PTK6 Regulates Proteins Involved in RNA Processing

Stable Identifier
R-HSA-8849468
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

PTK6 binds and phosphorylates several nuclear RNA-binding proteins, including SAM68 family members (KHDRSB1, KHDRSB2 and KHDRSB3) (Derry et al. 2000, Haegebarth et al. 2004, Lukong et al. 2005) and SFPQ (PSF) (Lukong et al. 2009). The biological role of PTK6 in RNA processing is not known.

Literature References
PubMed ID Title Journal Year
10913193 Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

Derry, JJ, Richard, S, Valderrama Carvajal, H, Ye, X, Vasioukhin, V, Cochrane, AW, Chen, T, Tyner, AL

Mol. Cell. Biol. 2000
15471878 The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2

Haegebarth, A, Heap, D, Bie, W, Derry, JJ, Richard, S, Tyner, AL

J. Biol. Chem. 2004
16179349 Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression

Lukong, KE, Larocque, D, Tyner, AL, Richard, S

J. Biol. Chem. 2005
19439179 BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest

Lukong, KE, Huot, ME, Richard, S

Cell. Signal. 2009
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