ARHGAP35 binds RASA1

Stable Identifier
R-HSA-8849094
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PTK6 (BRK) mediated phosphorylation of ARHGAP35 (p190 Rho GAP) promotes binding of ARHGAP35 to RASA1 (p120 RAS GAP). Binding to ARHGAP35 inhibits RASA1-mediated stimulation of RAS GTPase activity, resulting in prolonged RAS signaling (Shen et al. 2008).

Literature References
PubMed ID Title Journal Year
18829532 Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

Shen, CH, Chen, HY, Lin, MS, Li, FY, Chang, CC, Kuo, ML, Settleman, J, Chen, RH

Cancer Res. 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created