RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex

Stable Identifier
R-HSA-8849350
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Retrograde tubule formation may depend on the minus-end directed dynein-dynactin motor complex, which is recruited to the Golgi through interaction with both RAB6 and BICD (Short et al, 2002; Hoogenraad et al, 2001; Matanis et al, 2002; Young et al, 2005; Januschke et al, 2007). Interaction of dynein:dynactin with RAB6:GTP activates the motor protein by displacing the PAFAH1B1 protein, which otherwise keeps the motor "idling" (Yamada et al, 2013; reviewed in Heffernan and Simpson, 2014).

Literature References
PubMed ID Title Journal Year
12447383 Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex

Matanis, T, Akhmanova, A, Wulf, P, del Nery, E, Weide, T, Stepanova, T, Galjart, N, Grosveld, F, Goud, B, De Zeeuw, CI, Barnekow, A, Hoogenraad, CC

Nat. Cell Biol. 2002
15483056 Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A'

Young, J, Stauber, T, del Nery, E, Vernos, I, Pepperkok, R, Nilsson, T

Mol. Biol. Cell 2005
11483508 Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes

Hoogenraad, CC, Akhmanova, A, Howell, SA, Dortland, BR, De Zeeuw, CI, Willemsen, R, Visser, P, Grosveld, F, Galjart, N

EMBO J. 2001
23783758 Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement

Yamada, M, Kumamoto, K, Mikuni, S, Arai, Y, Kinjo, M, Nagai, T, Tsukasaki, Y, Watanabe, TM, Fukui, M, Jin, M, Toba, S, Hirotsune, S

Nat Commun 2013
12401177 The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes

Short, B, Preisinger, C, Schaletzky, J, Kopajtich, R, Barr, FA

Curr. Biol. 2002
17827179 Rab6 and the secretory pathway affect oocyte polarity in Drosophila

Januschke, J, Nicolas, E, Compagnon, J, Formstecher, E, Goud, B, Guichet, A

Development 2007
25233431 The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport

Heffernan, LF, Simpson, JC

Biochem. Soc. Trans. 2014
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