RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex

Stable Identifier
R-HSA-8849350
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Retrograde tubule formation may depend on the minus-end directed dynein-dynactin motor complex, which is recruited to the Golgi through interaction with both RAB6 and BICD (Short et al, 2002; Hoogenraad et al, 2001; Matanis et al, 2002; Young et al, 2005; Januschke et al, 2007). Interaction of dynein:dynactin with RAB6:GTP activates the motor protein by displacing the PAFAH1B1 protein, which otherwise keeps the motor "idling" (Yamada et al, 2013; reviewed in Heffernan and Simpson, 2014).

Participants
Participant Of
Orthologous Events