q1406* [cytosol] (R-HSA-9666962) APC E1544* [cytosol] (R-HSA-9666963) APC F1197* [cytosol] (R-HSA-5246655) APC Q1338* [cytosol] (R-HSA-5246654) APC S811* [cytosol] (R-HSA-5246652) APC I1417 fs2 [cytosol] (R-HSA-5246651) APC E1554 [cytosol] (R-HSA-5246648) APC(1-777) [cytosol] (R-HSA-2976014) APC(778-2843) [cytosol] (R-HSA-2976013) APC [cytosol] (R-HSA-2976015) p-ub-APC [cytosol] (R-HSA-3009421) K63polyUb-APC [cytosol] (R-HSA-5246690) APC [nucleoplasm] (R-HSA-3361755)	0.667	4
UniProt:O75554 WBP4	1	WBP4 [nucleoplasm] (R-HSA-8867895)	0.667	5
UniProt:O95365 ZBT7A			0.649	9
UniProt:P07948 LYN	5	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y396-LYN [plasma membrane] (R-HSA-2454229) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943)	0.609	2
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.573	3
UniProt:O60861 GAS7			0.564	2
UniProt:Q12805 EFEMP1	1	EFEMP1 [extracellular region] (R-HSA-2161393)	0.553	2
UniProt:P38159 RBMX	1	RBMX [nucleoplasm] (R-HSA-71939)	0.553	2
UniProt:O75525 KHDRBS3	2	p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035) KHDRSB3 [nucleoplasm] (R-HSA-8849040)	0.553	2
UniProt:Q8N3X1 FNBP4			0.544	4
UniProt:P51531 SMARCA2	1	SMARCA2 [nucleoplasm] (R-HSA-389256)	0.524	2
UniProt:P15498 VAV1	5	p-Y174-VAV1 [cytosol] (R-HSA-437946) VAV1 [plasma membrane] (R-HSA-1045153) VAV1 [cytosol] (R-HSA-195066) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323) p-Y-VAV1 [cytosol] (R-HSA-9029087)	0.524	3
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.462	4

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