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EIF4A3 [nucleoplasm]
Stable Identifier
R-HSA-8849149
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Eukaryotic initiation factor 4A-III, IF4A3_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P84103 SRSF3
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
EIF4A3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P38919 EIF4A3
Gene Names
EIF4A3, DDX48, KIAA0111
Chain
chain:1-411, initiator methionine:, chain:2-411
Reference Genes
BioGPS Gene:9775 EIF4A3
COSMIC (genes):EIF4A3 EIF4A3
CTD Gene:9775 EIF4A3
dbSNP Gene:9775 EIF4A3
ENSEMBL:ENSG00000141543 EIF4A3
ENSEMBL_homo_sapiens_GENE:ENSG00000141543.12 EIF4A3
ENSEMBL_homo_sapiens_GENE:ENSG00000291508.1 EIF4A3
HGNC:18683 EIF4A3
KEGG Gene (Homo sapiens):9775 EIF4A3
Monarch:9775 EIF4A3
NCBI Gene:9775 EIF4A3
OMIM:608546 EIF4A3
UCSC:P38919 EIF4A3
Reference Transcript
RefSeq:NM_014740.3 EIF4A3
Other Identifiers
11756176_a_at
16849667
201303_PM_at
201303_at
3773311
3773313
3773314
3773316
3773318
3773321
3773324
3773326
3773327
3773328
3773329
3773332
3773334
3773335
3773336
3773337
3773338
3773339
38031_at
8019046
9775
A_23_P141636
D21853_at
GE57117
GO:0000166
GO:0000184
GO:0000398
GO:0003676
GO:0003723
GO:0003724
GO:0003729
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005681
GO:0005730
GO:0005737
GO:0005829
GO:0006364
GO:0006397
GO:0006406
GO:0006417
GO:0006913
GO:0008143
GO:0008306
GO:0008380
GO:0010629
GO:0014070
GO:0016020
GO:0016071
GO:0016607
GO:0016787
GO:0016887
GO:0017148
GO:0023052
GO:0030425
GO:0035145
GO:0035368
GO:0035613
GO:0035640
GO:0042254
GO:0043021
GO:0043025
GO:0043226
GO:0045727
GO:0048701
GO:0048856
GO:0050877
GO:0051028
GO:0071006
GO:0071013
GO:0072715
GO:0090394
GO:0098794
GO:0098978
GO:0099578
GO:0140098
GO:0140657
GO:1904570
GO:1990416
GO:1990904
GO:2000622
HMNXSV003023654
ILMN_1667043
PH_hs_0024508
TC17001933.hg
g7661919_3p_at
Participates
as a component of
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
Core EJC [nucleoplasm] (Homo sapiens)
as an input of
Formation of the Spliceosomal Bact complex (Homo sapiens)
Other forms of this molecule
EIF4A3 [cytosol]
Inferred To
EIF4A3 [nucleoplasm]
(Bos taurus)
EIF4A3 [nucleoplasm]
(Canis familiaris)
EIF4A3 [nucleoplasm]
(Danio rerio)
EIF4A3 [nucleoplasm]
(Dictyostelium discoideum)
EIF4A3 [nucleoplasm]
(Drosophila melanogaster)
EIF4A3 [nucleoplasm]
(Gallus gallus)
EIF4A3 [nucleoplasm]
(Mus musculus)
EIF4A3 [nucleoplasm]
(Plasmodium falciparum)
EIF4A3 [nucleoplasm]
(Rattus norvegicus)
EIF4A3 [nucleoplasm]
(Saccharomyces cerevisiae)
EIF4A3 [nucleoplasm]
(Schizosaccharomyces pombe)
EIF4A3 [nucleoplasm]
(Sus scrofa)
EIF4A3 [nucleoplasm]
(Xenopus tropicalis)
eif-4a3 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_055555.1
OpenTargets
ENSG00000141543
GeneCards
P38919
HPA
ENSG00000141543-EIF4A3
Ensembl
ENST00000647795
,
ENSP00000497641
,
ENST00000649764
,
ENSP00000497661
,
ENSG00000141543
PRO
P38919
Pharos - Targets
P38919
Orphanet
22596
HMDB Protein
HMDBP11795
PDB
7W5A
,
7ZNJ
,
3EX7
,
5XJC
,
6ICZ
,
7W5B
,
5YZG
,
2XB2
,
2J0U
,
8C6J
,
2HXY
,
2J0S
,
6YVH
,
7W59
,
2J0Q
,
7A5P
,
2HYI
,
4C9B
,
5MQF
,
6QDV
Interactors (62)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15234 CASC3
2
CASC3 [cytosol]
(R-HSA-927807)
CASC3 [nucleoplasm]
(R-HSA-8849148)
0.98
37
UniProt:Q9Y5S9 RBM8A
2
RBM8A [cytosol]
(R-HSA-162462)
RBM8A [nucleoplasm]
(R-HSA-156659)
0.947
22
UniProt:P61326 MAGOH
1
MAGOH [nucleoplasm]
(R-HSA-156658)
0.938
30
UniProt:Q9BZI7 UPF3B
2
UPF3B [nucleoplasm]
