PTK6 Down-Regulation

Stable Identifier
R-HSA-8849472
Type
Pathway
Species
Homo sapiens
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The kinase activity of PTK6 is negatively regulated by both PTPN1 phosphatase (Fan et al. 2013), which dephosphorylates tyrosine Y342 of PTK6, and SRMS kinase (Fan et al. 2015), which phosphorylates PTK6 on tyrosine residue Y447.

Literature References
PubMed ID Title Journal Year
23814047 Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells

Fan, G, Lin, G, Lucito, R, Tonks, NK

J. Biol. Chem. 2013
25897081 Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase

Fan, G, Aleem, S, Yang, M, Miller, WT, Tonks, NK

J. Biol. Chem. 2015
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Event Information
Orthologous Events
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