LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine

Stable Identifier
R-HSA-8849345
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AGPAT3 is an acyltransferase that can act on lysophosphatidylcholine to generate phosphatidylcholine (Prasad et al, 2011; Echard at al, 1998). This activity may counter the membrane tubule-inducing activity of Golgi PLA2 enzymes, thus favouring COPI-dependent vesicle formation over COPI-indendent retrograde traffic. While many lysophospholipid acyltransferases are ER-localized, AGPAT3 has been shown to also be present at the Golgi membrane, making it well situated to counter PLA2 activity during membrane tubule formation (Drecktah et al, 2003; Schmidt et al, 2009; reviewed in Ha et al, 2012; Heffernan and Simpson, 2014).

Literature References
PubMed ID Title Journal Year
22562055 Regulation of the Golgi complex by phospholipid remodeling enzymes

Ha, KD, Clarke, BA, Brown, WJ

Biochim. Biophys. Acta 2012
21173190 Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria

Prasad, SS, Garg, A, Agarwal, AK

J Lipid Res 2011
12925777 Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking

Drecktrah, D, Chambers, K, Racoosin, EL, Cluett, EB, Gucwa, A, Jackson, B, Brown, WJ

Mol. Biol. Cell 2003
25233431 The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport

Heffernan, LF, Simpson, JC

Biochem. Soc. Trans. 2014
19635840 Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function

Schmidt, JA, Brown, WJ

J. Cell Biol. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
1-acylglycerol-3-phosphate O-acyltransferase activity of AGPAT3 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created