PTK6 Expression

Stable Identifier
R-HSA-8849473
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Levels of PTK6 increase under hypoxic conditions due to direct transcriptional regulation of PTK6 gene by hypoxia inducible transcription factors (HIFs) (Regan Anderson et al. 2013). PTK6 protein levels are also rapidly stabilized in hypoxic conditions in a HIF-independent manner (Pires et al. 2014). It has also been shown that PTK6 is ubiquitinated in normoxic conditions by a so far unknown E3 ligase (Pires et al. 2014).

Literature References
PubMed ID Title Journal Year
25019382 HIF-1?-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion

Pires, IM, Blokland, NJ, Broos, AW, Poujade, FA, Senra, JM, Eccles, SA, Span, PN, Harvey, AJ, Hammond, EM

Cancer Biol. Ther. 2014
23928995 Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression

Regan Anderson, TM, Peacock, DL, Daniel, AR, Hubbard, GK, Lofgren, KA, Girard, BJ, Schörg, A, Hoogewijs, D, Wenger, RH, Seagroves, TN, Lange, CA

Cancer Res. 2013
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