PTK6 phosphorylates SFPQ

Stable Identifier
R-HSA-8849463
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PTK6 (BRK) binds a large RNA processing nuclear complex that contains SFPQ (PSF) and phosphorylates SFPQ on C-terminal tyrosine residues. PTK6 also phosphorylates at least two additional SFPQ-associated unidentified proteins.

PTK6-mediated phosphorylation disrupts SFPQ binding to RNA and may promote the relocalization of SFPQ to the cytosol and cell cycle arrest (Lukong et al. 2009).

Literature References
PubMed ID Title Journal Year
19439179 BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest Cell. Signal. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-Y342-PTK6 [nucleoplasm]
Physical Entity
Activity
Orthologous Events