KLK5 cleaves and activates CELA2

Stable Identifier
R-HSA-8849857
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the low-pH environment of the upper layers of the stratum corneum, KLK5 (Kallikrein 5) dissociates from its complex with SPINK5 (Serine protease inhibitor kazal-type 5) (Deraison et al. 2007) and is free to cleave proCELA2 (Elastase 2), activating it (Bonnart et al. 2010).

Literature References
PubMed ID Title Journal Year
17596512 LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction

Deraison, C, Bonnart, C, Lopez, F, Besson, C, Robinson, R, Jayakumar, A, Wagberg, F, Brattsand, M, Hachem, JP, Leonardsson, G, Hovnanian, A

Mol. Biol. Cell 2007
20179351 Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

Bonnart, C, Deraison, C, Lacroix, M, Uchida, Y, Besson, C, Robin, A, Briot, A, Gonthier, M, Lamant, L, Dubus, P, Monsarrat, B, Hovnanian, A

J. Clin. Invest. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of KLK5 [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created