Reactome | DDX39B [nucleoplasm]

DDX39B [nucleoplasm]

Stable Identifier

R-HSA-8849139

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Spliceosome RNA helicase DDX39B ecNumber3.6.4.13/ecNumber, DX39B_HUMAN, UAP56

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        DDX39B:ATP [nucleoplasm] (Homo sapiens)
        
        DDX39A,B [nucleoplasm] (Homo sapiens)
        
        DDX39B [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        DDX39B:ATP [nucleoplasm] (Homo sapiens)
        
        DDX39A,B [nucleoplasm] (Homo sapiens)
        
        DDX39B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13838 DDX39B

Gene Names

DDX39B, BAT1, UAP56

Chain

initiator methionine:1, chain:2-428

Reference Genes

BioGPS Gene:7919 DDX39B

COSMIC (genes):DDX39B DDX39B

CTD Gene:7919 DDX39B

dbSNP Gene:7919 DDX39B

ENSEMBL:ENSG00000198563 DDX39B

ENSEMBL:ENSG00000215425 DDX39B

ENSEMBL:ENSG00000225073 DDX39B

ENSEMBL:ENSG00000225859 DDX39B

ENSEMBL:ENSG00000229496 DDX39B

ENSEMBL:ENSG00000230624 DDX39B

ENSEMBL:ENSG00000235439 DDX39B

HGNC:13917 DDX39B

KEGG Gene (Homo sapiens):7919 DDX39B

Monarch:7919 DDX39B

NCBI Gene:7919 DDX39B

OMIM:142560 DDX39B

UCSC:Q13838 DDX39B

Reference Transcript

Other Identifiers

0004120433

0006020441

0006290494

11715525_a_at

11715527_x_at

11715528_a_at

11715529_x_at

11736015_a_at

17026742

17031799

17031849

17031855

17031857

17031860

17034271

17034321

17034327

17034329

17034332

17036519

17036569

17036575

17036577

17036580

17039314

17039362

17039368

17039370

17039373

18670465

18670467

18670468

18670469

18670470

18670471

18670474

18670480

18670485

18670486

18670487

18670496

18670497

18670498

18670499

18670507

18670508

18670509

18670510

200041_PM_s_at

200041_s_at

2949039

2949042

2949043

2949045

2949047

2949051

2949058

2949065

2949067

2949068

2949075

2949076

2949084

2949085

2949086

2949087

3394578

35292_at

72981_at

7892648

7893002

7894604

7894984

7895014

7895226

7895616

7895919

7896287

7896458

7919

8124926

8178476

8178508

8179750

A_24_P904903

GE79374

GO:0000166

GO:0000245

GO:0000346

GO:0000398

GO:0001889

GO:0003674

GO:0003676

GO:0003723

GO:0003724

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005681

GO:0005687

GO:0005688

GO:0005737

GO:0006259

GO:0006397

GO:0006405

GO:0006406

GO:0006412

GO:0006810

GO:0006913

GO:0006950

GO:0007049

GO:0008150

GO:0008186

GO:0008283

GO:0008380

GO:0009058

GO:0010501

GO:0015031

GO:0016363

GO:0016607

GO:0016787

GO:0016887

GO:0017070

GO:0022607

GO:0022618

GO:0030154

GO:0030621

GO:0031124

GO:0032786

GO:0032991

GO:0034641

GO:0040007

GO:0042802

GO:0043008

GO:0043167

GO:0043226

GO:0044403

GO:0044877

GO:0045727

GO:0046784

GO:0048856

GO:0051028

GO:0061051

GO:0065003

GO:1904707

GO:2000002

GO:2000573

ILMN_1674778

ILMN_1686626

ILMN_1690576

ILMN_2357976

TC06003590.hg

Z37166_at

g4758111_3p_a_at

Participant Of

hasMember

DDX39A,B [nucleoplasm]

Inferred To

nadsyn1 [nucleoplasm] (Xenopus tropicalis)

Ddx39b [nucleoplasm] (Mus musculus)

Ddx39b [nucleoplasm] (Rattus norvegicus)

Hel25E [nucleoplasm] (Drosophila melanogaster)

DDX39B [nucleoplasm] (Canis familiaris)

ddx39b [nucleoplasm] (Danio rerio)

hel-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_004631.1, NP_542165.1

Target Pathogen

5b354852be737e166372e89a

OpenTargets

ENSG00000198563

GeneCards

Q13838

HPA

ENSG00000198563-DDX39B

Ensembl

ENSP00000398775, ENSP00000411853, ENST00000412330, ENST00000456666, ENSP00000393712, ENSP00000373000, ENST00000430784, ENSP00000394160, ENSP00000383151, ENSP00000399030, ENSP00000390999, ENST00000456476, ENSP00000400326, ENSP00000383152, ENST00000445218, ENSG00000225859, ENSP00000407419, ENST00000441425, ENSG00000198563, ENSG00000215425, ENST00000414440, ENSP00000387994, ENSP00000388880, ENST00000383508, ENSP00000404695, ENSP00000379475, ENST00000396172, ENSP00000405560, ENSP00000411136, ENST00000400295, ENST00000453138, ENSP00000416269, ENST00000458640, ENST00000400296, ENST00000431360, ENSP00000391463, ENSG00000225073, ENSG00000230624, ENST00000448296, ENSG00000229496, ENST00000412106, ENST00000413678, ENST00000416863, ENST00000415689, ENSG00000235439

PRO

Q13838

HMDB Protein

HMDBP10642

PDB

1XTI, 1XTK, 1T5I, 1T6N, 1XTJ

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3Y2 CHTOP	1	CHTOP [nucleoplasm] (R-HSA-8849147)	0.782	7
UniProt:Q86V81 ALYREF	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.702	4
UniProt:P82979 SARNP	1	SARNP [nucleoplasm] (R-HSA-8849146)	0.666	4
UniProt:O00560 SDCBP	3	SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.462	2

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