Reactome: A Curated Pathway Database

LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine

Stable Identifier
R-HSA-8849345
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

AGPAT3 is an acyltransferase that can act on lysophosphatidylcholine to generate phosphatidylcholine (Prasad et al, 2011; Echard at al, 1998). This activity may counter the membrane tubule-inducing activity of Golgi PLA2 enzymes, thus favouring COPI-dependent vesicle formation over COPI-indendent retrograde traffic. While many lysophospholipid acyltransferases are ER-localized, AGPAT3 has been shown to also be present at the Golgi membrane, making it well situated to counter PLA2 activity during membrane tubule formation (Drecktah et al, 2003; Schmidt et al, 2009; reviewed in Ha et al, 2012; Heffernan and Simpson, 2014).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
1-acylglycerol-3-phosphate O-acyltransferase activity of AGPAT3 [Golgi membrane] AGPAT3 [Golgi membrane] 1-acylglycerol-3-phosphate O-acyltransferase activity (0003841)
Orthologous Events