PTK6 Activates STAT3

Stable Identifier
R-HSA-8849474
Type
Pathway
Species
Homo sapiens
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PTK6-mediated phosphorylation activates STAT3 transcription factor via STAP2 adapter protein. STAT3 transcriptional target SOCS3 is a negative regulator of PTK6 and inhibits PTK6-mediated phosphorylation of STAT3, thus creating a negative feedback loop (Liu et al. 2006, Ikeda et al. 2009, Ikeda et al. 2010). PTK6 may also activate STAT5-mediated transcription (Ikeda et al. 2011).

Literature References
PubMed ID Title Journal Year
16568091 Identification of STAT3 as a specific substrate of breast tumor kinase

Liu, L, Gao, Y, Qiu, H, Miller, WT, Poli, V, Reich, NC

Oncogene 2006
19393627 STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

Ikeda, O, Miyasaka, Y, Sekine, Y, Mizushima, A, Muromoto, R, Nanbo, A, Yoshimura, A, Matsuda, T

Biochem. Biophys. Res. Commun. 2009
21205088 Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells

Ikeda, O, Mizushima, A, Sekine, Y, Yamamoto, C, Muromoto, R, Nanbo, A, Oritani, K, Yoshimura, A, Matsuda, T

Cancer Sci. 2011
20929863 Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells

Ikeda, O, Sekine, Y, Mizushima, A, Nakasuji, M, Miyasaka, Y, Yamamoto, C, Muromoto, R, Nanbo, A, Oritani, K, Yoshimura, A, Matsuda, T

J. Biol. Chem. 2010
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