Reactome | KHDRBS1 [nucleoplasm]

KHDRBS1 [nucleoplasm]

Stable Identifier

R-HSA-8848941

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

KH domain-containing, RNA-binding, signal transduction-associated protein 1, SAM68, Src-associated in mitosis 68 kDa protein, GAP-associated tyrosine phosphoprotein p62, p21 Ras GTPase-activating protein-associated p62

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q07666 KHDRBS1

Gene Names

KHDRBS1, SAM68

Chain

chain:1-443

Reference Genes

BioGPS Gene:10657 KHDRBS1

COSMIC (genes):KHDRBS1 KHDRBS1

CTD Gene:10657 KHDRBS1

dbSNP Gene:10657 KHDRBS1

ENSEMBL:ENSG00000121774 KHDRBS1

ENSEMBL:ENSG00000121774.18 KHDRBS1

HGNC:18116 KHDRBS1

KEGG Gene (Homo sapiens):10657 KHDRBS1

Monarch:10657 KHDRBS1

NCBI Gene:10657 KHDRBS1

OMIM:602489 KHDRBS1

UCSC:Q07666 KHDRBS1

Reference Transcript

Other Identifiers

10657

11715937_a_at

11715938_x_at

11715939_a_at

11715940_s_at

11748491_a_at

16655003

16655005

16655007

16655009

16655011

16661917

18670571

18670572

18670573

18670574

18670575

18670576

18670577

18670579

18670580

18670581

18670582

18670583

200040_PM_at

200040_at

201488_PM_x_at

201488_x_at

2328473

2328474

2328475

2328476

2328477

2328484

2328486

2328487

2328488

2328489

2328494

2328496

2328499

2328500

2328501

2328502

2328503

2328504

2328505

2328506

2328507

39346_at

7892901

7893709

7894115

7894518

7894790

7894951

7895003

7895241

7895411

7895710

7895932

7895943

7896005

7896200

7896331

7896358

7899654

A_23_P149012

A_23_P200386

GE58125

GO:0000082

GO:0000086

GO:0000122

GO:0000278

GO:0000381

GO:0002376

GO:0003676

GO:0003677

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006397

GO:0006913

GO:0007049

GO:0007166

GO:0007283

GO:0008143

GO:0008266

GO:0016020

GO:0016071

GO:0017124

GO:0019904

GO:0022414

GO:0023052

GO:0032991

GO:0035591

GO:0042169

GO:0042802

GO:0043226

GO:0044877

GO:0045892

GO:0045948

GO:0046831

GO:0046833

GO:0048024

GO:0050852

GO:0060090

GO:0070618

GO:1990782

HMNXSV003027870

HMNXSV003050297

ILMN_2076640

M88108_at

PH_hs_0006592

TC01000417.hg

g12653852_3p_a_at

g12653852_3p_x_at

g5730026_3p_at

Participates

as an input of

PTK6 binds KHDRBS1 (Homo sapiens)

as a component of

p-Y342-PTK6:KHDRBS1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]

p-Y435,Y440,Y443-KHDRBS1 [cytosol]

Inferred To

KHDRBS1 [nucleoplasm] (Bos taurus)

KHDRBS1 [nucleoplasm] (Sus scrofa)

khdrbs1l [nucleoplasm] (Danio rerio)

Khdrbs1 [nucleoplasm] (Mus musculus)

Khdrbs1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001258807.1, NP_006550.1

OpenTargets

ENSG00000121774

GeneCards

Q07666

HPA

ENSG00000121774-KHDRBS1

Ensembl

ENSP00000417731, ENSP00000313829, ENST00000327300, ENST00000492989, ENSG00000121774

PRO

Q07666

Pharos - Targets

Q07666

PDB

7Z9A, 7ZAM, 2XA6, 7Z89, 3QHE, 7ZAB

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.868	8
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.848	8
UniProt:P09651 HNRNPA1	2	HNRNPA1 [cytosol] (R-HSA-9727902) HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.839	9
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.835	5
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.78	4
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.756	4
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.692	3
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.668	3
UniProt:O75554 WBP4	1	WBP4 [nucleoplasm] (R-HSA-8867895)	0.667	5
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.667	4
UniProt:O95365 ZBT7A			0.649	9
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875)	0.609	2
UniProt:P12931 SRC	6	SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.573	3
UniProt:O60861 GAS7			0.564	2
UniProt:P38159 RBMX	2	RBMX [cytosol] (R-HSA-9715135) RBMX [nucleoplasm] (R-HSA-71939)	0.553	2
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.553	2
UniProt:Q12805 EFEMP1	1	EFEMP1 [extracellular region] (R-HSA-2161393)	0.553	2
UniProt:Q9NRI5 DISC1			0.547	2
UniProt:Q8N3X1 FNBP4			0.544	4
UniProt:P51531 SMARCA2	1	SMARCA2 [nucleoplasm] (R-HSA-389256)	0.524	2
UniProt:P15498 VAV1	5	p-Y-VAV1 [cytosol] (R-HSA-9029087) VAV1 [plasma membrane] (R-HSA-1045153) VAV1 [cytosol] (R-HSA-195066) p-Y174-VAV1 [cytosol] (R-HSA-437946) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323)	0.524	3

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