Reactome: A Curated Pathway Database

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

Stable Identifier
R-HSA-8849469
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

PTK6 enhances EGFR signaling by inhibiting EGFR down-regulation (Kang et al. 2010, Li et al. 2012, Kang and Lee 2013). PTK6 may also enhance signaling by other receptor tyrosine kinases (RTKs), such as IGF1R (Fan et al. 2013) and ERBB3 (Kamalati et al. 2000).

PTK6 affects AKT1 activation (Zhang et al. 2005, Zheng et al. 2010) and targets negative regulator of RTKs, DOK1, for degradation (Miah et al. 2014).

Literature References
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Orthologous Events