Reactome | p-Y-SFPQ [nucleoplasm]

p-Y-SFPQ [nucleoplasm]

Stable Identifier

R-HSA-8849461

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-Y-PSF

Locations in the PathwayBrowser for interactor UniProt:Q06787 FMR1

Expand all

External Reference Information

External Reference

UniProt:P23246 SFPQ

Gene Names

SFPQ, PSF

Chain

chain:1-707

Reference Genes

BioGPS Gene:6421 SFPQ

COSMIC (genes):SFPQ SFPQ

CTD Gene:6421 SFPQ

dbSNP Gene:6421 SFPQ

ENSEMBL:ENSG00000116560 SFPQ

HGNC:10774 SFPQ

KEGG:hsa:6421 SFPQ

Monarch:6421 SFPQ

NCBI Gene:6421 SFPQ

OMIM:605199 SFPQ

UCSC:P23246 SFPQ

Reference Transcript

Other Identifiers

11720474_a_at

11720475_x_at

16685076

201585_PM_s_at

201585_s_at

201586_PM_s_at

201586_s_at

214016_PM_s_at

214016_s_at

221768_PM_at

221768_at

2406069

2406070

2406071

2406072

2406073

2406074

2406075

2406076

2406077

2406078

2406079

2406080

2406081

2406082

2406083

2406089

2406091

2406093

2406094

2406095

2406096

2406097

2406098

2406100

2406101

2406102

2406103

2406104

2406105

36223_at

36224_g_at

40638_at

41199_s_at

54981_r_at

6421

65790_r_at

74531_s_at

76096_at

7914791

88005_at

A_19_P00329763

A_19_P00805042

A_21_P0014601

A_24_P105283

A_33_P3318292

GE61121

GO:0000122

GO:0000380

GO:0000724

GO:0000785

GO:0000976

GO:0002218

GO:0002376

GO:0003676

GO:0003677

GO:0003682

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006281

GO:0006310

GO:0006325

GO:0006338

GO:0006355

GO:0006397

GO:0008380

GO:0016071

GO:0016363

GO:0016607

GO:0042382

GO:0042752

GO:0042754

GO:0042803

GO:0042826

GO:0043226

GO:0045087

GO:0045892

GO:0045944

GO:0048511

GO:0090575

GO:0098542

GO:1902177

HMNXSV003010292

HMNXSV003044369

HMNXSV003046008

Hs.180610.1.A1_3p_at

Hs.180610.3.A1_3p_a_at

ILMN_1769931

PH_hs_0027942

PH_hs_0039481

TC01005403.hg

X70944_s_at

g4826997_3p_a_at

Participates

as an output of

PTK6 phosphorylates SFPQ (Homo sapiens)

Other forms of this molecule

SFPQ [nucleoplasm]

SFPQ [cytosol]

Inferred To

phospho-Sfpq [nucleoplasm] (Mus musculus)

phospho-Sfpq [nucleoplasm] (Rattus norvegicus)

phospho-nonA [nucleoplasm] (Drosophila melanogaster)

phospho-nono-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-SFPQ [nucleoplasm] (Bos taurus)

phospho-SFPQ [nucleoplasm] (Canis familiaris)

phospho-SFPQ [nucleoplasm] (Gallus gallus)

phospho-SFPQ [nucleoplasm] (Sus scrofa)

phospho-p-Y-SFPQ [nucleoplasm] (Dictyostelium discoideum)

phospho-p-Y-SFPQ [nucleoplasm] (Plasmodium falciparum)

phospho-sfpq [nucleoplasm] (Danio rerio)

phospho-sfpq [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_016857542.1, XP_016857543.1, XP_005271172.1, XP_005271170.1, XP_005271169.1, NP_005057.1

OpenTargets

ENSG00000116560

ENSEMBL

ENSP00000349748, ENST00000357214

HPA

ENSG00000116560-SFPQ

PRO

P23246

Pharos - Targets

P23246

GlyGen

P23246

Orphanet

SFPQ

HMDB Protein

HMDBP01953

PDB

6WMZ, 4WIK, 7UJ1, 6OWJ, 6NCQ, 7UK1, 4WII, 4WIJ, 7SP0, 7PU5, 5WPA, 7LRU, 7LRQ

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15233 NONO			0.881	10
UniProt:P26599 PTBP1	1	PTBP1 [nucleoplasm] (R-HSA-71923)	0.702	4
UniProt:Q8WXF1 PSPC1			0.695	4
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.688	5
UniProt:Q06787 FMR1			0.667	3
UniProt:Q13882 PTK6	5	PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103)	0.632	5
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.615	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	14
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.597	3
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.576	6
UniProt:O60861 GAS7			0.564	2
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.564	2
UniProt:Q68DV7 RNF43	10	RNF43 [plasma membrane] (R-HSA-5323531) ub-RNF43 [plasma membrane] (R-HSA-5323547) RNF43 G659Vfs41 [plasma membrane] (R-HSA-9666643) RNF43 F69C [plasma membrane] (R-HSA-5340578) RNF43 P154L [plasma membrane] (R-HSA-9666646) RNF43 R132 [plasma membrane] (R-HSA-9666650) RNF43 R117Afs41 [plasma membrane] (R-HSA-9666664) RNF43 A169T [plasma membrane] (R-HSA-9666639) RNF43 R330fs89 [plasma membrane] (R-HSA-5340581) RNF43 E174* [plasma membrane] (R-HSA-5340574)	0.556	3
UniProt:P51114 FXR1	2	FXR1(2-784)-BRAF(381-766) fusion [cytosol] (R-HSA-6802326) FXR1(2-784)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802530)	0.547	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:Q9H3L0 MMADHC	8	MMADHC [cytosol] (R-HSA-3149529) MMADHC R250* [cytosol] (R-HSA-3318608) MMADHC T182N [cytosol] (R-HSA-3318599) MMADHC L259P [cytosol] (R-HSA-3318587) MMADHC Y249C [cytosol] (R-HSA-3318584) MMADHC Y140* [cytosol] (R-HSA-3318633) MMADHC R54* [cytosol] (R-HSA-3318620) MMADHC S20* [cytosol] (R-HSA-3318573)	0.527	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:Q9BTC0 DIDO1			0.527	2
UniProt:O75146 HIP1R	3	HIP1R [cytosol] (R-HSA-8868155) HIP1R [Golgi membrane] (R-HSA-434348) HIP1R [cytoplasmic vesicle membrane] (R-HSA-434201)	0.527	2
UniProt:Q9HCD5 NCOA5			0.527	2
UniProt:Q01844 EWS			0.527	2
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.527	2
UniProt:P49366 DHPS	1	DHPS [cytosol] (R-HSA-204630)	0.527	2
UniProt:Q96E39 RMXL1			0.527	2
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.524	2
UniProt:Q9UBW7 ZMYM2	6	ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016)	0.524	4
UniProt:Q8AZK7 EBNA5			0.499	2

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