PTK6 Regulates Cell Cycle

Stable Identifier
R-HSA-8849470
Type
Pathway
Species
Homo sapiens
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PTK6 promotes cell cycle progression by phosphorylating and inactivating CDK inhibitor CDKN1B (p27) (Patel et al. 2015). PTK6 also negatively modulates CDKN1B expression via regulation of the activity of the FOXO3 (FOXO3A) transcription factor (Chan and Nimnual 2010).

Literature References
PubMed ID Title Journal Year
20162673 Deregulation of the cell cycle by breast tumor kinase (Brk)

Chan, E, Nimnual, AS

Int. J. Cancer 2010
25733683 Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4

Patel, P, Asbach, B, Shteyn, E, Gomez, C, Coltoff, A, Bhuyan, S, Tyner, AL, Wagner, R, Blain, SW

Mol. Cell. Biol. 2015
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Orthologous Events
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