(R-HSA-156776)
UPF3B [cytosol]
(R-HSA-159258)
0.883
9
UniProt:Q9HCG8 CWC22
1
CWC22 [nucleoplasm]
(R-HSA-8865956)
0.815
6
UniProt:Q6PII3 CC174
0.743
5
UniProt:Q92900-2 UPF1
0.725
4
UniProt:Q53EL6 PDCD4
1
PDCD4 [cytosol]
(R-HSA-5432887)
0.718
6
UniProt:Q96Q15 SMG1
1
SMG1 [cytosol]
(R-HSA-927760)
0.69
4
UniProt:Q5C9Z4 NOM1
0.688
4
UniProt:Q07955 SRSF1
1
SRSF1 [nucleoplasm]
(R-HSA-72031)
0.662
7
UniProt:Q9Y5S9-1 RBM8A
0.643
6
UniProt:Q9H307 PNN
1
PNN [nucleoplasm]
(R-HSA-9770779)
0.643
3
UniProt:P09651 HNRNPA1
2
HNRNPA1 [cytosol]
(R-HSA-9727902)
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
0.643
3
UniProt:Q9BY77 POLDIP3
2
POLDIP3 [nucleoplasm]
(R-HSA-8850646)
POLDIP3 [cytosol]
(R-HSA-8850627)
0.623
3
UniProt:Q86V81 ALYREF
2
ALYREF [nucleoplasm]
(R-HSA-156649)
ALYREF [cytosol]
(R-HSA-158482)
0.597
3
UniProt:P84103 SRSF3
1
SRSF3 [nucleoplasm]
(R-HSA-72035)
0.597
3
UniProt:Q9Y2W1 THRAP3
1
THRAP3 [nucleoplasm]
(R-HSA-8932115)
0.564
2
UniProt:Q15287 RNPS1
2
RNPS1 [nucleoplasm]
(R-HSA-156778)
RNPS1 [cytosol]
(R-HSA-159256)
0.558
4
UniProt:Q96GN5 CDA7L
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:Q9H257-2 CARD9
0.556
3
UniProt:Q9H8Y1 VRTN
0.556
3
UniProt:Q9NRI5-2 DISC1
0.556
3
UniProt:P25786 PSMA1
2
PSMA1 [nucleoplasm]
(R-HSA-174333)
PSMA1 [cytosol]
(R-HSA-68724)
0.556
3
UniProt:Q6P9H4 CNKR3
0.556
3
UniProt:P62487 POLR2G
1
POLR2G [nucleoplasm]
(R-HSA-63517)
0.556
3
UniProt:Q3KNR5 Q3KNR5
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:Q9NY93 DDX56
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q96KQ7 EHMT2
1
EHMT2 [nucleoplasm]
(R-HSA-212151)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:P98169 ZXDB
0.556
3
UniProt:P50221 MEOX1
0.556
3
UniProt:P55039 DRG2
2
3OHK21-DRG2 [cytosol]
(R-HSA-9629595)
DRG2 [cytosol]
(R-HSA-9629597)
0.556
3
UniProt:Q9GZT8 NIF3L
0.556
3
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
PRMT5 [cytosol]
(R-HSA-191876)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.536
2
UniProt:O60306 AQR
1
AQR [nucleoplasm]
(R-HSA-6781960)
0.528
2
UniProt:Q9Y3X0 CCDC9
0.527
2
UniProt:P60842 EIF4A1
1
EIF4A1 [cytosol]
(R-HSA-72573)
0.527
2
UniProt:O75533 SF3B1
1
SF3B1 [nucleoplasm]
(R-HSA-71968)
0.527
2
UniProt:Q8N653 LZTR1
0.527
2
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.527
2
UniProt:Q99459 CDC5L
1
CDC5L [nucleoplasm]
(R-HSA-5420887)
0.527
2
UniProt:Q15459 SF3A1
1
SF3A1 [nucleoplasm]
(R-HSA-71962)
0.527
2
UniProt:Q8TAD8 SNIP1
1
SNIP1 [nucleoplasm]
(R-HSA-3222315)
0.527
2
UniProt:Q53F19 NCBP3
0.527
4
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.527
6
UniProt:P14678 SNRPB
4
SNRPB [nucleoplasm]
(R-HSA-71896)
Me2-R108,R112-SNRPB [nucleoplasm]
(R-HSA-192213)
SNRPB [cytosol]
(R-HSA-191798)
2xMe-SNRPB [cytosol]
(R-HSA-192218)
0.527
2
UniProt:P52298 NCBP2
2
NCBP2 [nucleoplasm]
(R-HSA-51463)
NCBP2 [cytosol]
(R-HSA-162458)
0.527
5
UniProt:Q13523 PRPF4B
1
PRPF4B [nucleoplasm]
(R-HSA-9769525)
0.527
2
UniProt:Q14498 RBM39
1
RBM39 [nucleoplasm]
(R-HSA-9770254)
0.527
2
UniProt:P07910 HNRNPC
3
HNRNPC [cytosol]
(R-HSA-9715136)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [nucleoplasm]
(R-HSA-71933)
0.527
2
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.527
2
UniProt:Q16629 SRSF7
1
SRSF7 [nucleoplasm]
(R-HSA-72029)
0.527
2
UniProt:O00422 SAP18
1
SAP18 [nucleoplasm]
(R-HSA-351694)
0.499
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
5
UniProt:Q13838 DDX39B
2
DDX39B [cytosol]
(R-HSA-9715154)
DDX39B [nucleoplasm]
(R-HSA-8849139)
0.462
2
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