PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

Stable Identifier
R-HSA-8849471
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

PTK6 promotes cell motility and migration by regulating the activity of RHO GTPases RAC1 (Chen et al. 2004) and RHOA (Shen et al. 2008). PTK6 inhibits RAS GTPase activating protein RASA1 (Shen et al. 2008) and may be involved in MAPK7 (ERK5) activation (Ostrander et al. 2007, Zheng et al. 2012)

Literature References
PubMed ID Title Journal Year
15572663 Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

Chen, HY, Shen, CH, Tsai, YT, Lin, FC, Huang, YP, Chen, RH

Mol. Cell. Biol. 2004
17483331 Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells

Ostrander, JH, Daniel, AR, Lofgren, K, Kleer, CG, Lange, CA

Cancer Res. 2007
22084245 Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate

Zheng, Y, Asara, JM, Tyner, AL

J. Biol. Chem. 2012
18829532 Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

Shen, CH, Chen, HY, Lin, MS, Li, FY, Chang, CC, Kuo, ML, Settleman, J, Chen, RH

Cancer Res. 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed