PTK6 phosphorylates KHDRBS1

Stable Identifier
R-HSA-8848975
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PTK6 phosphorylates KHDRBS1 (SAM68) on tyrosine residues Y435, Y440 and Y443, located within the nuclear localization signal (NLS) of KHDRBS1 (Lukong et al. 2005). PTK6-mediated phosphorylation inhibits the interaction of KHDRBS1 with RNA (Derry et al. 2000, Coyle et al. 2003).

Literature References
PubMed ID Title Journal Year
16179349 Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression

Lukong, KE, Larocque, D, Tyner, AL, Richard, S

J. Biol. Chem. 2005
10913193 Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

Derry, JJ, Richard, S, Valderrama Carvajal, H, Ye, X, Vasioukhin, V, Cochrane, AW, Chen, T, Tyner, AL

Mol. Cell. Biol. 2000
12482964 Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK

Coyle, JH, Guzik, BW, Bor, YC, Jin, L, Eisner-Smerage, L, Taylor, SJ, Rekosh, D, Hammarskjold, ML

Mol. Cell. Biol. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-Y342-PTK6:KHDRBS1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed