Reactome: A Curated Pathway Database

Dynein drives COPI-independent retrograde traffic from the Golgi to the ER

Stable Identifier
R-HSA-8849353
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The RAB6 pathway moves select retrograde cargo from the Golgi to the ER in a motor-dependent manner, although the precise details of this translocation remain to be worked out (Girod et al, 1999; White et al, 1999; reviewed in Heffernan and Simpson, 2014). Active RAB18 at the ER membrane may contribute to targeting and fusion of COPI-independent retrograde carriers through interaction with ER-localized tethering factors (Dejgaard et al, 2008; Gerondopoulos et al, 2014; Gillingham et al, 2014)

Literature References
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Orthologous Events