Dissociation of the SPINK5:KLK5 complex at low pH

Stable Identifier
R-HSA-8849638
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

At low pH, the complex of the D8D9 fragment of SPINK5 (Serine protease inhibitor Kazal-type 5, also known as LEKTI, Lympho-epithelial Kazal-type-related inhibitor), consisting of residues 490 - 624 of the full-length protein, and KLK5 (Kallikrein-5) dissociates, releasing active KLK5 protease. In normal skin, this event occurs extracellularly in upper layers of the skin (Deraison et al. 2007).

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