PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

Stable Identifier
R-HSA-8849469
Type
Pathway
Species
Homo sapiens
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PTK6 enhances EGFR signaling by inhibiting EGFR down-regulation (Kang et al. 2010, Li et al. 2012, Kang and Lee 2013). PTK6 may also enhance signaling by other receptor tyrosine kinases (RTKs), such as IGF1R (Fan et al. 2013) and ERBB3 (Kamalati et al. 2000).

PTK6 affects AKT1 activation (Zhang et al. 2005, Zheng et al. 2010) and targets negative regulator of RTKs, DOK1, for degradation (Miah et al. 2014).

Literature References
PubMed ID Title Journal Year
20606012 Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor

Zheng, Y, Peng, M, Wang, Z, Asara, JM, Tyner, AL

Mol. Cell. Biol. 2010
15539407 Regulated association of protein kinase B/Akt with breast tumor kinase

Zhang, P, Ostrander, JH, Faivre, EJ, Olsen, A, Fitzsimmons, D, Lange, CA

J. Biol. Chem. 2005
20554524 PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1

Kang, SA, Lee, ES, Yoon, HY, Randazzo, PA, Lee, ST

J. Biol. Chem. 2010
24523872 BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration

Miah, S, Goel, RK, Dai, C, Kalra, N, Beaton-Brown, E, Bagu, ET, Bonham, K, Lukong, KE

PLoS ONE 2014
23352614 PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation

Kang, SA, Lee, ST

Biochem. Biophys. Res. Commun. 2013
11114724 Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation

Kamalati, T, Jolin, HE, Fry, MJ, Crompton, MR

Oncogene 2000
23814047 Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells

Fan, G, Lin, G, Lucito, R, Tonks, NK

J. Biol. Chem. 2013
22231447 Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR

Li, X, Lu, Y, Liang, K, Hsu, JM, Albarracin, C, Mills, GB, Hung, MC, Fan, Z

Oncogene 2012
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