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p-Y435,Y440,Y443-KHDRBS1 [cytosol]
Stable Identifier
R-HSA-8848995
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y435,Y440,Y443-SAM68
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates Proteins Involved in RNA Processing (Homo sapiens)
Phosphorylated KHDRBS1 translocates to the cytosol (Homo sapiens)
p-Y435,Y440,Y443-KHDRBS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q07666 KHDRBS1
Gene Names
KHDRBS1, SAM68
Chain
chain:1-443
Reference Genes
BioGPS Gene:10657 KHDRBS1
COSMIC (genes):KHDRBS1 KHDRBS1
CTD Gene:10657 KHDRBS1
dbSNP Gene:10657 KHDRBS1
ENSEMBL:ENSG00000121774 KHDRBS1
ENSEMBL_homo_sapiens_GENE:ENSG00000121774.18 KHDRBS1
HGNC:18116 KHDRBS1
KEGG Gene (Homo sapiens):10657 KHDRBS1
Monarch:10657 KHDRBS1
NCBI Gene:10657 KHDRBS1
OMIM:602489 KHDRBS1
UCSC:Q07666 KHDRBS1
Reference Transcript
RefSeq:NM_001271878.1 KHDRBS1
RefSeq:NM_006559.2 KHDRBS1
Other Identifiers
10657
11715937_a_at
11715938_x_at
11715939_a_at
11715940_s_at
11748491_a_at
16655003
16655005
16655007
16655009
16655011
16661917
18670571
18670572
18670573
18670574
18670575
18670576
18670577
18670579
18670580
18670581
18670582
18670583
200040_PM_at
200040_at
201488_PM_x_at
201488_x_at
2328473
2328474
2328475
2328476
2328477
2328484
2328486
2328487
2328488
2328489
2328494
2328496
2328499
2328500
2328501
2328502
2328503
2328504
2328505
2328506
2328507
39346_at
7892901
7893709
7894115
7894518
7894790
7894951
7895003
7895241
7895411
7895710
7895932
7895943
7896005
7896200
7896331
7896358
7899654
A_23_P149012
A_23_P200386
GE58125
GO:0000082
GO:0000086
GO:0000122
GO:0000278
GO:0000381
GO:0002376
GO:0003676
GO:0003677
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006397
GO:0006913
GO:0007049
GO:0007166
GO:0007283
GO:0008143
GO:0008266
GO:0016020
GO:0016071
GO:0017124
GO:0019904
GO:0022414
GO:0023052
GO:0032991
GO:0035591
GO:0042169
GO:0042802
GO:0043226
GO:0044877
GO:0045892
GO:0045948
GO:0046831
GO:0046833
GO:0048024
GO:0050852
GO:0060090
GO:0070618
GO:1990782
HMNXSV003027870
HMNXSV003050297
ILMN_2076640
M88108_at
PH_hs_0006592
TC01000417.hg
g12653852_3p_a_at
g12653852_3p_x_at
g5730026_3p_at
Participates
as an output of
Phosphorylated KHDRBS1 translocates to the cytosol (Homo sapiens)
Other forms of this molecule
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
KHDRBS1 [nucleoplasm]
Inferred To
phospho-Dmel\CG4021 [cytosol]
(Drosophila melanogaster)
phospho-qkr58E-2 [cytosol]
(Drosophila melanogaster)
phospho-qkr58E-3 [cytosol]
(Drosophila melanogaster)
phospho-cg10384 [cytosol]
(Drosophila melanogaster)
phospho-KHDRBS1 [cytosol]
(Bos taurus)
phospho-KHDRBS1 [cytosol]
(Canis familiaris)
phospho-KHDRBS1 [cytosol]
(Sus scrofa)
phospho-qkr54B [cytosol]
(Drosophila melanogaster)
phospho-cg3927 [cytosol]
(Drosophila melanogaster)
phospho-khdrbs1b [cytosol]
(Danio rerio)
phospho-qkr58E-1 [cytosol]
(Drosophila melanogaster)
Homologues of p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(Drosophila melanogaster)
phospho-nsr [cytosol]
(Drosophila melanogaster)
phospho-p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(Gallus gallus)
phospho-Khdrbs1 [cytosol]
(Mus musculus)
phospho-Khdrbs1 [cytosol]
(Rattus norvegicus)
phospho-khdrbs1 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 435
Coordinate
435
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 440
Coordinate
440
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 443
Coordinate
443
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001258807.1
,
NP_006550.1
OpenTargets
ENSG00000121774
GeneCards
Q07666
HPA
ENSG00000121774-KHDRBS1
Ensembl
ENSG00000121774
,
ENST00000492989
,
ENSP00000313829
,
ENST00000327300
,
ENSP00000417731
PRO
Q07666
Pharos - Targets
Q07666
PDB
2XA6
,
7ZAB
,
3QHE
,
7Z89
,
7ZAM
,
7Z9A
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09651 HNRNPA1
2
HNRNPA1 [cytosol]
(R-HSA-9727902)
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
0.875
10
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.868
8
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.848
8
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.835
5
UniProt:P08631 HCK
2
p-HCK [cytosol]
(R-HSA-9676060)
HCK [cytosol]
(R-HSA-167708)
0.78
4
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.756
4
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.692
3
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.668
3
UniProt:P38159 RBMX
2
RBMX [cytosol]
(R-HSA-9715135)
RBMX [nucleoplasm]
(R-HSA-71939)
0.667
3
UniProt:P25054 APC
20
APC R213* [cytosol]
(R-HSA-9666924)
APC C1410* [cytosol]
(R-HSA-9666925)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
0.667
4
UniProt:O75554 WBP4
1
WBP4 [nucleoplasm]
(R-HSA-8867895)
0.667
5
UniProt:O75525 KHDRBS3
2
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
0.667
3
UniProt:O95365 ZBT7A
0.649
9
UniProt:P07948 LYN
7
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
LYN [plasma membrane]
(R-HSA-197943)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
p-Y397-LYN [plasma membrane]
(R-HSA-2454229)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
LYN [cytosol]
(R-HSA-354251)
0.609
2
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.573
3
UniProt:O60861 GAS7
0.564
2
UniProt:Q12805 EFEMP1
1
EFEMP1 [extracellular region]
(R-HSA-2161393)
0.553
2
UniProt:Q9NRI5 DISC1
0.547
2
UniProt:Q08211 DHX9
3
DHX9 [nucleoplasm]
(R-HSA-53517)
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
0.547
2
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.547
3
UniProt:Q8N3X1 FNBP4
0.544
4
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.527
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
5
UniProt:P51531 SMARCA2
1
SMARCA2 [nucleoplasm]
(R-HSA-389256)
0.524
2
UniProt:P15498 VAV1
5
p-Y-VAV1 [cytosol]
(R-HSA-9029087)
VAV1 [plasma membrane]
(R-HSA-1045153)
VAV1 [cytosol]
(R-HSA-195066)
p-Y174-VAV1 [cytosol]
(R-HSA-437946)
p-Y142,Y160,Y174-VAV1 [plasma membrane]
(R-HSA-389323)
0.524
3
UniProt:Q16630 CPSF6
2
CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838987)
CPSF6(1-490)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1614368)
0.483
2
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.483
2
UniProt:P07910 HNRNPC
3
HNRNPC [cytosol]
(R-HSA-9715136)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [nucleoplasm]
(R-HSA-71933)
0.483
2
UniProt:Q12906 ILF3
3
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
ILF3 [cytosol]
(R-HSA-450564)
ILF3 [nucleoplasm]
(R-HSA-9760401)
0.483
2
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