Dynein drives COPI-independent retrograde traffic from the Golgi to the ER

Stable Identifier
R-HSA-8849353
Type
Reaction [omitted]
Species
Homo sapiens
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The RAB6 pathway moves select retrograde cargo from the Golgi to the ER in a motor-dependent manner, although the precise details of this translocation remain to be worked out (Girod et al, 1999; White et al, 1999; reviewed in Heffernan and Simpson, 2014). Active RAB18 at the ER membrane may contribute to targeting and fusion of COPI-independent retrograde carriers through interaction with ER-localized tethering factors (Dejgaard et al, 2008; Gerondopoulos et al, 2014; Gillingham et al, 2014)

Literature References
PubMed ID Title Journal Year
18664496 Rab18 and Rab43 have key roles in ER-Golgi trafficking

Dejgaard, SY, Murshid, A, Erman, A, Kizilay, O, Verbich, D, Lodge, R, Dejgaard, K, Ly-Hartig, TB, Pepperkok, R, Simpson, JC, Presley, JF

J. Cell. Sci. 2008
24891604 Rab18 and a Rab18 GEF complex are required for normal ER structure

Gerondopoulos, A, Bastos, RN, Yoshimura, S, Anderson, R, Carpanini, S, Aligianis, I, Handley, MT, Barr, FA

J. Cell Biol. 2014
10562278 Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells

White, J, Johannes, L, Mallard, F, Girod, A, Grill, S, Reinsch, S, Keller, P, Tzschaschel, B, Echard, A, Goud, B, Stelzer, EH

J. Cell Biol. 1999
25453831 Toward a comprehensive map of the effectors of rab GTPases

Gillingham, AK, Sinka, R, Torres, IL, Lilley, KS, Munro, S

Dev. Cell 2014
25233431 The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport

Heffernan, LF, Simpson, JC

Biochem. Soc. Trans. 2014
10559986 Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum

Girod, A, Storrie, B, Simpson, JC, Johannes, L, Goud, B, Roberts, LM, Lord, JM, Nilsson, T, Pepperkok, R

Nat. Cell Biol. 1999
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